Dear Editor,As mass vaccination has been accomplished worldwide and a growing number of individuals have already been infected by SARS-CoV-2,understanding the incidence of subsequent re-infection is urgently required ...Dear Editor,As mass vaccination has been accomplished worldwide and a growing number of individuals have already been infected by SARS-CoV-2,understanding the incidence of subsequent re-infection is urgently required for comprehending the transmission dynamics of COVID-19(Bobrovitz et al.,2023).Additionally,current SARS-CoV-2 variants cause widespread escape from the neutralizing antibody(nAb)elicited by current vaccines.Meanwhile,durable neutralization and memory B cell responses can be predicted by rapid CD4t T cell responses,particularly strong circulating T follicular helper(cTfh)cell responses,in individuals infected with SARS-CoV-2(Gong et al.,2020;Boppana et al.,2021;Narowski et al.,2022).Although nAb titers are known as predictors of protection against SARS-CoV-2 variants(Khoury et al.,2021),identifying more potential factors that could predict the risk of re-infection following primary infection and vaccination has become quite important in shaping prevention strategies(Chemaitelly et al.,2023).展开更多
基金supported by the National Key R&D Program of Department of Science and Technology of China(2022YFC0870700)the Important Key Program of Natural Science Foundation of China(NSFC)(92169201)+3 种基金the Exchange Program of NSFC(82150710553)the Emergency Key Program of Guangzhou National Laboratory(EKPG21-24)the Key R&D Program of Department of Science and Technology of Guangdong(2022B1111020004)to H.Z.Natural Science Foundation of China(92169108 and 32000613)Guangdong Natural Science Funds for Distinguished Young Scholar(2023B1515020005)to Y.Z.
文摘Dear Editor,As mass vaccination has been accomplished worldwide and a growing number of individuals have already been infected by SARS-CoV-2,understanding the incidence of subsequent re-infection is urgently required for comprehending the transmission dynamics of COVID-19(Bobrovitz et al.,2023).Additionally,current SARS-CoV-2 variants cause widespread escape from the neutralizing antibody(nAb)elicited by current vaccines.Meanwhile,durable neutralization and memory B cell responses can be predicted by rapid CD4t T cell responses,particularly strong circulating T follicular helper(cTfh)cell responses,in individuals infected with SARS-CoV-2(Gong et al.,2020;Boppana et al.,2021;Narowski et al.,2022).Although nAb titers are known as predictors of protection against SARS-CoV-2 variants(Khoury et al.,2021),identifying more potential factors that could predict the risk of re-infection following primary infection and vaccination has become quite important in shaping prevention strategies(Chemaitelly et al.,2023).
