Spinal cord injury(SCI),which causes irreversible damage in both sensory and motor function,is considered an insurmountable challenge in the field of medicine.The previous researchers have developed many kinds of biom...Spinal cord injury(SCI),which causes irreversible damage in both sensory and motor function,is considered an insurmountable challenge in the field of medicine.The previous researchers have developed many kinds of biomaterials for SCI,and spinal cord conduits(SCCs)are an important classification for bridging spinal cord tissues while performing their corresponding functions.In this review,we first describe the original sources of the different polymers that determine the properties of the different SCCs.Afterwards,we focus on the different types of crosslinking methods used for preparing SCCs.Then,various practical applications and therapeutic effects of SCCs are summarized and discussed.Finally,we conclude the existing limitations of current SCCs.We hope that this paper will serve as a further inspiration for the development of SCCs in future.展开更多
基金supported by National Natural Science Foundation of China (8197202982102637)+5 种基金China Post-doctoral Science Foundation (2021M701675)Jiangsu Province 333 Talent Grant (2016-III-0114)Jiangsu commission of health (K2019009)Guangdong Basic and Applied Basic Research Foundation (2019A1515111155)the Shenzhen Fundamental Research Program (JCYJ20190808120405672)Public Health and Welfare Research Project of Futian District of Shenzhen (FTWS2022013).
文摘Spinal cord injury(SCI),which causes irreversible damage in both sensory and motor function,is considered an insurmountable challenge in the field of medicine.The previous researchers have developed many kinds of biomaterials for SCI,and spinal cord conduits(SCCs)are an important classification for bridging spinal cord tissues while performing their corresponding functions.In this review,we first describe the original sources of the different polymers that determine the properties of the different SCCs.Afterwards,we focus on the different types of crosslinking methods used for preparing SCCs.Then,various practical applications and therapeutic effects of SCCs are summarized and discussed.Finally,we conclude the existing limitations of current SCCs.We hope that this paper will serve as a further inspiration for the development of SCCs in future.
