Microwave-induced thermoacoustic imaging(MI-TAI)remains one of the focus of attention among biomedical imaging modalities over the last decade.However,the transmission and dis-tribution of microwave inside bio-tissues...Microwave-induced thermoacoustic imaging(MI-TAI)remains one of the focus of attention among biomedical imaging modalities over the last decade.However,the transmission and dis-tribution of microwave inside bio-tissues are complicated,thus result in severe artifacts.In this study,to reveal the underlying mechanisms of artifacts,we deeply investigate the distribution of specific absorption rate(SAR)inside tissue-mimicking phantoms with varied morphological features using both mathematical simulations and corresponding experiments.Our simulated results,which are confirmed by the associated experimental results,show that the SAR distri-bution highly depends on the geometries of the imaging targets and the polarizing features of the microwave.In addition,we propose the potential mechanisms including Mie-scattering,Fabry-Perot-feature,small curvature effect to interpret the diffraction effect in different scenarios,which may provide basic guidance to predict and distinguish the artifacts for TAI in both fundamental and clinical studies.展开更多
During the past decade,semiconducting polymer dots(Pdots)have been prevailing in the family of fluorescent probes due to its high photon budget,excellent photo stability,and good biocompatibility.In this study,holo-Tr...During the past decade,semiconducting polymer dots(Pdots)have been prevailing in the family of fluorescent probes due to its high photon budget,excellent photo stability,and good biocompatibility.In this study,holo-Transferrin human(Tf)was utilized to covalently couple with Pdots for a highly efficient endocytosis process through transferrin receptors(TfRs)mediated internalization.As a result,the endocytosis efficiency of Tf-conjugated Pdots in HeLa cells dramatically increased as compared to that of unconjugated Pdots in the same condition.This acute increment demonstrates that holo-Transferrin molecules are of great capability for intracellular delivery of Pdots to TfRs overexpressed cells.The transportation route of Tf-conjugated Pdots is quite different from the uptake mechanism of unconjugated Pdots via nonspecific endocytic trafficking pathway.Considering the overexpression of TfRs in various cancer cells,Tf-conjugated Pdots hold potential to function as a nanocarrier for efficient drug delivery in cancer diagnostics and therapy.展开更多
1.Main Text Launched into orbit on July 23,2020,China’s first Mars mission Tianwen-1 has implemented the key missions of“near-Mars capture and brake,”“entry,descent,and landing(EDL),”and“rover leaving the landin...1.Main Text Launched into orbit on July 23,2020,China’s first Mars mission Tianwen-1 has implemented the key missions of“near-Mars capture and brake,”“entry,descent,and landing(EDL),”and“rover leaving the landing platform”successively in nearly one year.The three major tasks of“orbiting around Mars,”“Mars surface landing,”and“exploration and detection”have also been accomplished.At present,the Zhurong Mars rover is performing exploration and detection tasks as planned.For Tianwen-1,China’s first probe landing on an extraterrestrial planet to carry out such elaborate tasks,EDL is the risk point of the Mars mission that is mostly difficult to accomplish.展开更多
基金This study was supported by the National Natural Science Foundation of China(Nos.62022037,61775028,81571722,61528401 and 61921002)Guangdong province(2019ZT08Y191)+1 种基金Shenzhen Science and Technology Program(KQTD20190929172743294)Startup grant from Southern University of Science and Technology.
文摘Microwave-induced thermoacoustic imaging(MI-TAI)remains one of the focus of attention among biomedical imaging modalities over the last decade.However,the transmission and dis-tribution of microwave inside bio-tissues are complicated,thus result in severe artifacts.In this study,to reveal the underlying mechanisms of artifacts,we deeply investigate the distribution of specific absorption rate(SAR)inside tissue-mimicking phantoms with varied morphological features using both mathematical simulations and corresponding experiments.Our simulated results,which are confirmed by the associated experimental results,show that the SAR distri-bution highly depends on the geometries of the imaging targets and the polarizing features of the microwave.In addition,we propose the potential mechanisms including Mie-scattering,Fabry-Perot-feature,small curvature effect to interpret the diffraction effect in different scenarios,which may provide basic guidance to predict and distinguish the artifacts for TAI in both fundamental and clinical studies.
基金the grants from the National Natural Science Foundation of China(Grant Nos.6133500181771930)Shenzhen Science and Technology Innovation Commission(Grant No.JCYJ20170307110157501).
文摘During the past decade,semiconducting polymer dots(Pdots)have been prevailing in the family of fluorescent probes due to its high photon budget,excellent photo stability,and good biocompatibility.In this study,holo-Transferrin human(Tf)was utilized to covalently couple with Pdots for a highly efficient endocytosis process through transferrin receptors(TfRs)mediated internalization.As a result,the endocytosis efficiency of Tf-conjugated Pdots in HeLa cells dramatically increased as compared to that of unconjugated Pdots in the same condition.This acute increment demonstrates that holo-Transferrin molecules are of great capability for intracellular delivery of Pdots to TfRs overexpressed cells.The transportation route of Tf-conjugated Pdots is quite different from the uptake mechanism of unconjugated Pdots via nonspecific endocytic trafficking pathway.Considering the overexpression of TfRs in various cancer cells,Tf-conjugated Pdots hold potential to function as a nanocarrier for efficient drug delivery in cancer diagnostics and therapy.
文摘1.Main Text Launched into orbit on July 23,2020,China’s first Mars mission Tianwen-1 has implemented the key missions of“near-Mars capture and brake,”“entry,descent,and landing(EDL),”and“rover leaving the landing platform”successively in nearly one year.The three major tasks of“orbiting around Mars,”“Mars surface landing,”and“exploration and detection”have also been accomplished.At present,the Zhurong Mars rover is performing exploration and detection tasks as planned.For Tianwen-1,China’s first probe landing on an extraterrestrial planet to carry out such elaborate tasks,EDL is the risk point of the Mars mission that is mostly difficult to accomplish.