Main quadrupole magnets are critical for the Circular Electron and Positron Collider(CEPC)and are specifically designed as dual aperture quadrupole(DAQ)magnets.However,the field crosstalk between the two apertures pre...Main quadrupole magnets are critical for the Circular Electron and Positron Collider(CEPC)and are specifically designed as dual aperture quadrupole(DAQ)magnets.However,the field crosstalk between the two apertures presents challenges.As the CEPC will work at four beam energies of Z,W,Higgs and ttbar mode,the DAQ magnets will operate at four field gradients spanning from 3.18 to 12.63 T/m.The first short quadrupole magnet prototype with the bore diameter of 76 mm and magnetic length of 1.0 m revealed the problems of large magnetic field harmonics and a magnetic center shift within the beam energy range.Accordingly,a compensation method was proposed in this work to solve the field crosstalk effect.By adjusting the gap height at the middle of the two apertures,the field harmonics and magnetic center shift are significantly reduced.After optimization,the short prototype was modified using a new scheme.The field simulations are validated from the magnetic measurement results.Further,the multipole field meets the requirements of the four beam energies.The detailed magnetic field optimization,field harmonics adjustment,and measurement results are presented herein.展开更多
While typesetting the article,in the Figs.13 and 17 there were several errors introduced.The correct Figs.13 and 17 are copied below:The original article has been corrected.
Objective:Alzheimer’s disease(AD)is along with cognitive decline due to amyloid-β(Aβ)plaques,tau hyperphospho rylation,and neuron loss.Shenqi Xingnao Granules(SQXN),a traditional Chinese medicine,significantly amel...Objective:Alzheimer’s disease(AD)is along with cognitive decline due to amyloid-β(Aβ)plaques,tau hyperphospho rylation,and neuron loss.Shenqi Xingnao Granules(SQXN),a traditional Chinese medicine,significantly ameliorated the cognitive function and daily living abilities of patients with AD.However,till date,no study has investigated the mechanism of action of SQXN on AD.The present study aimed to verify the effects of SQXN treatment on cognitive impairments and AD-like pathologies in APP/PS1 mice.Methods:Four-month-old APP/PS1 transgenic(Tg)mice were randomly divided into a model group and SQXN-treated(3.5,7,14 g/kg per day)groups.Learning-memory abilities were determined by Morris water maze and object recognition test.All mice were sacrificed and the brain samples were collected after 75 d.The soluble Aβcontents were detected by Elisa kit;The levels of expression of NeuN,APP,phosphorylated tau and related protein were measured by Western blotting;The inflammation factors were detected by the proinflammatory panel kit.Results:Four-month-old APP/PS1 mice were administered SQXN by oral gavage for 2.5 months.Using the Morris water maze tests and Novel object recognition,we found that SQXN restored behavioral deficits in the experimental group of Tg mice when compared with the controls.SQXN also inhibited neuronal loss(NeuN marker).SQXN treatment decreased soluble Aβ42 through inhibiting the expression of sAPPβand BACE-1 without regulating full-length amyloid precursor protein(FL APP).Insulin degrading enzyme(IDE),the Aβdegrading enzyme,were increased by SQXN.In addition,SQXN reduced hyperphosphorylated tau protein levels and prevented excessive activation of p-GSK-3βin the brain of APP/PS1 mice.Compared with APP/PS1 transgenic negative mice,IFN-γ,IL-1β,IL-2,IL-4,IL-5,IL-6,IL-12 p70,KC/GRO and TNF-αwere not obviously changed in the brain of 6.5-month-old APP/PS1 transgenic(Tg)mice.However,SQXN could inhibited the expression of IL-2.Conclusion:These results demonstrate that SQXN ameliorates the cognitive impairments in APP/PS1 mice.The possible mechanisms involve its inhibition of neuronal loss,soluble Aβdeposition,tau hyperphosphorylation and inflammation.展开更多
文摘Main quadrupole magnets are critical for the Circular Electron and Positron Collider(CEPC)and are specifically designed as dual aperture quadrupole(DAQ)magnets.However,the field crosstalk between the two apertures presents challenges.As the CEPC will work at four beam energies of Z,W,Higgs and ttbar mode,the DAQ magnets will operate at four field gradients spanning from 3.18 to 12.63 T/m.The first short quadrupole magnet prototype with the bore diameter of 76 mm and magnetic length of 1.0 m revealed the problems of large magnetic field harmonics and a magnetic center shift within the beam energy range.Accordingly,a compensation method was proposed in this work to solve the field crosstalk effect.By adjusting the gap height at the middle of the two apertures,the field harmonics and magnetic center shift are significantly reduced.After optimization,the short prototype was modified using a new scheme.The field simulations are validated from the magnetic measurement results.Further,the multipole field meets the requirements of the four beam energies.The detailed magnetic field optimization,field harmonics adjustment,and measurement results are presented herein.
文摘While typesetting the article,in the Figs.13 and 17 there were several errors introduced.The correct Figs.13 and 17 are copied below:The original article has been corrected.
基金supported by the State Key Program of National Natural Science of China(grant number 81430100)Beijing Hundred,Thousand and Ten Thousand Talent Project(grant number 2018A04)+1 种基金National Science Fund for Distinguished Young Scholars(grant number 81625025)Beijing Municipal Science&Technology Commission(grant number Z161100000216135)。
文摘Objective:Alzheimer’s disease(AD)is along with cognitive decline due to amyloid-β(Aβ)plaques,tau hyperphospho rylation,and neuron loss.Shenqi Xingnao Granules(SQXN),a traditional Chinese medicine,significantly ameliorated the cognitive function and daily living abilities of patients with AD.However,till date,no study has investigated the mechanism of action of SQXN on AD.The present study aimed to verify the effects of SQXN treatment on cognitive impairments and AD-like pathologies in APP/PS1 mice.Methods:Four-month-old APP/PS1 transgenic(Tg)mice were randomly divided into a model group and SQXN-treated(3.5,7,14 g/kg per day)groups.Learning-memory abilities were determined by Morris water maze and object recognition test.All mice were sacrificed and the brain samples were collected after 75 d.The soluble Aβcontents were detected by Elisa kit;The levels of expression of NeuN,APP,phosphorylated tau and related protein were measured by Western blotting;The inflammation factors were detected by the proinflammatory panel kit.Results:Four-month-old APP/PS1 mice were administered SQXN by oral gavage for 2.5 months.Using the Morris water maze tests and Novel object recognition,we found that SQXN restored behavioral deficits in the experimental group of Tg mice when compared with the controls.SQXN also inhibited neuronal loss(NeuN marker).SQXN treatment decreased soluble Aβ42 through inhibiting the expression of sAPPβand BACE-1 without regulating full-length amyloid precursor protein(FL APP).Insulin degrading enzyme(IDE),the Aβdegrading enzyme,were increased by SQXN.In addition,SQXN reduced hyperphosphorylated tau protein levels and prevented excessive activation of p-GSK-3βin the brain of APP/PS1 mice.Compared with APP/PS1 transgenic negative mice,IFN-γ,IL-1β,IL-2,IL-4,IL-5,IL-6,IL-12 p70,KC/GRO and TNF-αwere not obviously changed in the brain of 6.5-month-old APP/PS1 transgenic(Tg)mice.However,SQXN could inhibited the expression of IL-2.Conclusion:These results demonstrate that SQXN ameliorates the cognitive impairments in APP/PS1 mice.The possible mechanisms involve its inhibition of neuronal loss,soluble Aβdeposition,tau hyperphosphorylation and inflammation.
