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本维莫德治疗掌跖脓疱病:一项天津地区多中心临床研究
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作者 张帅 王光平 +9 位作者 王红梅 李燕 曾三武 闫慧敏 齐放 宋静娜 王斯尧 张池金 张秉新 纪黎明 《临床皮肤科杂志》 CAS CSCD 北大核心 2024年第4期204-207,共4页
目的:评价本维莫德在临床研究中治疗掌跖脓疱病的安全性和有效性。方法:选择2021年3月一10月于天津地区多中心应用本维莫德治疗的掌跖脓疱病患者,进行为期8周的治疗及停药后4周的随访,评价患者用药前、后掌跖脓疱病面积和严重程度指数(P... 目的:评价本维莫德在临床研究中治疗掌跖脓疱病的安全性和有效性。方法:选择2021年3月一10月于天津地区多中心应用本维莫德治疗的掌跖脓疱病患者,进行为期8周的治疗及停药后4周的随访,评价患者用药前、后掌跖脓疱病面积和严重程度指数(PPPASI)评分和皮肤病生活质量指数(DLQI)评分,并观察不良反应。结果:治疗8周后,所有患者PPPASI评分与DLQI评分较基线均显著降低,差异均有统计学意义(P<0.05)。治疗8周后,所有患者中痊愈4例、显效4例、有效8例、无效5例,有效率为38.1%。疗程中患者不良反应少且轻微,1例患者出现皮肤肥厚、干燥、脱屑。随访4周,痊愈、显效及有效患者皮损均未复发。结论:本维莫德有望成为治疗掌跖脓疱病的一种有效选择,且不良反应轻微,值得临床进一步研究及应用。 展开更多
关键词 本维莫德 掌跖脓疱病 银屑病 有效性 安全性
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Recent Progresses on Optimal Design of Heat Integrated Water Allocation Network
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作者 zhang chijin Ren Congjing +3 位作者 Liao Zuwei Sun Jingyuan Wang Jingdai Yang Yongrong 《China Petroleum Processing & Petrochemical Technology》 SCIE CAS 2021年第3期69-75,共7页
Energy integration and mass integration are important approaches to achieve energy saving and emission reduction in the process industry.Generally,the methods can be classified into two groups,viz.:conceptual design m... Energy integration and mass integration are important approaches to achieve energy saving and emission reduction in the process industry.Generally,the methods can be classified into two groups,viz.:conceptual design methods and mathematical programming methods.The former includes mainly graphical methods based on pinch technology that is operated easily.A feasible solution can be quickly obtained.Conceptual design methods are sequential in nature including two steps,namely:targeting and designing.The latter is based on superstructure optimization,and corresponding algorithm is adopted to solve the model.The trade-offs and connections among the entire network can be established and explored.Multiple factors can be considered and optimized simultaneously by mathematical programming methods.This paper describes the synthesis of heat integrated water allocation networks(HIWAN)based on both conceptual design methods and mathematical programming methods systematically.In addition,the characteristics and shortcomings of the existing research methods are summarized,and the future research direction is prospected. 展开更多
关键词 heat integrated water allocation network conceptual design mathematical programming
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