目的:探讨趋化素样因子超家族6(chemokine-like factor-like MARVEL transmembrane domain-containing family member 6,CMTM6)在乳腺癌组织中的表达及其与患者临床病理特征和预后的相关性。方法:选用购自芯超公司的136例乳腺癌组织芯片...目的:探讨趋化素样因子超家族6(chemokine-like factor-like MARVEL transmembrane domain-containing family member 6,CMTM6)在乳腺癌组织中的表达及其与患者临床病理特征和预后的相关性。方法:选用购自芯超公司的136例乳腺癌组织芯片,其中包括42例配对的癌及癌旁组织,用免疫组织化学染色法检测乳腺癌及癌旁组织中CMTM6的表达水平。用配对χ~2检验比较CMTM6在乳腺癌及癌旁组织中的表达差异,用χ~2检验分析乳腺癌组织中CMTM6表达水平与患者临床病理特征的关系,用Kaplan-Meier及Log rank分析CMTM6表达水平与患者生存期的关系,拟合Cox模型评价不同指标对患者预后的影响程度。结果:CMTM6在乳腺癌组织中的表达水平显著高于癌旁组织(P<0.01)。CMTM6的表达与乳腺癌病理分型和HER2阳性相关(P<0.05)。CMTM6高表达组患者的生存期较CMTM6低表达组显著缩短(P<0.05)。乳腺癌病理分型(HR=10.374,95%CI:3.529~30.497,P<0.01)、TNM分期(HR=4.599,95%CI:1.784~11.856,P<0.01)、三阴性乳腺癌(HR=3.370,95%CI:1.055~10.761,P<0.05)和CMTM6高表达(HR=0.195,95%CI:0.073~0.518,P<0.01)均可作为评判乳腺癌患者预后的独立危险因素。结论:CMTM6在乳腺癌组织中高表达,其可作为乳腺癌患者预后评估的危险因素。展开更多
弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)是一组临床异质性恶性肿瘤。DLBCL患者的一线治疗是R-CHOP方案,但30%40%的患者治疗后出现复发难治。因此,寻找新的药物靶点和有效的治疗药物是提高DLBCL患者生存率的迫切需要...弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)是一组临床异质性恶性肿瘤。DLBCL患者的一线治疗是R-CHOP方案,但30%40%的患者治疗后出现复发难治。因此,寻找新的药物靶点和有效的治疗药物是提高DLBCL患者生存率的迫切需要。高通量测序又名二代测序(next-generation sequencing,NGS),其在肿瘤基因检测中发展迅速,已经成为肿瘤精准靶向治疗和免疫治疗的核心发展及应用技术。展开更多
A series of biaxial two-level variable amplitude loading tests are conducted on smooth tubular specimens of LY12CZ alumin- ium alloy. The loading paths of 90° out-of-phase, 45° out-of-phase and 45° in-p...A series of biaxial two-level variable amplitude loading tests are conducted on smooth tubular specimens of LY12CZ alumin- ium alloy. The loading paths of 90° out-of-phase, 45° out-of-phase and 45° in-phase are utilized. The fatigue damage cumulative rules under two-level step loading of three loading paths are analyzed. By introducing a parameter a which is a function of the phase lag angle between the axial and the torsional loading, a new multiaxial nonlinear fatigue damage cumulative model is proposed. The proposed model is evaluated by the experimental aluminium alloy, and multi-level loading of 45 steel. Fatigue lives data for two-level loading, multi-level loading of LY12CZ predicted are within a factor of 2 scatter band.展开更多
Carbonyl-containing volatile organic compounds （cVOCs） are important precursors of atmospheric photochemical reactions in the formation of ozone, smog and other air pollutants. China＇s megacities are economically d...Carbonyl-containing volatile organic compounds （cVOCs） are important precursors of atmospheric photochemical reactions in the formation of ozone, smog and other air pollutants. China＇s megacities are economically developed and densely populated metropolitan areas, usually with a population over ten million; they drive the rapid growth of surrounding urban clusters. So far, 21 cVOCs have been detected in the atmosphere of these megacities. The average annual total concentration of cVOCs is 55.6 μg/m^3, an alarmingly high level. Vehicle emissions, industrial discharges, excessive use of organic solvents and other factors have led to a situation where hazardous formaldehyde, acetaldehyde and acetone account for 62.4 percent of the total atmospheric concentration of cVOC in Chinese cities. In a quantitative evaluation using daily exposure levels, cancer risk and hazardquotient, we found that the excessive levels of atmospheric cVOCs in Beijing, Shanghai and Guangzhou pose serious health risks to their inhabitants. Air pollution persists, despite the brief improvements in air quality brought about by the air quality campaign undertaken during major intemational events like the 2008 Olympic Games, the 2010 Asian Games, and the 2010 World Expo. The health risks caused by atmospheric cVOCs in Chinese cities require close attention.展开更多
The articles are selected from the conference papers of the First Sino-US High Level Scholarly Forum on Tradition, which was jointly hosted by the Social Sciences in China Press and Wesleyan University in October 2011...The articles are selected from the conference papers of the First Sino-US High Level Scholarly Forum on Tradition, which was jointly hosted by the Social Sciences in China Press and Wesleyan University in October 2011, in Beijing. This issue is intended to offer an overview of the loci and interests of the forum. It seems rather undesirable to start a direct discussion about tradition in contemporary China, and even a bit annoying to present the topic in an international academic domain; a transnational and cross-cultural dialogue between Chinese and American scholars would be more readily accepted. For the present, it might be extremely difficult to find a proper perspective on tradition in China. Yet some thinking on how to reasonably handle tradition and reflect upon history is steadily and quietly underway.展开更多
Though it is not new, the topic of the modem transformation of classical Chinese literary theory still holds profound significance for China＇s current efforts in carrying forward the essence of classical literary the...Though it is not new, the topic of the modem transformation of classical Chinese literary theory still holds profound significance for China＇s current efforts in carrying forward the essence of classical literary theory and constructing a new literary theory that conforms to the spirit of our times. Today, Chinese scholars have to handle two traditions： one is the classical literary scholarship up to the 19th century, distant in time and space from today; the other is the modern tradition that started in the early 20th century. These two traditions involve not only rupture and heterogeneous change but also continuity and partial homogeneous preservation. Taking our stand on the modem and contemporary tradition, we should consciously pursue research on classical literary theory, using modem consciousness to scrutinize, reorder, discover, select, interpret, activate and absorb its finer elements, those that are still vital, so as to creatively promote its modem transformation and further integrate it as an organic component of the construction of modem Chinese literary theory. Over the past two or three decades, Chinese scholars have been advancing this great project in a systematic and solid way, achieving gratifying progress. We must strengthen our efforts and make further progress with this great undertaking.展开更多
文摘目的:探讨趋化素样因子超家族6(chemokine-like factor-like MARVEL transmembrane domain-containing family member 6,CMTM6)在乳腺癌组织中的表达及其与患者临床病理特征和预后的相关性。方法:选用购自芯超公司的136例乳腺癌组织芯片,其中包括42例配对的癌及癌旁组织,用免疫组织化学染色法检测乳腺癌及癌旁组织中CMTM6的表达水平。用配对χ~2检验比较CMTM6在乳腺癌及癌旁组织中的表达差异,用χ~2检验分析乳腺癌组织中CMTM6表达水平与患者临床病理特征的关系,用Kaplan-Meier及Log rank分析CMTM6表达水平与患者生存期的关系,拟合Cox模型评价不同指标对患者预后的影响程度。结果:CMTM6在乳腺癌组织中的表达水平显著高于癌旁组织(P<0.01)。CMTM6的表达与乳腺癌病理分型和HER2阳性相关(P<0.05)。CMTM6高表达组患者的生存期较CMTM6低表达组显著缩短(P<0.05)。乳腺癌病理分型(HR=10.374,95%CI:3.529~30.497,P<0.01)、TNM分期(HR=4.599,95%CI:1.784~11.856,P<0.01)、三阴性乳腺癌(HR=3.370,95%CI:1.055~10.761,P<0.05)和CMTM6高表达(HR=0.195,95%CI:0.073~0.518,P<0.01)均可作为评判乳腺癌患者预后的独立危险因素。结论:CMTM6在乳腺癌组织中高表达,其可作为乳腺癌患者预后评估的危险因素。
文摘弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)是一组临床异质性恶性肿瘤。DLBCL患者的一线治疗是R-CHOP方案,但30%40%的患者治疗后出现复发难治。因此,寻找新的药物靶点和有效的治疗药物是提高DLBCL患者生存率的迫切需要。高通量测序又名二代测序(next-generation sequencing,NGS),其在肿瘤基因检测中发展迅速,已经成为肿瘤精准靶向治疗和免疫治疗的核心发展及应用技术。
基金supported by the National Natural Science Foundation of China(Grant No.10702027)Aviation Science Funds of China(Grant No.2011ZA52016)Program for Changjiang Scholars and Innovative Research Team in University(Grant No.Irt0906)
文摘A series of biaxial two-level variable amplitude loading tests are conducted on smooth tubular specimens of LY12CZ alumin- ium alloy. The loading paths of 90° out-of-phase, 45° out-of-phase and 45° in-phase are utilized. The fatigue damage cumulative rules under two-level step loading of three loading paths are analyzed. By introducing a parameter a which is a function of the phase lag angle between the axial and the torsional loading, a new multiaxial nonlinear fatigue damage cumulative model is proposed. The proposed model is evaluated by the experimental aluminium alloy, and multi-level loading of 45 steel. Fatigue lives data for two-level loading, multi-level loading of LY12CZ predicted are within a factor of 2 scatter band.
基金supported by the National Natural Science Foundation of China Fund(No.40975077)the National Natural Science Foundation of China and Guangdong Province Joint Fund(No.U1201232)
文摘Carbonyl-containing volatile organic compounds （cVOCs） are important precursors of atmospheric photochemical reactions in the formation of ozone, smog and other air pollutants. China＇s megacities are economically developed and densely populated metropolitan areas, usually with a population over ten million; they drive the rapid growth of surrounding urban clusters. So far, 21 cVOCs have been detected in the atmosphere of these megacities. The average annual total concentration of cVOCs is 55.6 μg/m^3, an alarmingly high level. Vehicle emissions, industrial discharges, excessive use of organic solvents and other factors have led to a situation where hazardous formaldehyde, acetaldehyde and acetone account for 62.4 percent of the total atmospheric concentration of cVOC in Chinese cities. In a quantitative evaluation using daily exposure levels, cancer risk and hazardquotient, we found that the excessive levels of atmospheric cVOCs in Beijing, Shanghai and Guangzhou pose serious health risks to their inhabitants. Air pollution persists, despite the brief improvements in air quality brought about by the air quality campaign undertaken during major intemational events like the 2008 Olympic Games, the 2010 Asian Games, and the 2010 World Expo. The health risks caused by atmospheric cVOCs in Chinese cities require close attention.
文摘The articles are selected from the conference papers of the First Sino-US High Level Scholarly Forum on Tradition, which was jointly hosted by the Social Sciences in China Press and Wesleyan University in October 2011, in Beijing. This issue is intended to offer an overview of the loci and interests of the forum. It seems rather undesirable to start a direct discussion about tradition in contemporary China, and even a bit annoying to present the topic in an international academic domain; a transnational and cross-cultural dialogue between Chinese and American scholars would be more readily accepted. For the present, it might be extremely difficult to find a proper perspective on tradition in China. Yet some thinking on how to reasonably handle tradition and reflect upon history is steadily and quietly underway.
文摘Though it is not new, the topic of the modem transformation of classical Chinese literary theory still holds profound significance for China＇s current efforts in carrying forward the essence of classical literary theory and constructing a new literary theory that conforms to the spirit of our times. Today, Chinese scholars have to handle two traditions： one is the classical literary scholarship up to the 19th century, distant in time and space from today; the other is the modern tradition that started in the early 20th century. These two traditions involve not only rupture and heterogeneous change but also continuity and partial homogeneous preservation. Taking our stand on the modem and contemporary tradition, we should consciously pursue research on classical literary theory, using modem consciousness to scrutinize, reorder, discover, select, interpret, activate and absorb its finer elements, those that are still vital, so as to creatively promote its modem transformation and further integrate it as an organic component of the construction of modem Chinese literary theory. Over the past two or three decades, Chinese scholars have been advancing this great project in a systematic and solid way, achieving gratifying progress. We must strengthen our efforts and make further progress with this great undertaking.
