【据Journal of Hepatology 2020年8月报道】题:TET1促进IDH1野生型胆管癌的恶性进展(作者Bai X等)胆管癌(CCA)是一种高致死性疾病,缺乏有效的治疗方法。全基因组测序结果表明,约有20%的CCA患者存在IDH1突变,这些突变被认为是以依赖于2...【据Journal of Hepatology 2020年8月报道】题:TET1促进IDH1野生型胆管癌的恶性进展(作者Bai X等)胆管癌(CCA)是一种高致死性疾病,缺乏有效的治疗方法。全基因组测序结果表明,约有20%的CCA患者存在IDH1突变,这些突变被认为是以依赖于2-氧戊二酸(OG)的双加氧酶为靶点促进CCA癌变。展开更多
INTRODUCTIONChronic gastritis(CG)and peptic ulcer(PU)arefrequently-occurring diseases.It is now well recognizedthat Helicobacter pylori(Hp)is a major factor that leadsto CG and PU.In order to study the relationshipamo...INTRODUCTIONChronic gastritis(CG)and peptic ulcer(PU)arefrequently-occurring diseases.It is now well recognizedthat Helicobacter pylori(Hp)is a major factor that leadsto CG and PU.In order to study the relationshipamong T lymphocyte subsets,NO,Hexosamine and展开更多
Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following ...Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM.展开更多
【据Journal of Hepatology 2021年12月报道】题:调节性T淋巴细胞和中性粒细胞胞外陷阱相互作用促进非酒精性脂肪性肝炎向肝细胞癌的转化(作者Wang H等)非酒精性脂肪性肝病(NAFLD)困扰着很大一部分西方人口,并在发展中国家迅速蔓延。非...【据Journal of Hepatology 2021年12月报道】题:调节性T淋巴细胞和中性粒细胞胞外陷阱相互作用促进非酒精性脂肪性肝炎向肝细胞癌的转化(作者Wang H等)非酒精性脂肪性肝病(NAFLD)困扰着很大一部分西方人口,并在发展中国家迅速蔓延。非酒精性脂肪性肝炎(NASH)是NAFLD的一种侵袭性形式。在美国,10%~20%的NASH患者会发展成为终末期肝病,如肝硬化,并在5~10年内进一步发展为肝细胞癌(HCC)。迄今为止,尚无能够阻止或者逆转NASH及其并发症的有效干预手段。展开更多
文摘【据Journal of Hepatology 2020年8月报道】题:TET1促进IDH1野生型胆管癌的恶性进展(作者Bai X等)胆管癌(CCA)是一种高致死性疾病,缺乏有效的治疗方法。全基因组测序结果表明,约有20%的CCA患者存在IDH1突变,这些突变被认为是以依赖于2-氧戊二酸(OG)的双加氧酶为靶点促进CCA癌变。
文摘INTRODUCTIONChronic gastritis(CG)and peptic ulcer(PU)arefrequently-occurring diseases.It is now well recognizedthat Helicobacter pylori(Hp)is a major factor that leadsto CG and PU.In order to study the relationshipamong T lymphocyte subsets,NO,Hexosamine and
文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM.
文摘【据Journal of Hepatology 2021年12月报道】题:调节性T淋巴细胞和中性粒细胞胞外陷阱相互作用促进非酒精性脂肪性肝炎向肝细胞癌的转化(作者Wang H等)非酒精性脂肪性肝病(NAFLD)困扰着很大一部分西方人口,并在发展中国家迅速蔓延。非酒精性脂肪性肝炎(NASH)是NAFLD的一种侵袭性形式。在美国,10%~20%的NASH患者会发展成为终末期肝病,如肝硬化,并在5~10年内进一步发展为肝细胞癌(HCC)。迄今为止,尚无能够阻止或者逆转NASH及其并发症的有效干预手段。
