Placental site trophoblastic tumor(PSTT),a rare gestational trophoblastic neoplasm(GTN),exhibits slow growth,late-onset metastasis,and chemotherapy insensitivity[1,2].The invasive capacity of trophoblasts induces angi...Placental site trophoblastic tumor(PSTT),a rare gestational trophoblastic neoplasm(GTN),exhibits slow growth,late-onset metastasis,and chemotherapy insensitivity[1,2].The invasive capacity of trophoblasts induces angiogenesis in PSTT,yet the specific mechanism remains unclear[3].PSTT is typically resistant to chemotherapy and hysterectomy stands as the primary therapeutic choice for patients with an overall cure rate of approximately 75%-80%[4,5].Therefore,investigating the precise emergence and progression of PSTT is crucial,aiming to identify novel targets for diagnosis and therapy.展开更多
To biologically inhibit the production of highly toxic sulfide in the aquaculture area,one bacterium,designated as Hydrogenovibrio thermophilus strain TT,was isolated from sediment in Jiaozhou Bay,China.The strain was...To biologically inhibit the production of highly toxic sulfide in the aquaculture area,one bacterium,designated as Hydrogenovibrio thermophilus strain TT,was isolated from sediment in Jiaozhou Bay,China.The strain was found to be microaerobic mixtrophic,employing both carbon dioxide and organic carbons,e.g.citrate,lactate,glucose,and peptone as carbon sources.When it oxidized the sulfide and thiosulfate,oxygen was the optimal electron acceptor,followed by nitrite and nitrate,which benefited to removal of sulfide under low-oxygen mariculture environment.In addition,the strain TT exhibited remarkable tolerance of sulfide and thiosulfate in seawater,and it was able to oxidize 18.52 mmol L^-1 S^2-in 12 h or 45 mmol L^-1 S2O3^2-in 24 h at initial pH 7.0-9.0,30-40℃.Therefore,this strain showed a quite promising application for biological remediation of sulfide-contaminated mariculture system.展开更多
Sorption mechanisms of sulfamethazine(SMT)in different pH solutions are complicated.It has not been sufficiently investigated to enhance removal of SMT from alkalescent aqueous solution.In this study,sorption isotherm...Sorption mechanisms of sulfamethazine(SMT)in different pH solutions are complicated.It has not been sufficiently investigated to enhance removal of SMT from alkalescent aqueous solution.In this study,sorption isotherms and kinetics of SMT by corn biochars pyrolyzed at 300℃ and 600℃(300C,600C)under diverse pH conditions were compared.In order to improve the sorption efficiency of SMT from alkalescent aqueous solution,the biochar 300C was modified by acid or base.Different mathematic models were used to describe sorption driving force and sorption process.Results showed that the biochar 300C possessed more amorphous organic carbon and polar functional groups,which led to a higher sorption capacity than biochar 600C.The sorption rate of biochar 300C was greater than 600C under diverse pH as the physisorption of 300C outweighed 600C.The SMT presented stronger hydrophobicity at pH 5 and higher electrostatic repulsion at pH 1 or 8,which resulted in a higher combining capacity of SMT with both biochars at pH 5 than other pH values.In addition,the acid modified biochar had better removal effect on SMT than alkali at pH solution around 8.The research provides a theoretical basis for the removal of SMT from alkalescent aqueous solution.展开更多
基金supported by grants from Shanghai Municipal Commission of Health and Family Planning[grant number:20234Y0067]the National Natural Science Foundation of China[No:81971394,82371687].
文摘Placental site trophoblastic tumor(PSTT),a rare gestational trophoblastic neoplasm(GTN),exhibits slow growth,late-onset metastasis,and chemotherapy insensitivity[1,2].The invasive capacity of trophoblasts induces angiogenesis in PSTT,yet the specific mechanism remains unclear[3].PSTT is typically resistant to chemotherapy and hysterectomy stands as the primary therapeutic choice for patients with an overall cure rate of approximately 75%-80%[4,5].Therefore,investigating the precise emergence and progression of PSTT is crucial,aiming to identify novel targets for diagnosis and therapy.
基金financially supported by the Shandong Province Science and the Technology Research Projects (No. 2016GSF115004)Fundamental Research Funds for the Central Universities (No. 201964004)
文摘To biologically inhibit the production of highly toxic sulfide in the aquaculture area,one bacterium,designated as Hydrogenovibrio thermophilus strain TT,was isolated from sediment in Jiaozhou Bay,China.The strain was found to be microaerobic mixtrophic,employing both carbon dioxide and organic carbons,e.g.citrate,lactate,glucose,and peptone as carbon sources.When it oxidized the sulfide and thiosulfate,oxygen was the optimal electron acceptor,followed by nitrite and nitrate,which benefited to removal of sulfide under low-oxygen mariculture environment.In addition,the strain TT exhibited remarkable tolerance of sulfide and thiosulfate in seawater,and it was able to oxidize 18.52 mmol L^-1 S^2-in 12 h or 45 mmol L^-1 S2O3^2-in 24 h at initial pH 7.0-9.0,30-40℃.Therefore,this strain showed a quite promising application for biological remediation of sulfide-contaminated mariculture system.
基金Funds for the Central Universities of China(No.201964004)the National Natural Science Foundation of China(No.41977315).
文摘Sorption mechanisms of sulfamethazine(SMT)in different pH solutions are complicated.It has not been sufficiently investigated to enhance removal of SMT from alkalescent aqueous solution.In this study,sorption isotherms and kinetics of SMT by corn biochars pyrolyzed at 300℃ and 600℃(300C,600C)under diverse pH conditions were compared.In order to improve the sorption efficiency of SMT from alkalescent aqueous solution,the biochar 300C was modified by acid or base.Different mathematic models were used to describe sorption driving force and sorption process.Results showed that the biochar 300C possessed more amorphous organic carbon and polar functional groups,which led to a higher sorption capacity than biochar 600C.The sorption rate of biochar 300C was greater than 600C under diverse pH as the physisorption of 300C outweighed 600C.The SMT presented stronger hydrophobicity at pH 5 and higher electrostatic repulsion at pH 1 or 8,which resulted in a higher combining capacity of SMT with both biochars at pH 5 than other pH values.In addition,the acid modified biochar had better removal effect on SMT than alkali at pH solution around 8.The research provides a theoretical basis for the removal of SMT from alkalescent aqueous solution.
