免疫检查点抑制剂(immune checkpoint inhibitor,ICI)是针对机体免疫检查点的单克隆抗体。目前常用的ICI有程序性死亡受体1(programmed cell death protein 1,PD-1)抑制剂[纳武利尤单抗(nivolumab)、帕博利珠单抗(pembrolizumab)]、程...免疫检查点抑制剂(immune checkpoint inhibitor,ICI)是针对机体免疫检查点的单克隆抗体。目前常用的ICI有程序性死亡受体1(programmed cell death protein 1,PD-1)抑制剂[纳武利尤单抗(nivolumab)、帕博利珠单抗(pembrolizumab)]、程序性死亡配体1(programmed death-ligand 1,PD-L1)抑制剂[阿替利珠单抗(atezolizumab)、度伐利尤单抗(durvalumab)]及细胞毒T细胞抗原4(cytotoxic T lymphocyte-associated antigen-4,CTLA-4)抑制剂[伊匹木单抗(ipilimumab)和曲美木单抗(tremelimumab)]。展开更多
Background Idiopathic pulmonary fibrosis （IPF） is a progressive diffuse parenchymal disease with a poor prognosis.A variety of cytokines and chemokines are involved in its pathophysiology.The aim of this study was t...Background Idiopathic pulmonary fibrosis （IPF） is a progressive diffuse parenchymal disease with a poor prognosis.A variety of cytokines and chemokines are involved in its pathophysiology.The aim of this study was to evaluate the clinical features in IPF patients with the expression of suppressor of cytokine signaling 1 （SOCS-1）,which acts as a negative regulator of cytokine signaling.Methods IPF patients （n=20） and healthy controls （n=16） were included in this study.The expression of SOCS-1 was analyzed in peripheral blood mononuclear cells （PBMC） of subjects using RT-PCR.Interleukin 4 （IL-4）,transforming growth factor β1 （TGF-β1） and type Ⅰ collagen expression were also analyzed in each individual using enzyme-linked immunosorbent assay （ELISA）.The clinical characteristics of IPF patients were delineated.These results were analyzed by SPSS13.0 statistics software.Results SOCS-1 mRNA expression was significantly decreased in the PBMC of IPF patients compared with healthy controls; serum levels of IL-4 and TGF-β1 were higher in IPF patients.The patients with lower expression of SOCS-1 developed lower percentage of forced vital capacity （FVC%） and DLCO/VA.A patients＇ SOCS-1 mRNA level was negatively correlated with serum levels of IL-4,and negatively correlated with their high-resolution computed tomography （HRCT） scores.Conclusions SOCS-1 mRNA can be detected in PBMC,and it is down-regulated in IPF patients.The expression of SOCS-1 is associated with the severity of IPF patients＇ symptoms,so it might be the predictor of disease severity.SOCS-1 might play an important role in IPF by reducing the expression of the T helper type 2 （Th2） cell-related cytokine IL-4.展开更多
文摘免疫检查点抑制剂(immune checkpoint inhibitor,ICI)是针对机体免疫检查点的单克隆抗体。目前常用的ICI有程序性死亡受体1(programmed cell death protein 1,PD-1)抑制剂[纳武利尤单抗(nivolumab)、帕博利珠单抗(pembrolizumab)]、程序性死亡配体1(programmed death-ligand 1,PD-L1)抑制剂[阿替利珠单抗(atezolizumab)、度伐利尤单抗(durvalumab)]及细胞毒T细胞抗原4(cytotoxic T lymphocyte-associated antigen-4,CTLA-4)抑制剂[伊匹木单抗(ipilimumab)和曲美木单抗(tremelimumab)]。
基金This study was supported by the grants from Science and Technology Commission of Shanghai，National Natural Science Foundation
文摘Background Idiopathic pulmonary fibrosis （IPF） is a progressive diffuse parenchymal disease with a poor prognosis.A variety of cytokines and chemokines are involved in its pathophysiology.The aim of this study was to evaluate the clinical features in IPF patients with the expression of suppressor of cytokine signaling 1 （SOCS-1）,which acts as a negative regulator of cytokine signaling.Methods IPF patients （n=20） and healthy controls （n=16） were included in this study.The expression of SOCS-1 was analyzed in peripheral blood mononuclear cells （PBMC） of subjects using RT-PCR.Interleukin 4 （IL-4）,transforming growth factor β1 （TGF-β1） and type Ⅰ collagen expression were also analyzed in each individual using enzyme-linked immunosorbent assay （ELISA）.The clinical characteristics of IPF patients were delineated.These results were analyzed by SPSS13.0 statistics software.Results SOCS-1 mRNA expression was significantly decreased in the PBMC of IPF patients compared with healthy controls; serum levels of IL-4 and TGF-β1 were higher in IPF patients.The patients with lower expression of SOCS-1 developed lower percentage of forced vital capacity （FVC%） and DLCO/VA.A patients＇ SOCS-1 mRNA level was negatively correlated with serum levels of IL-4,and negatively correlated with their high-resolution computed tomography （HRCT） scores.Conclusions SOCS-1 mRNA can be detected in PBMC,and it is down-regulated in IPF patients.The expression of SOCS-1 is associated with the severity of IPF patients＇ symptoms,so it might be the predictor of disease severity.SOCS-1 might play an important role in IPF by reducing the expression of the T helper type 2 （Th2） cell-related cytokine IL-4.
