The perineuronal nets(PNNs)are a kind of extracellular matrix structure which mainly surround parvalbumin-positive(PV^(+))GABAergic interneurons.The aim of this study is to investigate the role of PNNs in the medial p...The perineuronal nets(PNNs)are a kind of extracellular matrix structure which mainly surround parvalbumin-positive(PV^(+))GABAergic interneurons.The aim of this study is to investigate the role of PNNs in the medial prefrontal cortex(mPFC)in the antidepressant effect of electroacupuncture treatment.Adult rats underwent chronic unpredictable mild stress(CUMS)for 28 days,and electroacupuncture treatment of Baihui and Yintang acupoints was administrated from day 8 to day 28.Then we detected the depressive-and anxiety like behavior of rats,the density of PNNs,the percentage of PV^(+)neurons that surround PNNs,the expression levels of PNNs constituting proteins in the mPFC.展开更多
文摘The perineuronal nets(PNNs)are a kind of extracellular matrix structure which mainly surround parvalbumin-positive(PV^(+))GABAergic interneurons.The aim of this study is to investigate the role of PNNs in the medial prefrontal cortex(mPFC)in the antidepressant effect of electroacupuncture treatment.Adult rats underwent chronic unpredictable mild stress(CUMS)for 28 days,and electroacupuncture treatment of Baihui and Yintang acupoints was administrated from day 8 to day 28.Then we detected the depressive-and anxiety like behavior of rats,the density of PNNs,the percentage of PV^(+)neurons that surround PNNs,the expression levels of PNNs constituting proteins in the mPFC.
