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红景天苷对血管性痴呆大鼠学习记忆能力的改善作用及机制研究 被引量:8
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作者 王金华 张叶青 +2 位作者 陶涛涛 柯博熙 张丹红 《浙江医学》 CAS 2019年第3期234-237,共4页
目的探讨红景天苷对血管性痴呆(VD)大鼠学习记忆能力的改善作用及相关机制。方法采用随机数字表法将42只大鼠分为对照组、模型组和红景天苷组3组,对照组大鼠12只,模型组和红景天苷组各15只。模型组和红景天苷组采用双侧颈总动脉结扎法制... 目的探讨红景天苷对血管性痴呆(VD)大鼠学习记忆能力的改善作用及相关机制。方法采用随机数字表法将42只大鼠分为对照组、模型组和红景天苷组3组,对照组大鼠12只,模型组和红景天苷组各15只。模型组和红景天苷组采用双侧颈总动脉结扎法制作VD模型。红景天苷组大鼠于造模后7d给予红景天苷10mg/kg (1.5g溶于1L 0.9%氯化钠溶液,6.7ml/kg)灌胃治疗;对照组和模型组大鼠给予0.9%氯化钠溶液(6.7ml/kg)灌胃,3组均为1次/d,连续4周。采用水迷宫实验检测大鼠认知功能;采用ELISA法检测大鼠脑组织海马丙二醛(MDA)、TNF-α、IL-6水平和超氧化物歧化酶(SOD)活性。结果与对照组大鼠相比,模型组和红景天苷组大鼠逃避潜伏期均延长,目标象限停留时间均缩短,海马MDA、TNF-α和IL-6水平均升高,SOD活性均降低,差异均有统计学意义(均P<0.05);与模型组大鼠相比,红景天苷组大鼠逃避潜伏期缩短,目标象限停留时间延长,海马MDA、TNF-α和IL-6水平均降低,SOD活性升高,差异均有统计学意义(均P<0.05)。结论红景天苷可明显改善VD大鼠空间认知功能的损害,其发挥神经保护作用的机制可能与其抗炎、抗氧化应激损伤作用密切相关。 展开更多
关键词 血管性痴呆 红景天苷 认知功能 炎症因子 氧化应激
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Zircon U-Pb Ages of Bottom and Top Parts of the Zhangjiakou Formation in Lingyuan Area(West Liaoning Province) and Luanping Area (North Hebei Province) and Their Significance 被引量:3
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作者 ZhangHong LiuXiaoming +3 位作者 zhangyeqing YuanHonglin HuZhaochu DiwuChunrong 《Journal of China University of Geosciences》 SCIE CSCD 2005年第2期115-129,共15页
In Lingyuan region of West Liaoning Province, the Zhangjiakou Formation (J_3z) and the Yixian Formation (K_1y) display an angular unconformity. That is, the Lower Mesozoic strata of the Zhangjiakou Formation are ENE (... In Lingyuan region of West Liaoning Province, the Zhangjiakou Formation (J_3z) and the Yixian Formation (K_1y) display an angular unconformity. That is, the Lower Mesozoic strata of the Zhangjiakou Formation are ENE (near E-W) oriented, while the overlying strata of the Yixian Formation exhibit an NNE orientation. The results of LA-ICP-MS zircon U-Pb ages show the Zhangjiakou Formation formed from about 130 Ma to 132 Ma in Lingyuan and 135 Ma to 136 Ma in Luanping (North Hebei Province), respectively. Three conclusions can be drawn: (1) The Zhangjiakou Formation in Lingyuan is comparable to that in Luanping, with the volcanic rocks of the Zhangjiakou Formation from Lingyuan being younger than those from Luanping. (2) 5-6 Ma difference between the top of the Zhangjiakou Formation and the bottom of the Yixian Formation in Lingyuan proves the angular unconformity between the two formations; and it reflects that the 5-6 Ma interval period is the main period of the transition of tectonic framework in Mesozoic in North Hebei and West Liaoning. In the interval period, the magmatic action went up to high tide in Mesozoic in the northeast of China. Moreover, after the interval period, the “Rehe fauna” developed into “erupted” period. This reflects that the interval period is also an important biological interface in Northern Hebei and Western Liaoning. (3) The Dabeigou Formation in Luanping should correspond to the upper part of the Zhangjiakou Formation, but not to the lower part of the Yixian Formation. 展开更多
关键词 zircon U-Pb age Zhangjiakou Formation bottom and top bed Luanping and Lingyuan regions
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