Integrated multimodal imaging in theranostics nanomaterials offers extensive prospects for precise and noninvasive cancer treatment.Precisely controlling the structural evolution of plasmonic nanoparticles is crucial ...Integrated multimodal imaging in theranostics nanomaterials offers extensive prospects for precise and noninvasive cancer treatment.Precisely controlling the structural evolution of plasmonic nanoparticles is crucial in the development of pho-tothermal agents.However,previous successes have been limited to static assemblies and single-component structures.Here,an activatable plasmonic theranostics system utilizing self-assembled 1D silver-coated gold nanochains(1D nanochains)is pre-sented for precise tumor diagnosis and effective treatment.The absorbance of the adaptable core–shell chain structure can shift from visible to near-infrared(NIR)regions due to the fusion between nearby Au@Ag nanoparticles induced by ele-vated H2O2 levels in the tumor microenvironment(TME),resulting in the creation of a novel 3D aggregates with strong NIR absorption.With a high photothermal conversion efficiency of 60.2%at 808 nm,nanochains utilizing the TME-activated characteristics show remarkable qualities for photoacoustic imaging and signifi-cantly limit tumor growth in vivo.This study may pave the way for precise tumor diagnosis and treatment through customizable,optically tunable adaptive plasmonic nanostructures.展开更多
基金Chinese Academy of Sciences,Grant/Award Number:ZDBS-LY-SLH036CAMS Innovation Fund for Medical Sciences,Grant/Award Number:2023-I2M-3-009+1 种基金Science and Technology Support Program of Jiangsu Province,Grant/Award Number:BZ2022056Ministry of Education-Singapore,Grant/Award Number:Tier 1 A-8000013-00-00。
文摘Integrated multimodal imaging in theranostics nanomaterials offers extensive prospects for precise and noninvasive cancer treatment.Precisely controlling the structural evolution of plasmonic nanoparticles is crucial in the development of pho-tothermal agents.However,previous successes have been limited to static assemblies and single-component structures.Here,an activatable plasmonic theranostics system utilizing self-assembled 1D silver-coated gold nanochains(1D nanochains)is pre-sented for precise tumor diagnosis and effective treatment.The absorbance of the adaptable core–shell chain structure can shift from visible to near-infrared(NIR)regions due to the fusion between nearby Au@Ag nanoparticles induced by ele-vated H2O2 levels in the tumor microenvironment(TME),resulting in the creation of a novel 3D aggregates with strong NIR absorption.With a high photothermal conversion efficiency of 60.2%at 808 nm,nanochains utilizing the TME-activated characteristics show remarkable qualities for photoacoustic imaging and signifi-cantly limit tumor growth in vivo.This study may pave the way for precise tumor diagnosis and treatment through customizable,optically tunable adaptive plasmonic nanostructures.
