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2023年度肿瘤学科基金项目申请和评审工作综述
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作者 张占国 李璞 +5 位作者 王建波 邢晓芳 温韬 张卫杰 姚刚 石嵘 《中国科学基金》 CSCD 北大核心 2024年第1期81-85,共5页
2023年国家自然科学基金的各项评审工作已经结束,本文梳理了2023年度医学科学部七处(以下简称“医学七处”)基金项目受理和评审情况,有助于肿瘤学科领域科研工作者对医学七处资助领域的总体情况有所了解,并为2024年度拟在医学七处申报... 2023年国家自然科学基金的各项评审工作已经结束,本文梳理了2023年度医学科学部七处(以下简称“医学七处”)基金项目受理和评审情况,有助于肿瘤学科领域科研工作者对医学七处资助领域的总体情况有所了解,并为2024年度拟在医学七处申报项目的申请人提供参考。 展开更多
关键词 国家自然科学基金 医学科学 肿瘤学科 评审工作 综述
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Genetic variation in GmCRP contributes to nodulation in soybean(Glycine max Merr.) 被引量:1
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作者 Jinhui Wang Chao Ma +11 位作者 Shengnan Ma Haiyang Zheng Huilin Tian Xi Wang Yue Wang Hongwei Jiang Jiangxu Wang zhanguo zhang Chunyan Liu Mingliang Yang Qingshan Chen Dawei Xin 《The Crop Journal》 SCIE CSCD 2023年第2期332-344,共13页
Symbiosis between soybean and rhizobia contributes to soybean yield and quality. Although secreted rhizobial type Ⅲ effectors are known to regulate infection and promote nitrogen fixation, much about them remains unk... Symbiosis between soybean and rhizobia contributes to soybean yield and quality. Although secreted rhizobial type Ⅲ effectors are known to regulate infection and promote nitrogen fixation, much about them remains unknown. Mutation of NopC, a type Ⅲ effector from Sinorhizobium fredii HH103, reduced nodule numbers and dry weights in 310 soybean accessions, and expression of NopC in soybean hairy roots promoted symbiosis. Based on observed differences in nodule traits between Suinong 14 and Zyd 00,006inoculated with HH103 and the NopC mutant, 11 QTL associated with rhizobia were identified in chromosome segment substitution lines(CSSLs) derived from Suinong 14 and Zyd 00006. Using chromosome fragment insertion, whole-genome sequencing of Suinong 14 and Zyd 00006, and qRT-PCR,Glyma.19G176300(GmCRP) was identified as a candidate gene associated with NopC, and GmCRP was found to be induced by NopC to positively regulate nodulation. SNPs located in the regulatory regions of GmCRP influenced its expression response to NopC, with SNPs contributing to nodulation having been selected during domestication. Our findings reveal the function of a soybean gene encoding a rhizobial type Ⅲ effector that contributes to symbiosis, and will facilitate the practical application of symbiotic nitrogen fixation in molecular breeding. 展开更多
关键词 SOYBEAN SYMBIOSIS EFFECTOR NopC Natural varieties
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A new tumor-associated antigen prognostic scoring system for spontaneous ruptured hepatocellular carcinoma after partial hepatectomy 被引量:4
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作者 Jingjing Wu Peng Zhu +7 位作者 zhanguo zhang Bixiang zhang Chang Shu Lin Chen Renjie Feng Abdoul aziz Mba'nbo koumpa Ganxun Li Qianyun Ge 《Cancer Biology & Medicine》 SCIE CAS CSCD 2018年第4期415-424,共10页
Objective:Spontaneous hepatocellular carcinoma(HCC)rupture can be fatal,and hepatic resection could achieve a favorable long-term survival among all strategies of tumor rupture.However,there is no available prognostic... Objective:Spontaneous hepatocellular carcinoma(HCC)rupture can be fatal,and hepatic resection could achieve a favorable long-term survival among all strategies of tumor rupture.However,there is no available prognostic scoring system for patients with ruptured HCC who underwent partial hepatectomy.Methods:From January 2005 to May 2015,129 patients with spontaneous HCC rupture underwent partial hepatectomy.Preoperative clinical data were collected and analyzed.Independent risk factors affecting overall survival(OS)were used to develop the new scoring system.Harrell’s C statistics,Akaike information criterion(AIC),the relative likelihood,and the log likelihood ratio were calculated to measure the homogeneity and discriminatory ability of a prognostic system.Results:In the multivariable Cox regression analysis,three factors,including tumor size,preoperativeα-fetoprotein level,and alkaline phosphatase level,were chosen for the new tumor-associated antigen(TAA)prognostic scoring system.The 1-year OS rates were 88.1%,43.2%,and 30.2%for TAA scores of 0–5 points(low-risk group),6–9 points(moderate-risk group),and 10–13points(high-risk group),respectively.The TAA scoring system had superior homogeneity and discriminatory ability(Harrell’s C statistics,0.693 vs.0.627 and 0.634;AIC,794.79 vs.817.23 and 820.16;relative likelihood,both<0.001;and log likelihood ratio,45.21 vs.22.77 and 21.84)than the Barcelona Clinic Liver Cancer staging system and the Cancer of the Liver Italian Program in predicting OS.Similar results were found while predicting disease-free survival(DFS).Conclusions:The new prognostic scoring system is simple and effective in predicting both OS and DFS of patients with spontaneous ruptured HCC. 展开更多
关键词 Spontaneous RUPTURE PROGNOSTIC SCORING system HOMOGENEITY discriminatory ability overall SURVIVAL disease-free SURVIVAL HEPATOCELLULAR carcinoma
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Comparison of the activities of binder-added and binder-free Mo/HZSM-5 catalysts in methane dehydroaromatization at 1073 K in periodic CH_4-H_2 switch operation mode 被引量:7
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作者 Yuebing Xu Hongtao Ma +2 位作者 Yo Yamamoto Yoshizo Suzuki zhanguo zhang 《Journal of Natural Gas Chemistry》 EI CAS CSCD 2012年第6期729-744,共16页
Three industry-supplied, well-shaped Mo/HZSM-5 catalysts, two binder-added and one binder-free, were tested for the first time in methane dehydroaromatization to benzene at 1073 K and 10000 mL/(g·h) in periodic... Three industry-supplied, well-shaped Mo/HZSM-5 catalysts, two binder-added and one binder-free, were tested for the first time in methane dehydroaromatization to benzene at 1073 K and 10000 mL/(g·h) in periodic CH4-H2 switch operation mode, and their catalytic performances were compared with those of three self-prepared, binder-free powder Mo/HZSM-5 catalysts. XRD, 27Al NMR, SEM, BET and NH3-TPD characterizations of all the catalysts show that the zeolites in the two binder-added catalysts are comparable to those in the three binder-free powder catalysts in crystallinity, crystal size, micropore volume and Br{/o}nsted acidity. The test results, on the other hand, show that the catalytic performances of the two binder-added catalysts are worse than those of the four binder-free catalysts on both catalyst mass and zeolite mass bases. Then, TPO and BET measurements of all spent samples were conducted to get a deep insight into the negative effects of binder addition, and the results suggest that the binder additives functioned mainly to enhance the polyaromatization of formed aromatics to coke on their external surfaces and consequently lower the catalysts' benzene formation activity and selectivity. 展开更多
关键词 methane dehydroaromatization MO/HZSM-5 BINDER coke formation
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Development of a CH4 dehydroaromatization–catalyst regeneration fluidized bed system 被引量:5
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作者 Peng Yan zhanguo zhang +5 位作者 Dapeng Li Xu Cheng Xinzhuang zhang Fan Yang Chuanfeng Huang Xiaoxun Ma 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2018年第9期1928-1936,共9页
A pilot-scale methane dehydroaromatization–H_2regeneration fluidized bed system(MDARS)was developed.In the MDARS,the catalyst circulation between a fluidized bed reactor and a fluidized bed regenerator with the help ... A pilot-scale methane dehydroaromatization–H_2regeneration fluidized bed system(MDARS)was developed.In the MDARS,the catalyst circulation between a fluidized bed reactor and a fluidized bed regenerator with the help of a catalyst feeder allowed methane dehydroaromatization(MDA)and H_2regeneration to be carried out simultaneously,which is good for maintaining a stable MDA catalytic activity.A fixed bed reactor(FB)and a single fluidized bed reactor(SFB)were also used for a comparative study.The experimental results showed that the catalytic activity in the MDARS was more stable than that in the FB and SFB reactors.The effects of some parameters of MDARS on the CH_4conversion and product selectivity were investigated.To verify the feasibility and reliability of the MDARS,an eight-hour long-term test was carried out,which demonstrated that the operation of the MDARS was stable and that the catalytic activity remained stable throughout the entire experimental period. 展开更多
关键词 Methane dehydroaromatization Hydrogen regeneration Fluidized bed reactor PILOT-SCALE Catalyst circulation
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Study on attrition of spherical-shaped Mo/HZSM-5 catalyst for methane dehydro-aromatization in a gas–solid fluidized bed 被引量:3
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作者 Xinzhuang zhang Yunda Han +2 位作者 Dapeng Li zhanguo zhang Xiaoxun Ma 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第10期172-183,共12页
As a potential methane efficient conversion process,non-oxidative aromatization of methane in fluidized bed requires a catalyst with good attrition resistance,especially in the states of high temperature,longtime rapi... As a potential methane efficient conversion process,non-oxidative aromatization of methane in fluidized bed requires a catalyst with good attrition resistance,especially in the states of high temperature,longtime rapid movement and chemical reaction.Existing evaluation methods for attrition resistance,such as ASTM D5757 and Jet Cup test,are targeted for fresh catalysts at ambient temperature,which cannot well reflect the real process.In this study,spherical-shaped Mo/HZSM-5 catalyst prepared by dipping and spray drying was placed in a self-made apparatus for attrition testing,in which the catalyst attrition under different system temperatures,running time and process factors was investigated with percent mass loss(PML),particle size-mass distribution(PSMD)and scanning electron microscope(SEM).Carbon deposition on the catalyst before and after activation,aromatization and regeneration was analyzed by thermogravimetry(TG),and the attrited catalysts were evaluated for methane dehydro-aromatization(MDA).The results show that the surface abrasion and body breakage of catalyst particles occur continuously,with the increase of system temperature and running time,and make the PML rise gradually.The process factors of activation,aromatization and regeneration can cause the catalyst attrition and carbon deposits,which broaden the PSMD in varying degrees,and the carbon-substances on catalysts greatly improve their attrition resistance at high temperature.Catalyst attrition has a certain influence on its catalytic performance,and the main reasons point to particle breakage and fine powder escape. 展开更多
关键词 Attrition MO/HZSM-5 FLUIDIZED-BED Catalyst activation Methane dehydro-aromatization
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SPM-IS: An auto-algorithm to acquire a mature soybean phenotype based on instance segmentation 被引量:3
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作者 Shuai Li Zhuangzhuang Yan +8 位作者 Yixin Guo Xiaoyan Su Yangyang Cao Bofeng Jiang Fei Yang zhanguo zhang Dawei Xin Qingshan Chen Rongsheng Zhu 《The Crop Journal》 SCIE CSCD 2022年第5期1412-1423,共12页
Mature soybean phenotyping is an important process in soybean breeding;however, the manual process is time-consuming and labor-intensive. Therefore, a novel approach that is rapid, accurate and highly precise is requi... Mature soybean phenotyping is an important process in soybean breeding;however, the manual process is time-consuming and labor-intensive. Therefore, a novel approach that is rapid, accurate and highly precise is required to obtain the phenotypic data of soybean stems, pods and seeds. In this research, we propose a mature soybean phenotype measurement algorithm called Soybean Phenotype Measure-instance Segmentation(SPM-IS). SPM-IS is based on a feature pyramid network, Principal Component Analysis(PCA) and instance segmentation. We also propose a new method that uses PCA to locate and measure the length and width of a target object via image instance segmentation. After 60,000 iterations, the maximum mean Average Precision(m AP) of the mask and box was able to reach 95.7%. The correlation coefficients R^(2) of the manual measurement and SPM-IS measurement of the pod length, pod width, stem length, complete main stem length, seed length and seed width were 0.9755, 0.9872, 0.9692, 0.9803,0.9656, and 0.9716, respectively. The correlation coefficients R^(2) of the manual counting and SPM-IS counting of pods, stems and seeds were 0.9733, 0.9872, and 0.9851, respectively. The above results show that SPM-IS is a robust measurement and counting algorithm that can reduce labor intensity, improve efficiency and speed up the soybean breeding process. 展开更多
关键词 SOYBEAN Feature pyramid network PCA Instance segmentation Deep learning
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Incomplete radiofrequency ablation provokes colorectal cancer liver metastases through heat shock response by PKCα/Fra-1 pathway 被引量:2
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作者 zhanguo zhang Yuxin zhang +5 位作者 Lei zhang Youliang Pei Yanhui Wu Huifang Liang Wanguang zhang Bixiang zhang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2019年第3期542-555,共14页
Objective: Incomplete radiofrequency ablation(ICR) has been proposed as a major cause of recurrence in the treatment of hepatic metastatic tumors.We tried to determine the mechanisms of this progression in colorectal ... Objective: Incomplete radiofrequency ablation(ICR) has been proposed as a major cause of recurrence in the treatment of hepatic metastatic tumors.We tried to determine the mechanisms of this progression in colorectal cancer(CRC) liver metastasis(CRLMs)Methods: We have established a mouse model of radiofrequency ablation(RFA) therapy to demonstrate increased risk of recurrence of CRLMs with ICR.Here we focused on heat shock-induced CRC malignancy.Sub-lethal heat shock(HS) in CRC cell lines provoked cell growth, invasion, and tumor initiation in vitro and in vivo.Results: We found that Fra-1, which lies downstream of PKCα-ERK1/2 signaling, was significantly increased by HS compared with the untreated CRC cells.Silencing Fra-1 reversed the tumor promoting effects of HS.Furthermore, proliferation and tumor initiation inducer c-Myc, together with tumor invasion inducer matrix-metalloprotase 1(MMP-1) expression were up-regulated by AP-1/Fra-1 induced genes transcription.Conclusions: Our study demonstrated that ICR generated HS induces CRC malignancy by targeting Fra-1, which could be a potential prognostic marker and a promising therapeutic strategy to prevent disease recurrence after radiofrequency ablation treatment. 展开更多
关键词 RADIOFREQUENCY ablation heat shock colorectal CANCER liver METASTASES CANCER stem cells recurrence
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GmGPDH12,a mitochondrial FAD-GPDH from soybean, increases salt and osmotic stress resistance by modulating redox state and respiration 被引量:2
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作者 Ying Zhao Xin Li +11 位作者 Zexin zhang Wenjing Pan Sinan Li Yun Xing Wanying Xin zhanguo zhang Zhenbang Hu Chunyan Liu Xiaoxia Wu Zhaoming Qi Dawei Xin Qingshan Chen 《The Crop Journal》 SCIE CSCD 2021年第1期79-94,共16页
In plants,glycerol-3-phosphate dehydrogenase(GPDH)catalyzes the interconversion of glycerol-3-phosphate(G3P)and dihydroxyacetone phosphate(DHAP)coupled to the reduction/oxidation of the nicotinamide adenine dinucleoti... In plants,glycerol-3-phosphate dehydrogenase(GPDH)catalyzes the interconversion of glycerol-3-phosphate(G3P)and dihydroxyacetone phosphate(DHAP)coupled to the reduction/oxidation of the nicotinamide adenine dinucleotide(NADH)pool,and plays a central role in glycerolipid metabolism and stress response.Previous studies have focused mainly on the NAD+-dependent GPDH isoforms,neglecting the role of flavin adenine dinucleotide(FAD)-dependent GPDHs.We isolated and characterized three mitochondrialtargeted FAD-GPDHs in soybean,of which one isoform(GmGPDH12)showed a significant transcriptional response to NaCl and mannitol treatments,suggesting the existence of a major FAD-GPDH isoform acting in soybean responses to salt and osmotic stress.An enzyme kinetic assay showed that the purified GmGPDH12 protein possessed the capacity to oxidize G3P to DHAP in the presence of FAD.Overexpression and RNA interference of GmGPDH12 in soybean hairy roots resulted in elevated tolerance and sensitivity to salt and osmotic stress,respectively.G3P contents were significantly lower in GmGPDH12-overexpressing hair roots and higher in knockdown hair roots,indicating that GmGPDH12 was essential for G3P catabolism.A significant perturbation in redox status of NADH,ascorbic acid(ASA)and glutathione(GSH)pools was observed in GmGPDH12-knockdown plants under stress conditions.The impaired redox balance was manifested by higher reactive oxygen species generation and consequent cell damage or death;however,overexpressing plants showed the opposite results for these traits.GmGPDH12 overexpression contributed to maintaining constant respiration rates under salt or osmotic stress by regulating mRNA levels of key mitochondrial respiratory enzymes.This study provides new evidence for the roles of mitochondria-localized GmGPDH12 in conferring resistance to salt or osmotic stress by maintaining cellular redox homeostasis,protecting cells and respiration from oxidative injury. 展开更多
关键词 Redox homeostasis Respiration characteristics GmGPDH12 Salt stress Osmotic stress
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二氧化碳甲烷化催化剂及反应机理研究进展 被引量:4
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作者 田郡博 古芳娜 +2 位作者 苏发兵 张战国 许光文 《过程工程学报》 CAS CSCD 北大核心 2023年第3期375-395,共21页
在“双碳”目标的背景下,明确碳处理路径至关重要。利用可再生能源制得的氢,将二氧化碳(CO_(2))通过甲烷化反应制备合成天然气(SNG)被广泛认为是一种高效、有前景的碳捕集利用技术,有望实现碳循环利用。近年来,二氧化碳甲烷化催化剂及... 在“双碳”目标的背景下,明确碳处理路径至关重要。利用可再生能源制得的氢,将二氧化碳(CO_(2))通过甲烷化反应制备合成天然气(SNG)被广泛认为是一种高效、有前景的碳捕集利用技术,有望实现碳循环利用。近年来,二氧化碳甲烷化催化剂及相关反应机理均取得了许多新进展。鉴于此,本工作对该反应进行了系统的综述。首先,介绍了CO_(2)甲烷化反应的热力学研究中不同反应条件的影响;随后从活性金属、载体、制备方法及辅助技术等四方面介绍了CO_(2)甲烷化催化剂的研究进展,其中活性组分包括非贵金属基(Ni,Fe,Co和Mo)和贵金属基(Ru,Rh,Pt和Pd),载体包括传统氧化物(Al2O3,SiO_(2),TiO_(2),ZrO_(2)和CeO_(2))和新型载体材料(金属有机框架和碳基材料),催化剂制备方法包括传统制备方法(浸渍法、共沉淀法、水热法、溶胶-凝胶法和固相合成法)和合成辅助技术(超声波、微波和等离子体等);总结了CO_(2)甲烷化反应遵循的两条机理路径(甲酸盐路径和CO路径),并指出CO_(2)甲烷化的具体反应途径与催化剂表面特性(如羟基丰富度和O_(2)-位点)和反应条件(如反应温度和压力)相关;最后提出了当前研究存在的挑战,并对研究前景作出展望。 展开更多
关键词 CO_(2)甲烷化 热力学 催化剂 制备方法 反应机理
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Combination Therapies for Advanced Biliary Tract Cancer 被引量:4
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作者 Weifeng Zeng Ruiqi Mao +1 位作者 zhanguo zhang Xiaoping Chen 《Journal of Clinical and Translational Hepatology》 SCIE 2023年第2期490-501,共12页
Biliary tract cancers(BTCs)are a group of malignant neoplasms that have recently increased in incidence and have a poor prognosis.Surgery is the only curative therapy.However,most patients are only indicated for palli... Biliary tract cancers(BTCs)are a group of malignant neoplasms that have recently increased in incidence and have a poor prognosis.Surgery is the only curative therapy.However,most patients are only indicated for palliative therapy because of advanced-stage disease at diagnosis and rapid progression.The current first-line treatment for advanced BTC is gemcitabine and cisplatin chemotherapy.Nonetheless,many patients develop resistance to this regimen.Over the years,few chemotherapy regimens have managed to improve the overall survival of patients.Accordingly,novel therapies such as targeted therapy have been introduced to treat this patient population.Extensive research on tumorigenesis and the genetic profiling of BTC have revealed the heterogenicity and potential target pathways,such as EGFR,VEGF,MEK/ERK,PI3K and mTOR.Moreover,mutational analysis has documented the presence of IDH1,FGFR2,HER2,PRKACA,PRKACB,BRAF,and KRAS gene aberrations.The emergence of immunotherapy in recent years has expanded the treatment landscape for this group of malignancies.Cancer vaccines,adoptive cell transfer,and immune checkpoint inhibitors have been extensively investigated in trials of BTC.Therefore,patient stratification and a combination of various therapies have become a reasonable and important clinical strategy to improve patient outcomes.This review elaborates the literature on combined treatment strategies for advanced BTC from the past few years and ongoing clinical trials to provide new inspiration for the treatment of advanced BTC. 展开更多
关键词 Biliary tract cancer Drug therapy Combination IMMUNOTHERAPY Molecular targeted therapy Clinical trials
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Enhanced production of seed oil with improved fatty acid composition by overexpressing NAD^(+)-dependent glycerol-3-phosphate dehydrogenase in soybean 被引量:4
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作者 Ying Zhao Pan Cao +18 位作者 Yifan Cui Dongxu Liu Jiapeng Li Yabin Zhao Siqi Yang Bo zhang Runnan Zhou Minghao Sun Xuetian Guo Mingliang Yang Dawei Xin zhanguo zhang Xin Li Chen Lv Chunyan Liu Zhaoming Qi Jingyu Xu Xiaoxia Wu Qingshan Chen 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2021年第6期1036-1053,共18页
There is growing interest in expanding the production of soybean oils(mainly triacylglycerol, or TAG) to meet rising feed demand and address global energy concerns. We report that a plastidlocalized glycerol-3-phospha... There is growing interest in expanding the production of soybean oils(mainly triacylglycerol, or TAG) to meet rising feed demand and address global energy concerns. We report that a plastidlocalized glycerol-3-phosphate dehydrogenase(GPDH), encoded by GmGPDHp1 gene, catalyzes the formation of glycerol-3-phosphate(G3 P), an obligate substrate required for TAG biosynthesis.Overexpression of GmGPDHp1 increases soybean seed oil content with high levels of unsaturated fatty acids(FAs), especially oleic acid(C18:1), without detectably affecting growth or seed protein content or seed weight. Based on the lipidomic analyses, we found that the increase in G3 P content led to an elevated diacylglycerol(DAG) pool, in which the Kennedy pathwayderived DAG was mostly increased, followed by PC-derived DAG, thereby promoting the synthesis of TAG containing relatively high proportion of C18:1. The increased G3 P levels induced several transcriptional alterations of genes involved in the glycerolipid pathways. In particular, genes encoding the enzymes responsible for de novo glycerolipid synthesis were largely upregulated in the transgenic lines, in-line with the identified biochemical phenotype. These results reveal a key role for GmGPDHp1-mediated G3 P metabolism in enhancing TAG synthesis and demonstrate a strategy to modify the FA compositions of soybean oils for improved nutrition and biofuel. 展开更多
关键词 GmGPDHp1 G3P production LIPIDOMICS oil accumulation SOYBEAN TRANSCRIPTOMICS
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Development of highly active coated monolith SCR catalyst with strong abrasion resistance for low-temperature application 被引量:4
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作者 Lina GAN Shan LEI +5 位作者 Jian YU Hongtao MA Yo YAMAMOTO Yoshizo SUZUKI Guangwen XU zhanguo zhang 《Frontiers of Environmental Science & Engineering》 SCIE EI CAS CSCD 2015年第6期979-987,共9页
Monolith SCR catalysts coated with V2Os- WO3/TiO2 were prepared by varying binder and coating thickness. Comparing with a monolith extruded with 100% V2O5-WO3/TiO2 powder, a coated monolith with a catalyst-coating lay... Monolith SCR catalysts coated with V2Os- WO3/TiO2 were prepared by varying binder and coating thickness. Comparing with a monolith extruded with 100% V2O5-WO3/TiO2 powder, a coated monolith with a catalyst-coating layer of 260 μm in thickness exhibited the similar initial NOx reduction activity at 250℃. After 4 h abrasion (attrition) in an air stream containing 300 g. m^-3 fine sands (50-100μm) at a superficial gas velocity of 10m·s^-1, the catalyst still has the activity as a 100% molded monolith does in a 24-h activity test and it retains about 92% of its initial activity at 250℃. Estimation of the equivalent durable hours at a fly ash concentration of 1.0 g.m^-3 in flue gas and a gas velocity of 5 m.s^-1 demonstrated that this coated monolith catalyst is capable of resisting abrasion for 13 months without losing more than 8% of its initial activity. The result suggests the great potential of the coated monolith for application to de-NOx of flue gases with low fly ash concentrations from, such as glass and ceramics manufacturing processes. 展开更多
关键词 coated monolith low-temperature denitration abrasion resistance attrition
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From fundamentals to chemical engineering on oxidative coupling of methane for ethylene production:A review 被引量:1
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作者 Jiao Liu Junrong Yue +4 位作者 Mei Lv Fang Wang Yanbin Cui zhanguo zhang Guangwen Xu 《Carbon Resources Conversion》 2022年第1期1-14,共14页
A comprehensive overview is presented to summarize the research works since 1982 on oxidative coupling of methane(OCM),a complex reaction network combining heterogeneous and homogeneous reaction steps.Fundamentals on ... A comprehensive overview is presented to summarize the research works since 1982 on oxidative coupling of methane(OCM),a complex reaction network combining heterogeneous and homogeneous reaction steps.Fundamentals on reaction mechanisms and thermodynamics have revealed that the OCM process is highly exothermic and its C2+selectivity and yield is critical in evaluating its commercial viability.Catalytic strategies have been put to enhance C2+selectivity,improve C2+yield and lower reaction temperature.The catalyst MnNa2WO4/SiO2 enables methane activation at a temperature of 800◦C and simultaneously a high C2+selectivity of 70–80%,while the nanowire and La2O3-based catalysts enable to lower the reaction temperature to 200–300◦C and 500◦C,respectively.Reaction engineering aspects have also been dealt in many investigations in order to make the process technically feasible.Particularly,research works on reaction kinetics,reactor selection and reactor operating mode choice have been addressed.Intermediate cooling and distributed oxygen feed have been integrated into a multi-stage adiabatic fixed-bed reactor system to suppress the side oxidation reactions and improve the performance of the catalysts towards CH4 conversion and C2+yield.This review paper proposes employing a circulating reactor system coupled with catalyst fine particles but having little internal diffusion resistance to maximize one-pass C2+selectivity and yield of the OCM reaction and evaluate its industrial application potential. 展开更多
关键词 Oxidative coupling of methane METHANE C2+ ETHYLENE OCM Reactor
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Serum N-terminal DDR1:A Novel Diagnostic Marker of Liver Fibrosis Severity 被引量:1
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作者 Yuxin zhang Yujie zhang +5 位作者 Huifang Liang Zeng Zhuo Pan Fan Yifa Chen zhanguo zhang Wanguang zhang 《Journal of Clinical and Translational Hepatology》 SCIE 2021年第5期702-710,共9页
Background and Aims:The expression of discoidin domain receptor 1(DDR1)is commonly up-regulated and undergoes collagen-induced ectodomain(N-terminal)shedding during the progression of liver fibrosis.This study aimed t... Background and Aims:The expression of discoidin domain receptor 1(DDR1)is commonly up-regulated and undergoes collagen-induced ectodomain(N-terminal)shedding during the progression of liver fibrosis.This study aimed to evaluate the clinical utility of N-terminal DDR1 as a diagnostic biomarker for liver fibrosis.Methods:N-terminal DDR1 shedding was evaluated using cell lines,liver fibrosis mouse models,clinical data of 298 patients collected from February 2019 to June 2020.The clinical data were divided into test and validation cohorts to evaluate the diagnostic performance of serum N-terminal DDR1.Results:Timeand dosage-dependent N-terminal DDR1 shedding stimulated by collagen I was observed in a hepatocyte cell line model.The type I collagen deposition and serum N-terminal DDR1 levels concurrently increased in the development of liver fibrosis in mouse models.Clinical data demonstrated a significant diagnostic power of serum N-terminal DDR1 levels as an accurate biomarker of liver fibrosis and cirrhosis.The diagnostic performance was further increased when applying N-DDR1/albumin ratio,achieving area under the curve of 0.790,0.802,0.879,and 0.865 for detecting histological fibrosis stages F≥2,F≥3,F 4 with liver biopsy as a reference method,and cirrhosis according to imaging techniques,respectively.With a cut-off of 55.6,a sensitivity,specificity,positive predictive value,and negative predictive value of 82.7%,76.6%,67.4%,and 88.3%were achieved for the detection of cirrhosis.Conclusions:Serum N-terminal DDR1 appears to be a novel diagnostic marker for liver fibrosis. 展开更多
关键词 DDR1 SERUM DOSAGE
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Preparation and Characterization of Ultra-thin Pd-Ag Alloy Membranes
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作者 Renguo SONG zhanguo zhang +2 位作者 Chao WANG Hai LI Zhixiu WANG 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2013年第4期361-365,共5页
Ultra-thin Pd-Ag alloy membranes were prepared initially by cold rolling, and it was found that there exist a large number of defects such as pinholes or cracks in the as-rolled membranes. Subsequently, these defects ... Ultra-thin Pd-Ag alloy membranes were prepared initially by cold rolling, and it was found that there exist a large number of defects such as pinholes or cracks in the as-rolled membranes. Subsequently, these defects were repaired using electroless plating technique. The morphologies of the membranes have been examined by scanning electron microscopy (SEM). It was observed in some as-repaired membranes that the defects were disappeared. A hydrogen permeation study has demonstrated that the as-repaired Pd-Ag alloy membranes were of high hydrogen permeation flux and hydrogen selectivity. 展开更多
关键词 Pd-Ag alloy membrane Cold rolling Electroless plating Hydrogen permeation
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