Juvenile hormone(JH)is one of the most important hormones in insects since it is essential for insect development.The mechanism by which JH affects the central nervous system still remains a mystery.In this study,we d...Juvenile hormone(JH)is one of the most important hormones in insects since it is essential for insect development.The mechanism by which JH affects the central nervous system still remains a mystery.In this study,we demonstrate that one of the JH receptors,Methoprene-tolerant(Met),is important for the control of neurite development and sleep behavior in Drosophila.With the identification of Met-expressing glial cells,the mechanism that Met negatively controls the mushroom body(MB)b lobes fusion and positively maintains pigment-dispersing factor s LNvs projection pruning has been established.Furthermore,despite the developmental effects,Met can also maintain nighttime sleep in a developmentindependent manner through the a/b lobe of MB.Combining analyses of neuronal morphology and entomological behavior,this study advances our understanding of how the JH receptor regulates the nervous system.展开更多
It is well established that pheromones are used by insects to transmit infor-mation between individuals.However,research has revealed that individual insects can be both the sender and the receiver of some pheromonal ...It is well established that pheromones are used by insects to transmit infor-mation between individuals.However,research has revealed that individual insects can be both the sender and the receiver of some pheromonal signals.It is therefore interesting to consider whether the pheromonal state of an individual insect can exert an effect on itself.In this study,we monitored the sleep activity of single flies exhibiting a mutation that leads to pheromonal deficiency and found that cuticular hydrocarbons(CHs)exerted self-regulatory effects on the amount of sleep experienced by these flies.To identify the physiological significance of this mechanism,we compared the amounts of sleep in in-dividual young flies and individual old flies(flies are known to sleep less as they get older)and compared this data with young and old flies exhibiting mutations that lead to CH reception defects.The differences in the amount of sleep experienced by young and old mutant flies were significantly lower than those of the control flies.Our data show that hydrocarbon signals produced by the cuticle in Drosophila can be self-perceived and regulate the amount of sleep acquired in a maturation-dependent manner.展开更多
基金supported by the National Natural Science Foundation of China Grants 31970458 and 31730076(to Z.W.Zhao)。
文摘Juvenile hormone(JH)is one of the most important hormones in insects since it is essential for insect development.The mechanism by which JH affects the central nervous system still remains a mystery.In this study,we demonstrate that one of the JH receptors,Methoprene-tolerant(Met),is important for the control of neurite development and sleep behavior in Drosophila.With the identification of Met-expressing glial cells,the mechanism that Met negatively controls the mushroom body(MB)b lobes fusion and positively maintains pigment-dispersing factor s LNvs projection pruning has been established.Furthermore,despite the developmental effects,Met can also maintain nighttime sleep in a developmentindependent manner through the a/b lobe of MB.Combining analyses of neuronal morphology and entomological behavior,this study advances our understanding of how the JH receptor regulates the nervous system.
基金supported by the National Natural Science Foundation of China(grant number 31772535)Juan Du by the National Natural Science Foundation of China(grant number 31572317)to Zhangwu Zhao.
文摘It is well established that pheromones are used by insects to transmit infor-mation between individuals.However,research has revealed that individual insects can be both the sender and the receiver of some pheromonal signals.It is therefore interesting to consider whether the pheromonal state of an individual insect can exert an effect on itself.In this study,we monitored the sleep activity of single flies exhibiting a mutation that leads to pheromonal deficiency and found that cuticular hydrocarbons(CHs)exerted self-regulatory effects on the amount of sleep experienced by these flies.To identify the physiological significance of this mechanism,we compared the amounts of sleep in in-dividual young flies and individual old flies(flies are known to sleep less as they get older)and compared this data with young and old flies exhibiting mutations that lead to CH reception defects.The differences in the amount of sleep experienced by young and old mutant flies were significantly lower than those of the control flies.Our data show that hydrocarbon signals produced by the cuticle in Drosophila can be self-perceived and regulate the amount of sleep acquired in a maturation-dependent manner.
