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A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis 被引量:7
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作者 zhanwen cheng Xiaoxing Liang +2 位作者 Shaojun Liang Nuoya Yin Francesco Faiola 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2020年第1期194-204,共11页
Air pollution has been linked to many health issues,including skin conditions,especially in children.Among all the atmospheric pollutants,ultrafine particles have been deemed very dangerous since they can readily pene... Air pollution has been linked to many health issues,including skin conditions,especially in children.Among all the atmospheric pollutants,ultrafine particles have been deemed very dangerous since they can readily penetrate the lungs and skin,and be absorbed into the bloodstream.Here,we employed a human embryonic stem cell(h ESC)-based differentiation system towards keratinocytes,to test the effects of ultrafine carbon particles,which mimic ambient ultrafine particles,at environment related concentrations.We found that10 ng/mL to 10μg/mL ultrafine carbon particles down-regulated the expression of the pluripotency marker SOX2 in h ESCs.Moreover,1μg/mL to 10μg/mL carbon particle treatments disrupted the keratinocyte differentiation,and up-regulated inflammationand psoriasis-related genes,such as IL-1β,IL-6,CXCL1,CXCL2,CXCL3,CCL20,CXCL8,and S100 A7 and S100 A9,respectively.Overall,our results provide a new insight into the potential developmental toxicity of atmospheric ultrafine particles. 展开更多
关键词 Human embryonic stem cells(hESCs) KERATINOCYTES Ultrafine carbon particles Inflammation PSORIASIS Developmental toxicity
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干细胞毒理学在大气污染健康风险评估中的应用 被引量:1
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作者 程战文 殷诺雅 Francesco Faiola 《中国科学:化学》 CAS CSCD 北大核心 2018年第10期1269-1279,共11页
随着雾霾天气的频繁出现,大气污染问题已引起全社会的高度关注.流行病学研究证实,大气污染物对人体特别是婴幼儿健康可产生巨大影响.其中,持久性有毒污染物的健康危害不容忽视,但因其在大气中含量较低,常规的毒理学模型较难准确反映其... 随着雾霾天气的频繁出现,大气污染问题已引起全社会的高度关注.流行病学研究证实,大气污染物对人体特别是婴幼儿健康可产生巨大影响.其中,持久性有毒污染物的健康危害不容忽视,但因其在大气中含量较低,常规的毒理学模型较难准确反映其毒性效应.本文从健康风险的角度出发,综述了目前干细胞毒理学在评价大气中持久性有毒污染物毒性效应时的应用,重点关注早期胚胎发育、心血管系统发育及神经系统发育过程中可能存在的健康风险及相关致毒机制.干细胞毒理学模型未来可发展为较全面的健康风险评估系统,用以深入且多角度阐释大气污染物的健康风险效应,尤其是在婴幼儿成长发育、多种器官系统机能评估等过程中起到关键作用. 展开更多
关键词 干细胞毒理学 大气污染 胚胎干细胞 发育毒性
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Metagenomic and viromic data mining reveals viral threats in biologically treated domestic wastewater 被引量:1
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作者 Xiang Li zhanwen cheng +3 位作者 Chenyuan Dang Miao Zhang Yan Zheng Yu Xia 《Environmental Science and Ecotechnology》 2021年第3期1-8,共8页
Activated sludge(AS),a common biological secondary treatment process in wastewater treatment plants(WWTPs),is known to remove a large spectrum of microorganisms.Yet little is known about its effect on the entire viral... Activated sludge(AS),a common biological secondary treatment process in wastewater treatment plants(WWTPs),is known to remove a large spectrum of microorganisms.Yet little is known about its effect on the entire viral community.After compiling 3 Tbp of next-generation sequencing(NGS)metagenomic/viromic datasets consisted of 119 sub-datasets of influent,effluent,and AS samples from 27WWTPs,viral removal efficacy is evaluated through data mining.The normalized abundance of viruses suggests effluents exhibit the highest viral prevalence(3.21±3.26%,n=13)followed by the AS(0.48±0.25%,n=57)and influents(0.23±0.17%,n=17).In contrast,plasmids,representing genetic element of bacteria,show higher average prevalence(0.73±0.82%,n=17)in influents than those of the AS(0.63±0.26%,n=57)and effluents(0.35±0.42%,n=13).Furthermore,the abundance-occupancy analysis identifies 142 core phage viruses and 17 non-phages core viruses,including several pathogenic viruses in the AS virome.The persistent occurrence of pathogenic viruses,coupled with nonfavorable virus removal by the AS treatment,reveals the hidden virus threats in biologically treated domestic wastewater.The mechanisms for why viruses persist and the possibility that WWTPs are potential hotspots for viral survival deserve attention. 展开更多
关键词 WWTP METAGENOMIC Viromic Virus Data mining Biologically treated wastewater
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