Crop straw has huge resource potential. It has an important significance for realizing waste recycling and improving eco-environment to prefect straw marketization system and sufficiently stimulate farmers’ straw mar...Crop straw has huge resource potential. It has an important significance for realizing waste recycling and improving eco-environment to prefect straw marketization system and sufficiently stimulate farmers’ straw marketization behavior. Based on 427 copies of investigation data on farmers,influence mechanism framework of farmers’ straw marketization behavior is constructed,and key factors of farmers’ straw marketization behavior are analyzed. Results show that farmers joining in straw marketization account for 42. 1%; in influence factors of farmers’ straw marketization behavior,cultivated land area,market price level,logistics satisfaction and air quality perception have significantly positive impacts on farmers’ straw marketization behavior,while education degree,agricultural income proportion and traffic convenience have significantly negative impacts on farmers’ straw marketization behavior. Therefore,it needs strengthening propaganda intensity,carrying out reasonable subsidies and support,encouraging and breeding new type of organization,and establishing and improving the price mechanism of straw marketization to perfect straw marketization construction.展开更多
Objective To assess the accuracy of preoperative serum CA19-9 levels in predicting the resectability of pancreatic adenocarcinoma.Methods Patients with biopsy-proven pancreatic adenocarcinoma who had preoperative seru...Objective To assess the accuracy of preoperative serum CA19-9 levels in predicting the resectability of pancreatic adenocarcinoma.Methods Patients with biopsy-proven pancreatic adenocarcinoma who had preoperative serum CA19-9 level data were enrolled in the present retrospective analysis. Receiver operating characteristics(ROC) curve analysis was used to determine the optimal cut-off value of CA19-9. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated at this cut-off point.Results Seventy-six patients with pancreatic adenocarcinoma that was considered potentially resectable according to radiological imaging were included. Of all 76 patients, 44 received complete resection of the pancreatic adenocarcinoma. The preoperative serum CA19-9 level was significantly higher in the unresectable tumor group than in the resectable tumor group(P = 0.0036). The area under the ROC curve was 0.749(95% confidence interval [CI]: 0.637–0.842). When the cut-off value of CA19-9 was set to 359.1 U/m L, the sensitivity, specificity, positive and negative predictive values were 71.9%(95% CI: 53.3%–86.3%), 70.5%(95% CI: 54.8%–83.2%), 63.9%(95% CI: 46.0%–79.4%), and 77.5%(95% CI: 61.5%–89.2%), respectively.Conclusion The preoperative serum CA19-9 level is useful for predicting the resectability of pancreatic adenocarcinoma.展开更多
Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, ...Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.展开更多
Nano-drug delivery systems(nanoDDS)have been extensively investigated clinically to improve the therapeutic effect of anticancer drugs.However,the complicated synthesis during the preparation as well as the potential ...Nano-drug delivery systems(nanoDDS)have been extensively investigated clinically to improve the therapeutic effect of anticancer drugs.However,the complicated synthesis during the preparation as well as the potential drug leakage during transportation has greatly limited their general application.In this work,a calixarene-integrated nanoDDS(CanD)that achieves tumor-targeted delivery and tracking of anti-cancer drugs in vivo is presented.The hypoxia-responsive calixarene(SAC4A)exhibits high binding affinity to a series of anti-cancer drugs and rhodamine B(RhB)under normoxic condition while decreasing the binding affinity under hypoxic condition,which leads to the drug release and fluorescence recovery simultaneously.Furthermore,the hypoxia-responsiveness of SAC4A conveys CanD with tumor-targeting ability,resulting in the enrichment of the drug in tumors and enhancement in tumor suppression in mice.Moreover,CanD could become a general platform allowing the delivery of a wide scope of anti-cancer drugs that have strong host-guest interaction with SAC4A.展开更多
The accumulation of solubleβ-amyloid aggregates(sAβs)is one of the main culprits in Alzheimer’s disease(AD)progression,which can lead to synaptic dysfunction and subsequent neurodegeneration.Herein,we describe a na...The accumulation of solubleβ-amyloid aggregates(sAβs)is one of the main culprits in Alzheimer’s disease(AD)progression,which can lead to synaptic dysfunction and subsequent neurodegeneration.Herein,we describe a nanoscavenger with novel structure that can cross the blood–brain barrier(BBB),accurately collect neurotoxic sAβs,and facilitate amounts ofβ-amyloid(Aβ)clearance.展开更多
文摘Crop straw has huge resource potential. It has an important significance for realizing waste recycling and improving eco-environment to prefect straw marketization system and sufficiently stimulate farmers’ straw marketization behavior. Based on 427 copies of investigation data on farmers,influence mechanism framework of farmers’ straw marketization behavior is constructed,and key factors of farmers’ straw marketization behavior are analyzed. Results show that farmers joining in straw marketization account for 42. 1%; in influence factors of farmers’ straw marketization behavior,cultivated land area,market price level,logistics satisfaction and air quality perception have significantly positive impacts on farmers’ straw marketization behavior,while education degree,agricultural income proportion and traffic convenience have significantly negative impacts on farmers’ straw marketization behavior. Therefore,it needs strengthening propaganda intensity,carrying out reasonable subsidies and support,encouraging and breeding new type of organization,and establishing and improving the price mechanism of straw marketization to perfect straw marketization construction.
文摘Objective To assess the accuracy of preoperative serum CA19-9 levels in predicting the resectability of pancreatic adenocarcinoma.Methods Patients with biopsy-proven pancreatic adenocarcinoma who had preoperative serum CA19-9 level data were enrolled in the present retrospective analysis. Receiver operating characteristics(ROC) curve analysis was used to determine the optimal cut-off value of CA19-9. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated at this cut-off point.Results Seventy-six patients with pancreatic adenocarcinoma that was considered potentially resectable according to radiological imaging were included. Of all 76 patients, 44 received complete resection of the pancreatic adenocarcinoma. The preoperative serum CA19-9 level was significantly higher in the unresectable tumor group than in the resectable tumor group(P = 0.0036). The area under the ROC curve was 0.749(95% confidence interval [CI]: 0.637–0.842). When the cut-off value of CA19-9 was set to 359.1 U/m L, the sensitivity, specificity, positive and negative predictive values were 71.9%(95% CI: 53.3%–86.3%), 70.5%(95% CI: 54.8%–83.2%), 63.9%(95% CI: 46.0%–79.4%), and 77.5%(95% CI: 61.5%–89.2%), respectively.Conclusion The preoperative serum CA19-9 level is useful for predicting the resectability of pancreatic adenocarcinoma.
基金supported by the National Natural Science Foundation of China (52073218, 22135005, 51873162, 51933006,51988102, 52122310, 22075050, 51833008, 51733006, 51733001,52122304)Jiangsu Province Science Foundation for Youths(BK20200241)+3 种基金Science and Technology Commission of Shanghai Municipality (20JC1414902, 21511104900)Shanghai Municipal Education Commission (2017-01-07-00-07-E00062)the National Key Research and Development Program (2021YFA1201200) of Chinathe Zhejiang Provincial Key Research and Development Program (2020C01123)。
文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.
基金National Key Research and Development Programs of China(No.2018YFA0209700)National Natural Science Foundation of China(NSFC,No.22077073)+1 种基金Frontiers Science Center for New Organic Matter(No.63181206)Fundamental Research Funds for the Central Universities(Nankai University,No.63206015).
文摘Nano-drug delivery systems(nanoDDS)have been extensively investigated clinically to improve the therapeutic effect of anticancer drugs.However,the complicated synthesis during the preparation as well as the potential drug leakage during transportation has greatly limited their general application.In this work,a calixarene-integrated nanoDDS(CanD)that achieves tumor-targeted delivery and tracking of anti-cancer drugs in vivo is presented.The hypoxia-responsive calixarene(SAC4A)exhibits high binding affinity to a series of anti-cancer drugs and rhodamine B(RhB)under normoxic condition while decreasing the binding affinity under hypoxic condition,which leads to the drug release and fluorescence recovery simultaneously.Furthermore,the hypoxia-responsiveness of SAC4A conveys CanD with tumor-targeting ability,resulting in the enrichment of the drug in tumors and enhancement in tumor suppression in mice.Moreover,CanD could become a general platform allowing the delivery of a wide scope of anti-cancer drugs that have strong host-guest interaction with SAC4A.
基金supported by the National Key Research and Development Programs of China(grant no.2018YFA0209700)the National Natural Science Foundation of China(NSFC+4 种基金grant nos.51673100 and 21620102005)the Fundamental Research Funds for the Central Universities(Nankai Universitygrant nos.ZB19100123 and ZB16008705)the Tianjin Natural Science Foundation(grant no.18JCQNJC03600)the China Postdoctoral Science Foundation(grant no.2019M660975).
文摘The accumulation of solubleβ-amyloid aggregates(sAβs)is one of the main culprits in Alzheimer’s disease(AD)progression,which can lead to synaptic dysfunction and subsequent neurodegeneration.Herein,we describe a nanoscavenger with novel structure that can cross the blood–brain barrier(BBB),accurately collect neurotoxic sAβs,and facilitate amounts ofβ-amyloid(Aβ)clearance.
