Objective:To study the effect of adjuvant nicorandil therapy on inflammation, plaque stability and platelet function in patients with unstable angina.Methods:A total of 134 patients with unstable angina who received d...Objective:To study the effect of adjuvant nicorandil therapy on inflammation, plaque stability and platelet function in patients with unstable angina.Methods:A total of 134 patients with unstable angina who received drug therapy in our hospital between March 2015 and March 2016 were selected as the research subjects and randomly divided into the experimental group who accepted nicorandil combined with conventional therapy and the control group who accepted conventional therapy. 2 weeks after treatment, serum inflammation indexes and plaque stability indexes as well as peripheral blood platelet function parameters were determined.Results:2 weeks after treatment, serum hs-CRP, TNF-α, IL-18, IL-23, MMP1, MMP2, MMP3, MMP9 and ICTP levels of experimental group were significantly lower than those of control group;peripheral blood CD63, PAC-1, CD42b and GP-VI fluorescence intensity as well as Angle, MA and CI levels of experimental group were significantly lower than those of control group while R and K levels were significantly higher than those of control group.Conclusion:Adjuvant nicorandil therapy can relieve the inflammatory response in patients with unstable angina, and thereby inhibit the inflammation-mediated fibrous cap degradation, plaque stability decrease, platelet activation and thrombosis.展开更多
文摘Objective:To study the effect of adjuvant nicorandil therapy on inflammation, plaque stability and platelet function in patients with unstable angina.Methods:A total of 134 patients with unstable angina who received drug therapy in our hospital between March 2015 and March 2016 were selected as the research subjects and randomly divided into the experimental group who accepted nicorandil combined with conventional therapy and the control group who accepted conventional therapy. 2 weeks after treatment, serum inflammation indexes and plaque stability indexes as well as peripheral blood platelet function parameters were determined.Results:2 weeks after treatment, serum hs-CRP, TNF-α, IL-18, IL-23, MMP1, MMP2, MMP3, MMP9 and ICTP levels of experimental group were significantly lower than those of control group;peripheral blood CD63, PAC-1, CD42b and GP-VI fluorescence intensity as well as Angle, MA and CI levels of experimental group were significantly lower than those of control group while R and K levels were significantly higher than those of control group.Conclusion:Adjuvant nicorandil therapy can relieve the inflammatory response in patients with unstable angina, and thereby inhibit the inflammation-mediated fibrous cap degradation, plaque stability decrease, platelet activation and thrombosis.
