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Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice 被引量:5
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作者 zhao-xiu liu Wei-Jie Chen +11 位作者 Yang Wang Bing-Qian Chen Yi-Cun liu Tiao-Chun Cheng Lei-Lei Luo Lin Chen Lin-Ling Ju Yuan liu Ming Li Nan Feng Jian-Guo Shao Zhao-Lian Bian 《World Journal of Gastroenterology》 SCIE CAS 2022年第47期6752-6768,共17页
BACKGROUND Although expression of interleukin(IL)-34 is upregulated in active ulcerative colitis(UC),the molecular function and underlying mechanism are largely unclear.AIM To investigate the function of IL-34 in acut... BACKGROUND Although expression of interleukin(IL)-34 is upregulated in active ulcerative colitis(UC),the molecular function and underlying mechanism are largely unclear.AIM To investigate the function of IL-34 in acute colitis,in a wound healing model and in colitis-associated cancer in IL-34-deficient mice.METHODS Colitis was induced by administration of dextran sodium sulfate(DSS),and carcinogenesis was induced by azoxymethane(AOM).Whether the impact of IL-34 on colitis was dependent on macrophages was validated by depletion of macrophages in a murine model.The association between IL-34 expression and epithelial proliferation was studied in patients with active UC.RESULTS IL-34 deficiency aggravated murine colitis in acute colitis and in wound healing phase.The effect of IL-34 on experimental colitis was not dependent on macrophage differentiation and polarization.IL-34-deficient mice developed more tumors than wild-type mice following administration of AOM and DSS.No significant difference was shown in degree of cellular differentiation in tumors between wild-type and IL-34-deficient mice.IL-34 was dramatically increased in the active UC patients as previously reported.More importantly,expression of IL-34 was positively correlated with epithelial cell proliferation in patients with UC.CONCLUSION IL-34 deficiency exacerbates colonic inflammation and accelerates colitis-associated carcinogenesis in mice.It might be served as a potential therapeutic target in UC. 展开更多
关键词 Interleukin-34 Ulcerative colitis Mucosal healing Colitis-associated cancer Macrophage Murine model
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