NRS2002 assesses nutritional status of leukemia patients undergoing hematopoietic stem cell transplantation

Objective： To discuss whether nutritional risk screening 2002 （NRS2002） is appropriate for nutritional risk screening for leukemia patients before and after hematopoietic stem cell transplantation （HSCT）, and whether there are risk differences in other conditions, such as age, gender and matching degree; to find the methods and indicators of nutritional risk screening for these patients before and after HSCT, in order to give timely intervention to guarantee the successful completion of the entire transplantation process. Methods： Nutritional risk of 99 leukemia patients was screened with NRS2002 before and after HSCT. The ^（2 test was applied to compare the risk differences between groups such as age, gender and matching degree, while the differences of other enumeration data, such as recent （1-3 months） weight loss, reduced food intake within one week and BMI, were compared by continuity correction. Results： Of the 99 leukemia patients, 22 cases （22.2 %） had nutritional risk before HSCT, while all patients had nutritional risk after ttSCT; there is no significant difference in nutritional risk between male and female, and patients of less than 30 years old, not-full matched, recent （1-3 months） weight loss, reduced food intake within a week or BMI 〈18.5 were more likely to have nutritional risk; and 77 cases （77.8%） had weight loss, among which 49 patients （63.6%） had more than 5% weight loss within one month. Conclusions= This study showed that leukemia patients should receive the nutritional risk screening conventionally before and after HSCT, and NRS2002 was only appropriate for nutritional risk screening before HSCT. More attention should be paid to the patients less than 30 years old or not-full matched. Weight change was one of the important nutritional indicators for patients after HSCT.

Major Miocene geological events in southern Tibet and eastern Asia induced by the subduction of the Ninetyeast Ridge

Cenozoic adakitic rocks in the Gangdese changed from barren continental melts to ore-forming slab melts at * 23 Ma. The distribution and chemical characteristics of the ore-forming adakites point to an association with the Ninetyeast Ridge. The subduction of the thick,rigid Ninetyeast Ridge changed the geometry and rheology of the eastern Tibetan Plateau lithosphere and asthenosphere, restrained the eastward escape of asthenospheric mantle as well as continental fragments, and promoted the uplift and building of the Tibetan Plateau, which consequently changed the tectonic and climatic regimes in eastern Asia.

Association between polymorphisms of prokineticin receptor(PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss

Recurrent pregnancy loss （RPL） is a condition with complex etiologies, to which both genetic and envi- ronmental factors may contribute. During the last decade, studies indicated that the expression patterns of the pro- kineticin receptor （PKR1 and PKR2） are closely related to early pregnancy. However, there are few studies on the role of PKR1 and PKR2 in RPL. In this study, we purpose to investigate the association between polymorphisms of the prokineticin receptor （PKR1 rs4627609 and PKR2 rs6053283） and RPL on a group of 93 RPL cases and 169 healthy controls. Genotyping of the single nucleotide polymorphisms （SNPs） was performed using a Sequenom MassARRAY iPLEX system. The results revealed a significant association between PKR2 rs6053283 polymorphism and RPL （P=0.003）, whereas no association was observed between PKR1 rs4627609 polymorphism and RPL （P=-0.929） in the Chinese Han population.