Triple-negative breast cancer(TNBC)has a poor prognosis because of its aggressive characteristics and lack of targeted therapies.1 Recently,it has been reported that TNBC is sensitiveto ferroptosis,an iron-dependent t...Triple-negative breast cancer(TNBC)has a poor prognosis because of its aggressive characteristics and lack of targeted therapies.1 Recently,it has been reported that TNBC is sensitiveto ferroptosis,an iron-dependent type of programmed cell death,making it a potential target for the treatment of TNBC.2 Breast cancer stem cells(BCSCs),a small population of cancer cells that possess the infinite proliferative potential and tumor-initiating properties,play important roles in drug resistance.3 The responses of BCsCs to ferroptosis-inducing agents are controversial and remain elusive.展开更多
基金supported by the Natural Science Foundation of Shandong Province,China(No.ZR2021YQ50,Excellent Young Scholars Program)National Natural Science Foundation of China(No.82003227)+3 种基金China Postdoctoral Science Foundation(No.2019M663516 and 2021T140487)Post-Doctor Research Project,Sichuan University,China(No.2020SCU12021)Post-Doctor Research Project,West China Hospital,Sichuan University,China(No.2018HXBH067)Sichuan Provincial Research Foundation for Basic Research(China)(No.2020YFS0272).
文摘Triple-negative breast cancer(TNBC)has a poor prognosis because of its aggressive characteristics and lack of targeted therapies.1 Recently,it has been reported that TNBC is sensitiveto ferroptosis,an iron-dependent type of programmed cell death,making it a potential target for the treatment of TNBC.2 Breast cancer stem cells(BCSCs),a small population of cancer cells that possess the infinite proliferative potential and tumor-initiating properties,play important roles in drug resistance.3 The responses of BCsCs to ferroptosis-inducing agents are controversial and remain elusive.
