Dear Editor,Rheumatoid arthritis(RA),which is the most common inflammatory arthritis disease,as well as a kind of most prevalent autoimmune disease,affects 1–3%population all over the world.1 Currently available trea...Dear Editor,Rheumatoid arthritis(RA),which is the most common inflammatory arthritis disease,as well as a kind of most prevalent autoimmune disease,affects 1–3%population all over the world.1 Currently available treatments can reduce the disability rate of patients with RA to some extent,but they cannot completely block the inflammatory joint destruction and relieve the pain that comes with it.Our previous study found that Neuron Navigator 2(NAV2)increased significantly in RA and was regulated by transcription factor E2F1.2 However,it is still unclear why NAV2 is elevated at the genetic level in RA fibroblast-like synoviocytes(FLS).Additionally,RA’s exact pathological mechanisms and therapeutic targets are also not fully understood.Hence,an indepth study of the pathogenesis of RA is urgently needed.展开更多
Backgroud:The outbreak of COVID-19 has brought unprecedented perils to human health and raised public health concerns in more than two hundred countries.Safe and effective treatment scheme is needed urgently.Objective...Backgroud:The outbreak of COVID-19 has brought unprecedented perils to human health and raised public health concerns in more than two hundred countries.Safe and effective treatment scheme is needed urgently.Objective:To evaluate the effects of integratedTCM and western medicine treatment scheme on COVID-19.Methods:A single-armed clinical trial was carried out in Hangzhou Xixi Hospital,an affiliated hospital with Zhejiang Chinese Medical University.102 confirmed cases were screened out from 725 suspected cases and 93 of them were treated with integrated TCM and western medicine treatment scheme.Results:83 cases were cured,5 cases deteriorated,and 5 cases withdrew from the study.No deaths were reported.The mean relief time of fever,cough,diarrhea,and fatigue were(4.78±4.61)days,(7.22±4.99)days,(5.28±3.39)days,and(5.28±3.39)days,respectively.It took(14.84±5.50)days for SARS-CoV-2 by nucleic acid amplification-based testing to turn negative.Multivariable cox regression analysis revealed that age,BMI,PISCT,BPC,AST,CK,BS,and UPRO were independent risk factors for COVID-19 treatment.Conclusion:Our study suggested that integrated TCM and western medicine treatment scheme was effective for COVID-19.展开更多
Optical devices are highly attractive for biosensing as they can not only enable quantitative measurements of analytes but also provide information on molecular structures.Unfortunately,typical refractive index-based ...Optical devices are highly attractive for biosensing as they can not only enable quantitative measurements of analytes but also provide information on molecular structures.Unfortunately,typical refractive index-based optical sensors do not have sufficient sensitivity to probe the binding of low-molecular-weight analytes.Non-optical devices such as field-effect transistors can be more sensitive but do not offer some of the significant features of optical devices,particularly molecular fingerprinting.We present optical conductivity-based mid-infrared(mid-IR)biosensors that allow for sensitive and quantitative measurements of low-molecular-weight analytes as well as the enhancement of spectral fingerprints.The sensors employ a hybrid metasurface consisting of monolayer graphene and metallic nano-antennas and combine individual advantages of plasmonic,electronic and spectroscopic approaches.First,the hybrid metasurface sensors can optically detect target molecule-induced carrier doping to graphene,allowing highly sensitive detection of low-molecular-weight analytes despite their small sizes.Second,the resonance shifts caused by changes in graphene optical conductivity is a well-defined function of graphene carrier density,thereby allowing for quantification of the binding of molecules.Third,the sensor performance is highly stable and consistent thanks to its insensitivity to graphene carrier mobility degradation.Finally,the sensors can also act as substrates for surfaceenhanced infrared spectroscopy.We demonstrated the measurement of monolayers of sub-nanometer-sized molecules or particles and affinity binding-based quantitative detection of glucose down to 200 pM(36 pg/mL).We also demonstrated enhanced fingerprinting of minute quantities of glucose and polymer molecules.展开更多
In the evaluation of graduation theses,teachers’evaluation criteria for graduation theses are inconsistent,subjective and not completely reasonable and fair.This paper proposes using the BERT model to analyze the exi...In the evaluation of graduation theses,teachers’evaluation criteria for graduation theses are inconsistent,subjective and not completely reasonable and fair.This paper proposes using the BERT model to analyze the existing graduation papers in colleges and universities and make quantitatively evaluate students’graduation projects according to the given relevant parameters.The purpose of this method is to use standards to make comprehensive,systematic and accurate evaluations and avoid the phenomenon of high repetition and similarity caused by a large number of teachers’comments.This can not only effectively improve the efficiency of graduation design evaluation but also improve the fairness of evaluation.In this paper,changing the review work of the graduation thesis from pure manual operation to machine review combined with manual operation can not only reduce manpower consumption but also make the review work more objective and fair,making it more objective on the basis of traditional subjective review.展开更多
基金supported by grants from Macao Science and Technology Development Fund(FDCT)(0052/2020/A,0021/2020/AGJ,and 0011/2020/A1)The National Natural Science Foundation of China(No.81973320)The Key Technology R&D Program of Science and Technology Commission Foundation of Tianjin(20YFZCSY00460).
文摘Dear Editor,Rheumatoid arthritis(RA),which is the most common inflammatory arthritis disease,as well as a kind of most prevalent autoimmune disease,affects 1–3%population all over the world.1 Currently available treatments can reduce the disability rate of patients with RA to some extent,but they cannot completely block the inflammatory joint destruction and relieve the pain that comes with it.Our previous study found that Neuron Navigator 2(NAV2)increased significantly in RA and was regulated by transcription factor E2F1.2 However,it is still unclear why NAV2 is elevated at the genetic level in RA fibroblast-like synoviocytes(FLS).Additionally,RA’s exact pathological mechanisms and therapeutic targets are also not fully understood.Hence,an indepth study of the pathogenesis of RA is urgently needed.
基金This Research was Supported by Zhejiang Provincial Natural Science Foundation of China‘Emergency Prevention and Treatment of COVID-19′,Under Grated NO.LEZ20H190001 and COVID-19 prevention and control special scientific research project of Hangzhou Science and Tech-nology Bureau,China.
文摘Backgroud:The outbreak of COVID-19 has brought unprecedented perils to human health and raised public health concerns in more than two hundred countries.Safe and effective treatment scheme is needed urgently.Objective:To evaluate the effects of integratedTCM and western medicine treatment scheme on COVID-19.Methods:A single-armed clinical trial was carried out in Hangzhou Xixi Hospital,an affiliated hospital with Zhejiang Chinese Medical University.102 confirmed cases were screened out from 725 suspected cases and 93 of them were treated with integrated TCM and western medicine treatment scheme.Results:83 cases were cured,5 cases deteriorated,and 5 cases withdrew from the study.No deaths were reported.The mean relief time of fever,cough,diarrhea,and fatigue were(4.78±4.61)days,(7.22±4.99)days,(5.28±3.39)days,and(5.28±3.39)days,respectively.It took(14.84±5.50)days for SARS-CoV-2 by nucleic acid amplification-based testing to turn negative.Multivariable cox regression analysis revealed that age,BMI,PISCT,BPC,AST,CK,BS,and UPRO were independent risk factors for COVID-19 treatment.Conclusion:Our study suggested that integrated TCM and western medicine treatment scheme was effective for COVID-19.
基金supported by the National Science Foundation(grants no.ECCS-1509760 and ECCS-1307948)a Defense Advanced Research Projects Agency Young Faculty Award(grant no.D15AP00111)+1 种基金the Air Force Office of Scientific Research(grants no.FA9550–14–1–0389 and FA9550–16–1–0322)Research was carried out in part at the Center for Functional Nanomaterials,Brookhaven National Laboratory,which is supported by the US Department of Energy,Office of Basic Energy Sciences(contract no.DE-SC0012704).
文摘Optical devices are highly attractive for biosensing as they can not only enable quantitative measurements of analytes but also provide information on molecular structures.Unfortunately,typical refractive index-based optical sensors do not have sufficient sensitivity to probe the binding of low-molecular-weight analytes.Non-optical devices such as field-effect transistors can be more sensitive but do not offer some of the significant features of optical devices,particularly molecular fingerprinting.We present optical conductivity-based mid-infrared(mid-IR)biosensors that allow for sensitive and quantitative measurements of low-molecular-weight analytes as well as the enhancement of spectral fingerprints.The sensors employ a hybrid metasurface consisting of monolayer graphene and metallic nano-antennas and combine individual advantages of plasmonic,electronic and spectroscopic approaches.First,the hybrid metasurface sensors can optically detect target molecule-induced carrier doping to graphene,allowing highly sensitive detection of low-molecular-weight analytes despite their small sizes.Second,the resonance shifts caused by changes in graphene optical conductivity is a well-defined function of graphene carrier density,thereby allowing for quantification of the binding of molecules.Third,the sensor performance is highly stable and consistent thanks to its insensitivity to graphene carrier mobility degradation.Finally,the sensors can also act as substrates for surfaceenhanced infrared spectroscopy.We demonstrated the measurement of monolayers of sub-nanometer-sized molecules or particles and affinity binding-based quantitative detection of glucose down to 200 pM(36 pg/mL).We also demonstrated enhanced fingerprinting of minute quantities of glucose and polymer molecules.
基金supported by the scientific research project of Nanjing Xiaozhuang University (Project name:Graduation paper“Evaluation”--Evaluation Automatic generation system based on multilevel analysis,No.2020XSKY001)supported by the project (Project name:Research and development of self generating remote controller for intelligent toilet,No.2021320108001139)supported by the project (Project name:Modeling of energy industry based on artificial intelligence holographic interactive atlas system,No.2021320108002080).
文摘In the evaluation of graduation theses,teachers’evaluation criteria for graduation theses are inconsistent,subjective and not completely reasonable and fair.This paper proposes using the BERT model to analyze the existing graduation papers in colleges and universities and make quantitatively evaluate students’graduation projects according to the given relevant parameters.The purpose of this method is to use standards to make comprehensive,systematic and accurate evaluations and avoid the phenomenon of high repetition and similarity caused by a large number of teachers’comments.This can not only effectively improve the efficiency of graduation design evaluation but also improve the fairness of evaluation.In this paper,changing the review work of the graduation thesis from pure manual operation to machine review combined with manual operation can not only reduce manpower consumption but also make the review work more objective and fair,making it more objective on the basis of traditional subjective review.