This paper studies the reactive power and voltage coordinated control scheme. According to the characteristics of Hunan power grid, the coordinated schemes about Hunan power grid with Central China Power Grid, as well...This paper studies the reactive power and voltage coordinated control scheme. According to the characteristics of Hunan power grid, the coordinated schemes about Hunan power grid with Central China Power Grid, as well as Changsha power grid are proposed. At the same time, this paper builds a two-way interactive and multiple dispatching reactive power and voltage coordinated control mode, and can be successfully applied in Hunan power grid. The operation results show that this control scheme fulfills the ability of large power grids in optimal allocating of resources, effectively integrates the reactive power resources of the entire grid, achieves the purpose of reducing power grid loss, improving voltage quality, reducing the operating numbers of the reactive power equipment.展开更多
The electrocatalytic nitrate reduction reaction(NitRR)represents a promising approach toward achieving economically and environmentally sustainable ammonia.However,it remains a challenge to regulate the size effect of...The electrocatalytic nitrate reduction reaction(NitRR)represents a promising approach toward achieving economically and environmentally sustainable ammonia.However,it remains a challenge to regulate the size effect of electrocatalysts to optimize the catalytic activity and ammonia selectivity.Herein,the Cu-based catalysts were tailored at the atomic level to exhibit a size gradient ranging from single-atom catalysts(SACs,0.15–0.35 nm)to single-cluster catalysts(SCCs,1.0–2.8 nm)and nanoparticles(NPs,20–30 nm),with the aim of studying the size effect for the NO_(3)^(-)-to-NH_(3) reduction reaction.Especially,the Cu SCCs exhibit enhanced metal–substrate and metal–metal interactions by taking advantageous features of Cu SACs and Cu NPs.Thus,Cu SCCs achieve exceptional electrocatalytic performance for the NitRR with a maximum Faradaic efficiency of ca.96%NH_(3)and the largest yield rate of ca.1.99 mg·h^(-1)·cm^(-2) at-0.5 V vs.reversible hydrogen electrode(RHE).The theoretical calculation further reveals the size effect and coordination environment on the high catalytic activity and selectivity for the NitRR.This work provides a promising various size-controlled design strategy for aerogel-based catalysts effectively applied in various electrocatalytic reactions.展开更多
After decades of development,protein and peptide drugs have now grown into a major drug class in the marketplace.Target identification and validation are crucial for the discovery of protein and peptide drugs,and bioi...After decades of development,protein and peptide drugs have now grown into a major drug class in the marketplace.Target identification and validation are crucial for the discovery of protein and peptide drugs,and bioinformatics prediction of targets based on the characteristics of known target proteins will help improve the efficiency and success rate of target selection.However,owing to the developmental history in the pharmaceutical industry,previous systematic exploration of the target spaces has mainly focused on traditional small-molecule drugs,while studies related to protein and peptide drugs are lacking.Here,we systematically explore the target spaces in the human genome specifically for protein and peptide drugs.Compared with other proteins,both successful protein and peptide drug targets have many special characteristics,and are also significantly different from those of small-molecule drugs in many aspects.Based on these features,we develop separate effective genome-wide target prediction models for protein and peptide drugs.Finally,a user-friendly web server,Predictor Of Protein and Pept Ide drugs’therapeutic Targets(POPPIT)(http://poppit.ncpsb.org.cn/),is established,which provides not only target prediction specifically for protein and peptide drugs but also abundant annotations for predicted targets.展开更多
文摘This paper studies the reactive power and voltage coordinated control scheme. According to the characteristics of Hunan power grid, the coordinated schemes about Hunan power grid with Central China Power Grid, as well as Changsha power grid are proposed. At the same time, this paper builds a two-way interactive and multiple dispatching reactive power and voltage coordinated control mode, and can be successfully applied in Hunan power grid. The operation results show that this control scheme fulfills the ability of large power grids in optimal allocating of resources, effectively integrates the reactive power resources of the entire grid, achieves the purpose of reducing power grid loss, improving voltage quality, reducing the operating numbers of the reactive power equipment.
基金support from the National Nature Science Foundation of China(No.52202372)the Sichuan Science and Technology Program(Nos.2023NSFSC0436 and 2023NSFSC0089)+1 种基金the Fundamental Research Funds for the Central Universities(Nos.YJ2021151 and 20826041G4185)T.T.G.acknowledges the Chengdu University new faculty start-up funding(No.2081920074).
文摘The electrocatalytic nitrate reduction reaction(NitRR)represents a promising approach toward achieving economically and environmentally sustainable ammonia.However,it remains a challenge to regulate the size effect of electrocatalysts to optimize the catalytic activity and ammonia selectivity.Herein,the Cu-based catalysts were tailored at the atomic level to exhibit a size gradient ranging from single-atom catalysts(SACs,0.15–0.35 nm)to single-cluster catalysts(SCCs,1.0–2.8 nm)and nanoparticles(NPs,20–30 nm),with the aim of studying the size effect for the NO_(3)^(-)-to-NH_(3) reduction reaction.Especially,the Cu SCCs exhibit enhanced metal–substrate and metal–metal interactions by taking advantageous features of Cu SACs and Cu NPs.Thus,Cu SCCs achieve exceptional electrocatalytic performance for the NitRR with a maximum Faradaic efficiency of ca.96%NH_(3)and the largest yield rate of ca.1.99 mg·h^(-1)·cm^(-2) at-0.5 V vs.reversible hydrogen electrode(RHE).The theoretical calculation further reveals the size effect and coordination environment on the high catalytic activity and selectivity for the NitRR.This work provides a promising various size-controlled design strategy for aerogel-based catalysts effectively applied in various electrocatalytic reactions.
基金supported by the National Key R&D Program of China(Grant Nos.2020YFE0202200 and 2017YFC1700105)the National Natural Science Foundation of China(Grant Nos.31601064,31871341,and 32088101)+1 种基金the Beijing Nova Program of China(Grant No.Z171100001117117)the State Key Laboratory of Proteomics of China(Grant No.SKLPO202010)。
文摘After decades of development,protein and peptide drugs have now grown into a major drug class in the marketplace.Target identification and validation are crucial for the discovery of protein and peptide drugs,and bioinformatics prediction of targets based on the characteristics of known target proteins will help improve the efficiency and success rate of target selection.However,owing to the developmental history in the pharmaceutical industry,previous systematic exploration of the target spaces has mainly focused on traditional small-molecule drugs,while studies related to protein and peptide drugs are lacking.Here,we systematically explore the target spaces in the human genome specifically for protein and peptide drugs.Compared with other proteins,both successful protein and peptide drug targets have many special characteristics,and are also significantly different from those of small-molecule drugs in many aspects.Based on these features,we develop separate effective genome-wide target prediction models for protein and peptide drugs.Finally,a user-friendly web server,Predictor Of Protein and Pept Ide drugs’therapeutic Targets(POPPIT)(http://poppit.ncpsb.org.cn/),is established,which provides not only target prediction specifically for protein and peptide drugs but also abundant annotations for predicted targets.