Integration of Artificial Intelligence, Blockchain, and Wearable Technology for Chronic Disease Management: A New Paradigm in Smart Healthcare

Chronic diseases are a growing concern worldwide,with nearly 25% of adults suffering from one or more chronic health conditions,thus placing a heavy burden on individuals,families,and healthcare systems.With the advent of the“Smart Healthcare”era,a series of cutting-edge technologies has brought new experiences to the management of chronic diseases.Among them,smart wearable technology not only helps people pursue a healthier lifestyle but also provides a continuous flow of healthcare data for disease diagnosis and treatment by actively recording physiological parameters and tracking the metabolic state.However,how to organize and analyze the data to achieve the ultimate goal of improving chronic disease management,in terms of quality of life,patient outcomes,and privacy protection,is an urgent issue that needs to be addressed.Artificial intelligence(AI)can provide intelligent suggestions by analyzing a patient’s physiological data from wearable devices for the diagnosis and treatment of diseases.In addition,blockchain can improve healthcare services by authorizing decentralized data sharing,protecting the privacy of users,providing data empowerment,and ensuring the reliability of data management.Integrating AI,blockchain,and wearable technology could optimize the existing chronic disease management models,with a shift from a hospital-centered model to a patient-centered one.In this paper,we conceptually demonstrate a patient-centric technical framework based on AI,blockchain,and wearable technology and further explore the application of these integrated technologies in chronic disease management.Finally,the shortcomings of this new paradigm and future research directions are also discussed.

Novel DDoS Feature Representation Model Combining Deep Belief Network and Canonical Correlation Analysis

Distributed denial of service(DDoS)attacks launch more and more frequently and are more destructive.Feature representation as an important part of DDoS defense technology directly affects the efficiency of defense.Most DDoS feature extraction methods cannot fully utilize the information of the original data,resulting in the extracted features losing useful features.In this paper,a DDoS feature representation method based on deep belief network(DBN)is proposed.We quantify the original data by the size of the network flows,the distribution of IP addresses and ports,and the diversity of packet sizes of different protocols and train the DBN in an unsupervised manner by these quantified values.Two feedforward neural networks(FFNN)are initialized by the trained deep belief network,and one of the feedforward neural networks continues to be trained in a supervised manner.The canonical correlation analysis(CCA)method is used to fuse the features extracted by two feedforward neural networks per layer.Experiments show that compared with other methods,the proposed method can extract better features.

Dynamic Characteristics Analysis on MHTGR Plant’s Secondary Side Fluid Flow Network

Multipe NSSS (Nuclear Steam Supply System) modules use the common feeding-water system to drive the common turbine power generation set. The SSFFN (secondary side fluid flow network) of MHTGR plant has features i.e. strong-coupling and nonlinearity. A wide range of power switching operation will cause unsteady flow, which may destroy the working elements and will be a threat for normal operation. To overcome those problems, a differential-algebraic model and PI controllers are designed for the SSFFN. In MATLAB\SIMULINK environment, a simulation platform is established and used to make a simulation of SSFFN of a MHTGR plant with two NSSS modules, which uses feedwater valves to control the mass flow rate in each module instead of feedwater pump. Results reflect good robustness of controllers.

Prognostic value of sorting nexin 10 weak expression in stomach adenocarcinoma revealed by weighted gene coexpression network analysis

AIM TO detect significant clusters of co-expressed genes associated with tumorigenesis that might help to predict stomach adenocarcinoma （SA） prognosis.METHODS The Cancer Genome Atlas database was used to obtain RNA sequences as well as complete clinical data of SA and adjacent normal tissues from patients. Weighted gene co-expression network analysis （WGCNA） was used to investigate the meaningful module along with hub genes. Expression of hub genes was analyzed in 362 paraffin-embedded SA biopsy tissues by immunohistochemical staining. Patients were classified into two groups （according to expression of hub genes）： Weak expression and over-expression groups. Correlation of biomarkers with clinicopathological factors indicated patient survival.RESULTS Whole genome expression level screening identified 6,231 differentially expressed genes. Twenty-four co- expressed gene modules were identified using WGCNA. Pearson＇s correlation analysis showed that the tan module was the most relevant to tumor stage （r = 0.24, P = 7 × 10 -6）. In addition, we detected sorting nexin （SNX）10 as the hub gene of the tan module. SNX10 expression was linked to T category （P = 0.042, x2= 8.708）, N category （P = 0.000, x2= 18.778）, TNM stage （P = 0.001, x2 = 16.744） as well as tumor differentiation （P = 0.000,x2= 251.930）. Patients with high SNX10 expression tended to have longer diseasefree survival （DFS; 44.97 mo vs 33.85 mo, P = 0.000） as well as overall survival （OS; 49.95 vs 40.84 mo, P = 0.000） in univariate analysis. Multivariate analysis showed that dismal prognosis could be precisely predicted clinicopathologically using SNX10 [DFS： P = 0.014, hazard ratio （HR） = 0.698, 95% confidence interval （CI）： 0.524-0.930, OS： P = 0.017, HR = 0.704, 95%CI： 0.528-0.940].CONCLUSION This study provides a new technique for screening prognostic biomarkers of SA. Weak expression of SNX10 is linked to poor prognosis, and is a suitable prognostic biomarker of SA.

ON THE NUCLEARITY OF COMPLETELY 1-SUMMING MAPPING SPACES

In this paper,we investigate theλ-nuclearity in the system of completely 1-summing mapping spaces(Π1(⋅,⋅),π1).In Section 2,we obtain that C is the unique operator space that is nuclear in the system(Π1(⋅,⋅),π1).We generalize some results in Section 2 toλ-nuclearity in Section 3.

PD Power-Level Control Design for MHTGRs

Due to its inherent safety feature, the modular high temperature gas-cooled reactor (MHTGR) has been seen as one of the best candidates in building next generation nuclear plants (NGNPs). Since the MHTGR dynamics has high nonlinearity, it is necessary to develop nonlinear power-level controller which is not only beneficial to the safe, stable, efficient and autonomous operation of the MHTGR but also easy to be implemented practically. In this paper, based on the concept of shiftedectropy and the physically-based control design approach, it is proved theoretically that the simple proportional-differential (PD) output-feedback power-level control can provide globally asymptotic closed-loop stability. Numerical simulation results verify the theoretical results and show the influence of the controller parameters to the dynamic response.

Ultra-fast and high-efficient synthesis of caffeic acid phenethyl ester by microwave assistant ionic liquids catalysis

Caffeic acid phenethyl ester (CAPE), a natural and rare ingredient with several biological activities, was successfully synthesized from caffeic acid (CA) and phenylethanol (PE) by microwave assistant coupled with ionic liquids (ILs) catalysis. Four ILs, acted as both solvent and catalyst in this chemical synthesis, were optimized. Among them, [Bmim] [PF6] was the best with the highest CA conversion. 95% conversion was achieved under substrate molar ratio 4:1 (PE/CA, n/n), IL content 7:1 (IL/CA, w/w), microwave power 200 W, at 135 oC for 7 min. This study might be attributed to developing new chemical reaction system to produce caffeic acid derived esters.

Nuclearity and Finite-Representability in the System of Completely Integral Mapping Spaces

In this paper,we investigate local properties in the system of completely integral mapping spaces.We introduce notions of injectivity,local reflexivity,exactness,nuclearity,finite-represent ability and WEP in the system of completely integral mapping spaces.First we obtain that any finite-dimensional operator space is injective in the system of completely integral mapping spaces.Furthermore we prove that C is the unique nuclear operator space and the unique exact operator space in this system.We also show that C is the unique operator space which is finitely representable in{T_(n)}n∈Nin this system.As corollaries,Kirchberg’s conjecture and QWEP conjecture in the system of completely integral mapping spaces are false.

Abundance and sources of particulate polycyclic aromatic hydrocarbons and aromatic acids at an urban site in central China

We conducted a simultaneous field study of PM_(2.5)-bound particulate polycyclic aromatic hydrocarbons(PAHs)and aromatic acids(AAs)in a polluted city Zhengzhou to explore the concentration,sources and potential conversion pathways between PAHs and AAs in different seasons.The average concentrations of PM_(2.5),28PAHs and 8AAs during the sampling period were 77μg/m^(3),75 ng/m^(3),and 283 ng/m^(3),respectively.The concentration of both28PAHs and 8AAs were highest in winter and lowest in summer with ratios of 6.3 and 2.3,respectively.PAHs with 5-7 rings were the main components of PAHs(52%),followed by 4rings PAHs(30%)and 2-3 rings PAHs(18%).According to the source appointment results obtained by positive matrix factorization,the main sources of PAHs were combustion and vehicle emissions,which account for 37%and 34%,respectively.8AAs were divided into three groups,including four benzene dicarboxylic acids(B2CAs),three benzene tricarboxylic acids(B3CAs)and one benzene tetracarboxylic acid(B4CA).And interspecies correlation analysis with PM_(2.5)source markers were used to investigate potential sources.Phthalic acid(o-Ph)was the most abundant specie of 8AAs(157 ng/m^(3),55%of 8AAs),which was well correlated with sulfate.Meanwhile,B3CAs and B4CA were highly correlated with sulfate and weakly correlated with levoglucosan,suggesting that secondary formation was their main source.As logical oxidation products of PAHs,o-Ph and B3CAs showed good correlations with a number of PAHs,indicating possible photochemical oxidation pathway by PAHs.In addition,O_(3),NO_(2),temperature and relative humidity have positive effects on the secondary formation of B3CAs.

Ultra-thin ALD CoO_(x)-ZnO heterogenous films as highly sensitive and environmentally friendly H_(2)S sensor

To obtain environmentally friendly,integrated and miniaturized gas sensors for the increasing request for the Internet of Things industry and other relative areas,the ultra-thin CoO_(x)/Zn O heterogeneous film with active interfacial sites was in-situ deposited on micro-electro-mechanical systems(MEMS)as H_(2)S sensor.Atomic layer deposition(ALD)was employed to in-situ fabricate the uniform Zn O thin film.ALD CoO_(x)was deposited on ZnO surface to obtain CoO_(x)/Zn O heterojunction and active interfacial sites.The ultra-thin film(20 nm)with 50 ALD Co O_(x)decorated on 250 ALD Zn O displays excellent sensing performance,including very high response(4.45@200×10^(-9))and selectivity to H_(2)S with a limit of detection(LOD)of 0.38×10^(-9),long-term sensing stability,high response/recovery performance(7.5 s/15.7 s)and mechanical strength at 230。C.Reasons for the high sensing performance of CoO_(x)/Zn O have been confirmed by series of characterizations and density functional theory(DFT)calculation.Heterojunction film thickness with Debye length,the oxygen vacancies and the synergistic effect of active interfacial sites are main reasons for the high sensing performance.The strategy by fabrication of CoO_(x)/Zn O heterogeneous film within Debye length and employing synergistic effect of active interfacial sites offers a promising route for the design of environmentally friendly gas sensors.Furthermore,the ALD technique offers a facile in-situ strategy and high-throughput fabrication of MEMS gas sensors.

腹直肌筋膜-肋软骨颗粒复合体在单侧唇裂二期鼻整形中的应用

目的:探讨腹直肌筋膜包裹肋软骨颗粒作为鼻背移植物应用于单侧唇裂继发鼻畸形整复中的治疗效果。方法:回顾性分析35例单侧唇裂继发鼻畸形患者,采用腹直肌筋膜包裹肋软骨颗粒作为鼻背移植物矫正鼻背畸形。通过拍摄术前、术后二维照片测量鼻侧貌美学角度。统计术后患者满意度。结果:患者术后鼻面角、鼻尖旋转度较术前明显增大,鼻颏角减小,鼻孔轴线角比值增大,差异有统计学意义(P<0.05)。患者鼻畸形矫正程度显著,患者对手术效果满意。结论:腹直肌筋膜包裹肋软骨颗粒在单侧唇裂继发鼻畸形整复中可有效抬高鼻背,改善鼻侧貌美学曲线,在临床上具有推广意义。

Age-period-cohort analysis of pulmonary tuberculosis reported incidence, China, 2006-2020

Background:Tuberculosis(TB)poses a severe public health challenge in China and worldwide.This study evaluated the effects of age,period,and birth cohort on reported incidence trends of TB based on population and refined the characteristics of high-risk groups.Methods:Aggregate data that reported pulmonary tuberculosis(PTB)cases from China Tuberculosis Management Information System(TBIMS)from 2006 to 2020 were used to analyze effect coefficients through the age-period-cohort(APC)model based on intrinsic estimator(IE)method,and converted them into relative risk(RR)to estimate trends.Results:A total of 14.82 million cases of PTB were reported in China from 2006 to 2020,showing a continuous downward trend.The reporting rate increased with age by age group,with 70-74 years old being 2-3 times higher than that in 20-24 years old.APC analysis model showed that age effects were bimodal in 20-24 years old[RR=2.29,95%confidence interval(CI):1.73-3.03]and 70-74 years old(RR=1.95,95%CI:1.67-2.27),and lower than the overall average in the groups under 15 years old.Stratified results showed that the risk was higher for women under age 40 than men and higher for men over 40.The risk was higher in urban than in rural areas under 30 years old and slightly higher in rural than in urban between 30 and 64 years old.The risk for 15-34 years old was significantly higher in the east than in other regions.The period effects showed a decreasing trend,and the risk was higher in rural in recent years.Except for cohorts born in 1961-1965 and 2001-2005,where theRR increased,the later the cohort was born,the lower the risk.The cohort 1926-1930 in eastern had the highest risk(RR=3.49,95%CI:2.44-4.98).Conclusions:The reported incidence of PTB continued to decline in China from 2006 to 2020.The young(20-24 years old)and the elderly(70-74 years old)were equally at high risk.There were differences in the age,period and cohort effects on PTB incidence among gender,urban-rural and regions.Our findings better reflected the characteristics of high-risk populations,thus contributing to the development of timely and effective intervention strategies,and providing clues for etiological research.

A Class of the Hamming Weight Hierarchy of Linear Codes with Dimension 5

The weight hierarchy of a [n, k; q] linear code C over Fq is the sequence （d1,…, dr,… , dk）, where dr is the smallest support weight of an r-dimensional subcode of C. In this paper, by using the finite projective geometry method, we research a class of weight hierarchy of linear codes with dimension 5. We first find some new pre- conditions of this class. Then we divide its weight hierarchies into six subclasses, and research one subclass to determine nearly all the weight hierarchies of this subclass of weight hierarchies of linear codes with dimension 5.

Mono-dispersed Ag nanoparticles decorated graphitic carbon nitride:An excellent lubricating additive as PPESK composite film

Studies show that two dimensional(2D)nanomaterial and its hybrid have a great promise in tribology for the special laminar microstructure.However,the majority of performed investigations about 2D graphitic carbon nitride(g-C_(3)N_(4))nanosheets are most focused on energy storage,catalysis,adsorption,rarely tribology.In the present study,g-C_(3)N_(4) supporting mono-dispersed Ag nanoparticle hybrid(g-C_(3)N_(4)/Ag)is prepared,and its microstructure and chemical composition are determined.More specifically,the tribological performance as the lubricating additive of poly phthalazinone ether sulfone ketone(PPESK)composite is investigated using the ball-on-disc friction tester.Moreover,the corresponding enhancement mechanism is well proposed based on the experimental analysis and theoretical simulation.Obtained results show that Ag nanoparticles with a size of about 10-20 nm are homogeneously anchored on g-C_(3)N_(4) nanosheets,favoring for good compatibility between g-C_(3)N_(4)/Ag and PPESK.It is found that when 0.3 wt%of g-C_(3)N_(4)/Ag is added to PPESK,the friction coefficient and wear rate of PPESK decrease by 68.9%and 97.1%,respectively.These reductions are mainly attributed to the synergistic self-lubricating effect of Ag nanoparticles and g-C_(3)N_(4) nanosheet,the formation of transfer film,as well as the limited effect of g-C_(3)N_(4)/Ag on the shear deformation of PPESK composite film.Furthermore,it is found that the proposed g-C_(3)N_(4)/Ag-PPESK composite still keeps reasonable friction-reducing and wear-resistant properties under heavy loads and high rotating speeds.The present study demonstrates that the proposed g-C_(3)N_(4)/Ag hybrid is an excellent lubricating additive for polymer composites.

An efficient synthesis of 2-(guaiazulen-1-yl)furan derivatives via intramolecular Wittig reactions

An efficient and mild synthesis of 2-（guaiazulen-l-yl）furans, starting from easily accessible 1-（3-aryl-2- cyanopropenoyl）guaiazulenes, tributylphosphine and acyl chlorides, is described. The strategy employs the intramolecular Wittig protocol as a key step to append the crucial furan ring, leading to the highly functional furans in good yields.

Application of Disability-Adjusted Life Years to Evaluate the Burden and Trend of Tuberculosis — China, 1990–2019

Summary What is already known about this topic?China is a country with a high burden of tuberculosis(TB).However,the evaluation of TB burden is usually based on traditional epidemiological indicators,and disability-adjusted life year(DALY)is rarely applied.What is added by this report?In China,the number of DALYs caused by TB in 2019 was estimated to be 1.36 million,and the agestandardized rate(ASR)was 86.46/100,000.The DALYs of TB decreased significantly from 1990 to 2019,with the largest decline from 2001 to 2010.The burden is higher among men than women,and the highest among the elderly.What are the implications for public health practice?Application of DALYs can reflect the damage in health to China’s residents caused by tuberculosis.In the future,we should strengthen research,monitor years lived with disability(YLDs),and reduce the burden of the elderly and men.Cost-effective analysis based on DALYs should be conducted to provide a scientific basis for decision-making.

Kirchberg’s conjecture in the system of Hilbert space factorable mapping spaces

This study aims to introduce the notions of injectivity, local reflexivity, exactness, and nuclearity in the system(Γ2c(·, ·), γ2c(·)). We find that every dual operator space is injective in the system(Γ2c(·, ·), γ2c(·)) and nuclearity is equivalent to exactness in this system. As a corollary, we prove that Kirchberg’s conjecture on the equivalence of exactness and local reflexivity for C*-algebras is false in this system, i.e., there exists a C*-algebra A that is locally reflexive in this system but is not exact in this system.

A Weak* Similarity Degree Characterization for Injective von Neumann Algebras

In this note, we show that avon Neumann algebra M is injective if and only if the weak＊ similarity degree d.（M） ≤ 2.

The Existence of Maximal w^＊-closed Submodules in Nest Algebra Modules

Using the technique of annihilators, we characterize the w^＊-closure of the finite-partition submodule R（N, ～） of a weakly closed nest algebra module U completely; and by virtue of this characterization, we obtain a sufficient and necessary condition for U to have a maximal w^＊-closed submodule.

Comparison of Risks of Thromboembolism of Drospirenone-Containing and Nondrospirenone -Containing Combined Oral Contraceptive Use: A Meta-Analysis

This study aimed to estimate the risk of venous thromboembolism(VTE),arterial thromboembolism(ATE),and other side effects following the use of drospirenone(DRSP)-containing combined oral contraceptives(COCs).When compared with non-DRSP-containing COCs,DRSP-containing COCs decreased the risk of VTE by 15%in the overall study population,although this was not statistically significant(adjusted hazard ratio/risk ratio[95%confidence interval]0.85[0.69,1.04]).DRSP-containing COCs also showed significant benefits in terms of ATE risk.The body mass index of the subjects significantly decreased by 0.64 kg/m^(2) after taking the DRSP-containing COCs for 6 months.We concluded that DRSP-containing COCs were safe for use and could be broadly recommended.