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Development and evaluation of a RT-RAA-combined CRISPR/Cas12a assay for the detection of African horse sickness virus
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作者 Yingzhi Zhang Lei Na +5 位作者 Kui Guo Jinhui Wang zhe hu Cheng Du Xuefeng Wang Xiaojun Wang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第12期4267-4271,共5页
African horse sickness(AHS)is an acute and fatal vectorborne infectious disease of equids,caused by the African horse sickness virus(AHSV).The World Organization for Animal Health(WOAH)has classified AHS as a notifiab... African horse sickness(AHS)is an acute and fatal vectorborne infectious disease of equids,caused by the African horse sickness virus(AHSV).The World Organization for Animal Health(WOAH)has classified AHS as a notifiable animal disease,and AHS has also been classified as a Class I animal infectious disease in China.AHS is mainly found in Africa,the Middle East and the Arabian Peninsula.China is currently recognized by the WOAH as an AHS-free zone. 展开更多
关键词 HAS HORSE SICKNESS
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Functional porous carbon-based composite electrode materials for lithium secondary batteries 被引量:5
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作者 Kai Zhang zhe hu Jun Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2013年第2期214-225,共12页
The synthetic routes of porous carbons and the applications of the functional porous carbon-based composite electrode materials for lithium secondary batteries are reviewed. The synthetic methods have made great break... The synthetic routes of porous carbons and the applications of the functional porous carbon-based composite electrode materials for lithium secondary batteries are reviewed. The synthetic methods have made great breakthroughs to control the pore size and volume, wall thickness, surface area, and connectivity of porous carbons, which result in the development of functional porous carbon-based composite electrode materials. The effects of porous carbons on the electrochemical properties are further discussed. The porous carbons as ideal matrixes to incorporate active materials make a great improvement on the electrochemical properties because of high surface area and pore volume, excellent electronic conductivity, and strong adsorption capacity. Large numbers of the composite electrode materials have been used for the devices of electrochemical energy conversion and storage, such as lithium-ion batteries (LIBs), Li-S batteries, and Li-O2 batteries. It is believed that functional porous carbon-based composite electrode materials will continuously contribute to the field of lithium secondary batteries. 展开更多
关键词 porous carbons functional materials composite electrode materials synthetic method lithium secondary batteries
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Hydrothermal synthesis of spindle-like Li_2FeSiO_4-C composite as cathode materials for lithium-ion batteries 被引量:4
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作者 Haiyan Gao zhe hu +3 位作者 Kai Zhang Fangyi Cheng Zhanliang Tao Jun Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2014年第3期274-281,共8页
In this paper,we report on the preparation of Li2FeSiO4,sintered Li2FeSiO4,and Li2FeSiO4-C composite with spindle-like morphologies and their application as cathode materials of lithium-ion batteries.Spindle-like Li2F... In this paper,we report on the preparation of Li2FeSiO4,sintered Li2FeSiO4,and Li2FeSiO4-C composite with spindle-like morphologies and their application as cathode materials of lithium-ion batteries.Spindle-like Li2FeSi04 was synthesized by a facile hydrothermal method with(NH4)2Fe(SO4)2 as the iron source.The spindle-like Li2FeSiO4 was sintered at 600 ℃ for 6 h in Ar atmosphere.Li2FeSiO4-C composite was obtained by the hydrothermal treatment of spindle-like Li2FeSiO4 in glucose solution at 190 ℃ for 3 h.Electrochemical measurements show that after carbon coating,the electrode performances such as discharge capacity and high-rate capability are greatly enhanced.In particular.Li2FeSiO4-C with carbon content of 7.21 wt%delivers the discharge capacities of 160.9 mAh·g-1 at room temperature and 213 mAh·g-1 at45℃(0.1 C),revealing the potential application in lithium-ion batteries. 展开更多
关键词 Li2FeSiO4-C composite spindle like hydrothermal synthesis cathode material lithium-ion battery
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Development and validation of a questionnaire-based risk scoring system to identify individuals at high risk for gastric cancer in Chinese populations 被引量:4
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作者 Ren Zhou Hongchen zheng +11 位作者 Mengfei Liu zhen Liu Chuanhai Guo Hongrui Tian Fangfang Liu Ying Liu Yaqi Pan huanyu Chen zhe hu Hong Cai Zhonghu He Yang Ke 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2021年第6期649-658,共10页
Objective:This study aimed to develop and validate a risk scoring system to identify high-risk individuals carrying malignant lesions in stomach for tailored gastric cancer screening.Methods:A gastric cancer risk scor... Objective:This study aimed to develop and validate a risk scoring system to identify high-risk individuals carrying malignant lesions in stomach for tailored gastric cancer screening.Methods:A gastric cancer risk scoring system(GC-RSS)was developed based on questionnaire-based predictors for gastric cancer derived from systematic literature review.To assess the capability of this system for discrimination,risk scores for 8,214 and 7,235 outpatient subjects accepting endoscopic examination in two endoscopy centers,and 32,630 participants in a community-based cohort in China were calculated to plot receiver operating characteristic curves and generate area under the curve(AUC).To evaluate the performance of GC-RSS,the screening proportion,sensitivity and detection rate ratio compared to universal screening were used under different risk score cutoff values.Results:GC-RSS comprised nine predictors including advanced age,male gender,low body mass index(<18.5 kg/m^(2)),family history of gastric cancer,cigarette smoking,consumption of alcohol,preference for salty food,irregularity of meals and consumption of preserved food.This tool performed well in determining the risk of malignant gastric lesions with AUCs of 0.763,0.706 and 0.696 in three validation sets.When subjects with risk scores≥5 were evaluated with endoscopy,nearly 50%of these endoscopies could be saved with a detection rate of over 1.5 times achieved.When the cutoff was set at 8,only about 10%of subjects with the highest risk would be offered endoscopy,and detection rates for gastric cancer could be increased 2-4 fold compared to universal screening.Conclusions:An effective questionnaire-based GC-RSS was developed and validated.This tool may play an important role in establishing a tailored screening strategy for gastric cancer in China. 展开更多
关键词 Cancer screening external validation gastric cancer risk scoring system
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Oral microbiome and risk of malignant esophageal lesions in a high-risk area of China:A nested case-control study 被引量:3
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作者 Fangfang Liu Mengfei Liu +17 位作者 Ying Liu Chuanhai Guo Yunlai Zhou Fenglei Li Ruiping Xu zhen Liu Qiuju Deng Xiang Li Chaoting Zhang Yaqi Pan Tao Ning Xiao Dong zhe hu huanyu Bao Hong Cai Isabel Dos Santos Silva Zhonghu He Yang Ke 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2020年第6期742-754,共13页
Objective:We aimed to prospectively evaluate the association of oral microbiome with malignant esophageal lesions and its predictive potential as a biomarker of risk.Methods:We conducted a case-control study nested wi... Objective:We aimed to prospectively evaluate the association of oral microbiome with malignant esophageal lesions and its predictive potential as a biomarker of risk.Methods:We conducted a case-control study nested within a population-based cohort with up to 8 visits of oral swab collection for each subject over an 11-year period in a high-risk area for esophageal cancer in China.The oral microbiome was evaluated with 16 S ribosomal RNA(rRNA)gene sequencing in 428 pre-diagnostic oral specimens from 84 cases with esophageal lesions of severe squamous dysplasia and above(SDA)and 168 matched healthy controls.DESeq analysis was performed to identify taxa of differential abundance.Differential oral species together with subject characteristics were evaluated for their potential in predicting SDA risk by constructing conditional logistic regression models.Results:A total of 125 taxa including 37 named species showed significantly different abundance between SDA cases and controls(all P<0.05&false discovery rate-adjusted Q<0.10).A multivariate logistic model including 11 SDA lesion-related species and family history of esophageal cancer provided an area under the receiver operating characteristic curve(AUC)of 0.89(95%CI,0.84-0.93).Cross-validation and sensitivity analysis,excluding cases diagnosed within 1 year of collection of the baseline specimen and their matched controls,or restriction to screenendoscopic-detected or clinically diagnosed case-control triads,or using only bacterial data measured at the baseline,yielded AUCs>0.84.Conclusions:The oral microbiome may play an etiological and predictive role in esophageal cancer,and it holds promise as a non-invasive early warning biomarker for risk stratification for esophageal cancer screening programs. 展开更多
关键词 Early warning biomarker esophageal squamous cell carcinoma oral microbiome risk prediction
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A simple method of depressing numerical dissipation effects during wave simulation within the Euler model 被引量:1
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作者 zhe hu Xiaoying Zhang +3 位作者 Weicheng Cui Fang Wang Xiaowen Li Yan Li 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2020年第1期141-156,共16页
Numerical wave tanks are widely-acknowledged tools in studying waves and wave-structure interactions. They can generate waves under realistic scales and offers more information on the fluid field. However, most numeri... Numerical wave tanks are widely-acknowledged tools in studying waves and wave-structure interactions. They can generate waves under realistic scales and offers more information on the fluid field. However, most numerical wave tanks suffer from issues known as the numerical dissipation and numerical dispersion. The former causes wave energy to be slowly dissipated and the latter shifts wave frequencies during wave propagation. This paper proposes a simple method of depressing numerical dissipation effects on the basis of solving Euler equations using the finite difference method(FDM). The wave propagation solutions are solved analytically taking into account the influence of the damping terms. The main idea of the method is to append a source term to the momentum equation, whose strength is determined by how strong the numerical damping effect is. The method is verified by successfully depressing numerical effects during the simulation of regular linear waves, Stokes waves and irregular waves. By applying the method, wave energy is able to be close to its initial value after long distance of travel. 展开更多
关键词 numerical dissipation numerical wave tank wave simulation numerical damping reduction finite difference method
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Real time high accuracy phase contrast imaging with parallel acquisition speckle tracking 被引量:1
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作者 zhe hu Wen-Qiang hua Jie Wang 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第6期282-286,共5页
X-ray speckle tracking based methods can provide results with best reported angular accuracy up to 2 nrad. However,duo to the multi-frame requirement for phase retrieval and the possible instability of the x-ray beam,... X-ray speckle tracking based methods can provide results with best reported angular accuracy up to 2 nrad. However,duo to the multi-frame requirement for phase retrieval and the possible instability of the x-ray beam, mechanical and background vibration, the actual accuracy will inevitably be degraded by these time-dependent fluctuations. Therefore,not only spatial position, but also temporal features of the speckle patterns need to be considered in order to maintain the superiority of the speckle-based methods. In this paper, we propose a parallel acquisition method with advantages of real time and high accuracy, which has potential applicability to dynamic samples imaging as well as on-line beam monitoring.Through simulations, we demonstrate that the proposed method can reduce the phase error caused by the fluctuations to1% at most compared with current speckle tracking methods. Meanwhile, it can keep the accuracy deterioration within0.03 nrad, making the high theoretical accuracy a reality. Also, we find that waveforms of the incident beam have a little impact on the phase retrieved and will not influence the actual accuracy, which relaxes the requirements for speckle-based experiments. 展开更多
关键词 phase contrast imaging near field speckle grating splitter
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Sensitive detection of alkaline phosphatase based on terminal deoxynucleotidyl transferase and endonuclease Ⅳ-assisted exponential signal amplification
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作者 Weicong Ye Longjie Li +4 位作者 Zishan Feng Bocheng Tu zhe hu Xianjin Xiao Tongbo Wu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2022年第4期692-697,共6页
Alkaline phosphatase(ALP)is widely expressed in human tissues.ALP plays an important role in the dephosphorylation of proteins and nucleic acids.Therefore,quantitative analysis of ALP plays a vital role in disease dia... Alkaline phosphatase(ALP)is widely expressed in human tissues.ALP plays an important role in the dephosphorylation of proteins and nucleic acids.Therefore,quantitative analysis of ALP plays a vital role in disease diagnosis and the development of biological detection methods.Terminal deoxynucleotidyl transferase(TdT)catalyzes continuous polymerization of deoxynucleotide triphosphates at the 30-OH end of single-stranded DNA in the absence of a template.In this study,we developed a highly sensitive and selective method based on TdT and endonuclease Ⅳ(Endo Ⅳ)to quantify ALP activity.After ALP hydrolyzes the 30-PO_(4) end of the substrate and generates 30-OH,TdT can effectively elongate the 30-OH end with deoxynucleotide adenine triphosphate(dATP)and produce a poly A tail,which can be detected by the poly T probes.Endo Ⅳ digests the AP site in poly T probes to generate a fluorescent signal and a new 30-OH end,leading to the generation of exponential fluorescence signal amplification.The substrate for TdT elongation was optimized,and a limit of detection of 4.3×10^(-3) U/L was achieved for ALP by the optimized substrate structure.This method can also detect ALP in the cell lysate of a single cell.This work has potential applications in disease diagnosis and biomedical detection. 展开更多
关键词 Alkaline phosphatase Terminal deoxynucleotidyl TRANSFERASE EndonucleaseⅣ Exponential amplification
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CuP_(2) as high-capacity and long-cycle-life anode for potassium-ion batteries
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作者 Lin Li zhe hu +5 位作者 Yong Lu Shuo Zhao Qiu Zhang Qiannan Liu zhenhua Yan Shu-Lei Chou 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2021年第12期246-252,I0005,共8页
Metal phosphides have shown great potential for potassium-ion batteries because of their high theoretical specific capacity.Nevertheless,most of the metal phosphide anodes are plagued by rapid capacity decay(caused by... Metal phosphides have shown great potential for potassium-ion batteries because of their high theoretical specific capacity.Nevertheless,most of the metal phosphide anodes are plagued by rapid capacity decay(caused by the large volume changes during the discharge/charge process),which would restrict their further practical application.Herein,a chemically bonded CuP_(2)/C composite was prepared by a facile high-energy ball milling method.A potassium bis(trifluoromethanesulfonyl)imide(KFSI)-based electrolyte was adopted instead of a conventional KPF6-based electrolyte for the CuP_(2)/C composite anode.Benefiting from the synergistic effects of the formation of strong P-O-C chemical bonds and the KFSIbased electrolyte,the CuP_(2)/C composite anode exhibited high reversible capacity(451.4 mAh g^(-1) at50 mA g^(-1)),excellent rate performance(123.5 mAh g^(-1) at 1000 mA g^(-1)),and superior cycling stability(300 mAh g^(-1) after 100 cycles).This work paves the way for the development of high-performance CuP_(2) anode for potassium-ion batteries. 展开更多
关键词 Potassium-ion batteries CuP_(2)/C composite Metal phosphides P-O-C chemical bond KFSI-based electrolyte
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A Clinical Study of Integrated Traditional Chinese and Western Medicine in the Treatment of Liver-Stomach Disharmony Functional Dyspepsia 被引量:1
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作者 Xiaoqiang Nan zhe hu 《Journal of Clinical and Nursing Research》 2023年第2期86-91,共6页
Objective:To explore the clinical effect of integrated traditional Chinese and Western medicine in the treatment of liver-stomach disharmony functional dyspepsia.Methods:Sixty patients with functional dyspepsia of liv... Objective:To explore the clinical effect of integrated traditional Chinese and Western medicine in the treatment of liver-stomach disharmony functional dyspepsia.Methods:Sixty patients with functional dyspepsia of liver-stomach disharmony type admitted to our hospital from January to August 2022 were selected as research subjects and randomly divided into two groups,a study group and a control group,with 30 cases in each group.The main observations were stomachache or pain over bilateral flanks,emotionally depressed,belching,fullness and discomfort over the abdomen and flanks,acid regurgitation,loss of appetite,frequent sighing,noisy epigastric,and the treatment effect.Results:According to the classification of symptom severity on the traditional Chinese medicine(TCM)symptom score table,statistics were made on the corresponding severity of the main symptoms and secondary symptoms of the two groups of patients,and the data of the two groups were compared by Wilcoxon test.The results showed that there was no significant difference in the distribution of TCM symptoms between the two groups;the study group’s total effective rate of pain relief(recovery+markedly effective+effective)was 96.67%,and Fisher’s χ^(2) test indicated a significant difference in the total effective rate of pain relief between the two groups(P=0.027<0.05).Conclusion:The use of integrated traditional Chinese and western medicine is clearly better than the simple application of western medicine.It is safe and has no side effects.It can be used as a treatment for patients with functional dyspepsia. 展开更多
关键词 Integrated traditional Chinese and Western medicine Disharmony between liver and stomach DYSPEPSIA
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Rapid bacteria identification using structured illumination microscopy and machine learning
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作者 Yingchuan He Weize Xu +3 位作者 Yao Zhi Rohit Tyagi zhe hu Gang Cao 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2018年第1期149-158,共10页
Traditionally,optical microscopy is used to visualize the morphological features of pathogenic bacteria,of which the features are further used for the detection and ident ification of the bacteria.However,due to the r... Traditionally,optical microscopy is used to visualize the morphological features of pathogenic bacteria,of which the features are further used for the detection and ident ification of the bacteria.However,due to the resolution limitation of conventional optical microscopy as well as the lack of standard pattern library for bacteria identification,the ffectiveness of this optical microscopy-based method is limited.Here,we reported a pilot study on a combined use of Structured Illumination Microscopy(SIM)with machine learning for rapid bacteria identification.After applying machine learning to the SIM image datasets from three model bacteria(including Escherichia coli,Mycobacterium smegmatis,and Pseudomonas aeruginosa),we obtained a classifcation accuracy of up to 98%.This study points out a promising possibility for rapid bacterial identification by morphological features. 展开更多
关键词 Structured ilumination microscopy bacterial classification principal component analysis support vector machine random forest
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Data-driven modeling and fault diagnosis for fuel cell vehicles using deep learning 被引量:2
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作者 Yangeng Chen Jingjing Zhang +1 位作者 Shuang Zhai zhe hu 《Energy and AI》 EI 2024年第2期111-124,共14页
The reliability and safety of fuel cell vehicle are crucial for the daily operation. Insulation resistance serves as a crucial index of vehicle reliability, especially when fuel cells operate at high voltages. Low ins... The reliability and safety of fuel cell vehicle are crucial for the daily operation. Insulation resistance serves as a crucial index of vehicle reliability, especially when fuel cells operate at high voltages. Low insulation resistance can lead to vehicle malfunctions, exposing the operator to the risk of electric shock. In this study, long-term insulation resistance data from thirteen vehicles equipped with three different types of fuel cell systems are analyzed to diagnose possible low insulation resistance issues. For this purpose, a robust locally weighted scatterplot smoothing method is utilized to filter the original data. In this research, an insulation variation model is developed using a data-driven long short-term memory neural network to identify insulation resistance value anomalies caused by deionizer failure. The results indicate that the coefficient of determination of the failure model is 99.78 %. Moreover, current model efficiently identifies insulation faults resulting from reliability issues, such as conductivity issues of cooling pipes and erosion of vehicle wiring harnesses. 展开更多
关键词 Fuel cell vehicles Insulation faults RLOWESS LSTM neural network
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Development of bi-oligo(ethylene glycol)-functionalized fluorescent probe for two-photon and noninvasive imaging in Arabidopsis thaliana
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作者 Jingzhi Du Keming Chen +7 位作者 zhenyang Yu Yuhao Qiao Jiaxin Liu Qianqian Zhai zhe hu Sheng-Gang Yang Jun Li huailong Teng 《Advanced Agrochem》 2022年第2期162-173,共12页
Fluorescent probe is an important tool for investigation of biological events in plant tissues.However,the research on small-molecule based fluorescent probe for plant imaging still stays at the initial stage.In order... Fluorescent probe is an important tool for investigation of biological events in plant tissues.However,the research on small-molecule based fluorescent probe for plant imaging still stays at the initial stage.In order to noninvasively achieve the subcellular information of Arabidopsis thaliana,a two-photon and fluorene based fluorophore with a bi-oligo(ethylene glycol)functional group was synthesized.Under the laser's irradiation at 750 nm,the subcellular structures of Arabidopsis thaliana including stomata and root tips were clearly observed without slicing,which displayed significant superiorities over traditional single-photon excitation microscopy.Subsequently,the above functionalized fluorophore was further modified with a recognition group(dipicolylamine)to form a smart fluorescent probe(LJTP1).As results,LJTP1 not only can sensitively detect Cu^(2+)/S^(2-)with fluorescence“on-off-on”response in vitro and in vivo,but also can achieve noninvasive imaging in Arabidopsis thaliana tissues under two-photon microscopy.We believe this study will open up a new mind for noninvasive imaging in plant tissues. 展开更多
关键词 Fluorescent probe Two-photon Plant imaging Dual-functional detection
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脑卒中患者发生深静脉血栓危险因素的Meta分析 被引量:44
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作者 唐文娟 石贞仙 +1 位作者 张彩云 胡喆 《中华护理杂志》 CSCD 北大核心 2019年第7期989-994,共6页
目的明确脑卒中患者发生深静脉血栓的危险因素,为预防脑卒中患者发生深静脉血栓提供依据。方法计算机检索Cochrane Library、PubMed、Embase、中国期刊全文数据库、万方数据库、维普数据库和中国生物医学文献数据库,搜集建库至2018年8... 目的明确脑卒中患者发生深静脉血栓的危险因素,为预防脑卒中患者发生深静脉血栓提供依据。方法计算机检索Cochrane Library、PubMed、Embase、中国期刊全文数据库、万方数据库、维普数据库和中国生物医学文献数据库,搜集建库至2018年8月关于脑卒中患者发生深静脉血栓危险因素的文献,利用RevMan 5.3软件进行Meta分析。结果共纳入14篇文献,包括22项相关危险因素,有统计学意义的危险因素为年龄≥65岁(OR=1.93)、糖尿病(OR=1.63)、冠心病(OR=2.31)、心房颤动(OR=1.55)、瘫痪(OR=7.14)、深静脉穿刺(OR=3.08)、卧床(OR=7.36)、心力衰竭(OR=1.96)、感染(OR=2.48)、入院时美国国立卫生研究院脑卒中评分(OR=5.78)、下肢美国国立卫生研究院脑卒中评分≥2分(OR=2.28)。结论年龄≥65岁、糖尿病、冠心病、心房颤动、瘫痪、有深静脉穿刺史、卧床、心力衰竭、感染等是脑卒中患者深静脉血栓的危险因素。 展开更多
关键词 脑卒中 深静脉血栓 影响因素分析 META分析
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Aqueous synthesis of 79%efficient AgInGaS/ZnS quantum dots for extremely high color rendering white light-emitting diodes 被引量:4
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作者 zhe hu Hanxu Lu +7 位作者 Wenjie Zhou Jinxin Wei Hanqing Dai b Hong Liu Zhiyong Xiong Fengxian Xie Wanlu Zhang Ruiqian Guo 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2023年第3期189-196,共8页
Over the past few decades,I-III-VI quantum dots(QDs)have attracted considerable attention due to their large Stokes shifts,good eco-friendliness,and wide tunable emissions.In this work,a facile microwave-assisted aque... Over the past few decades,I-III-VI quantum dots(QDs)have attracted considerable attention due to their large Stokes shifts,good eco-friendliness,and wide tunable emissions.In this work,a facile microwave-assisted aqueous route using glutathione(GSH)and citric acid(CA)as dual stabilizers is introduced to synthesize AgInGaS/ZnS(AIGS/ZnS)core/shell QDs.An exceptional photoluminescence quantum yield(PL QY)as high as 79%is successfully achieved,boosting the best performance of water-dispersible AIGS QDs.By varying the Ag/Ga ratio,the PL peak wavelength can be tuned from 547 to 616 nm,and luminescent hydrogel films with different colors are obtained by embedding AIGS/ZnS QDs in polyacrylamide/poly-vinyl alcohol(PAAm/PVA)hydrogels.The white light-emitting diode(WLED)with a high color rendering index(CRI)of 92.1(R_(9)=92.0)and a correlated color temperature(CCT)of 3022 K is fabricated using QDs-PAAm/PVA hydrogel films in combination with a blue InGaN LED chip,indicating that the as-prepared QDs are competitive color-conversion materials for WLEDs. 展开更多
关键词 AgInGaS/ZnS Aqueous synthesis Quantum dots White LEDs
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In Vivo Two-photon Calcium Imaging in Dendrites of Rabies Virus-labeled V1 Corticothalamic Neurons 被引量:3
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作者 Yajie Tang Liang Li +5 位作者 Leqiang Sun Jinsong Yu zhe hu Kaiqi Lian Gang Cao Jinxia Dai 《Neuroscience Bulletin》 SCIE CAS CSCD 2020年第5期545-553,共9页
Monitoring neuronal activity in vivo is critical to understanding the physiological or pathological functions of the brain.Two-photon Ca^(2+)imaging in vivo using a cranial window and specific neuronal labeling enable... Monitoring neuronal activity in vivo is critical to understanding the physiological or pathological functions of the brain.Two-photon Ca^(2+)imaging in vivo using a cranial window and specific neuronal labeling enables realtime,in situ,and long-term imaging of the living brain.Here,we constructed a recombinant rabies virus containing the Ca^(2+)indicator GCaMP6 s along with the fluorescent protein DsRed2 as a baseline reference to ensure GCaMP6 s signal reliability.This functional tracer was applied to retrogradely label specific V1-thalamus circuits and detect spontaneous Ca^(2+)activity in the dendrites of V1 corticothalamic neurons by in vivo two-photon Ca^(2+)imaging.Notably,we were able to record single-spine spontaneous Ca2+activity in specific circuits.Distinct spontaneous Ca^(2+)dynamics in dendrites of V1 corticothalamic neurons were found for different V1-thalamus circuits.Our method can be applied to monitor Ca^(2+)dynamics in specific input circuits in vivo,and contribute to functional studies of defined neural circuits and the dissection of functional circuit connections. 展开更多
关键词 In vivo Ca^(2+)imaging Cranial window Two-photon microscopy Rabies virus DENDRITE Primary visual cortex Corticothalamic projection Neural circuit tracing
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Subicular Pyramidal Neurons: A Key to Unlock the ‘‘Black Box’’of Drug Resistance in Temporal Lobe Epilepsy 被引量:5
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作者 zhe hu Xinyi Wang Kai Zhong 《Neuroscience Bulletin》 SCIE CAS CSCD 2019年第6期1123-1125,共3页
Drug resistance is one of the most serious issues in epilepsy.Despite using various appropriate anti-epileptic drugs(AEDs),30%of epilepsy patients are still drugresistant.The percentage of resistance in temporal lobe ... Drug resistance is one of the most serious issues in epilepsy.Despite using various appropriate anti-epileptic drugs(AEDs),30%of epilepsy patients are still drugresistant.The percentage of resistance in temporal lobe epilepsy(TLE)is even higher[1].Although epilepsy surgery and deep brain stimulation are emerging as alternative therapeutic strategies,the curative outcome is still unsatisfactory. 展开更多
关键词 EPILEPSY STIMULATION DRUGS
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Quantum dots-hydrogel composites for biomedical applications 被引量:2
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作者 Wenjie Zhou zhe hu +7 位作者 Jinxin Wei Hanqing Dai Yuanyuan Chen Siyu Liu Zhongtao Duan Fengxian Xie Wanlu Zhang Ruiqian Guo 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第3期1245-1253,共9页
Quantum dots-hydrogel composites are promising new materials that have attracted extensive attention due to their incomparable biocompatibility and acceptable biodegradability, leading to enormous potential applicatio... Quantum dots-hydrogel composites are promising new materials that have attracted extensive attention due to their incomparable biocompatibility and acceptable biodegradability, leading to enormous potential applications for various fields. This review summarizes the recent advances in quantum dots-hydrogel composites with a focus on synthesis methods, including hydrogel gelation in quantum dots(QDs) solution, embedding prepared QDs into hydrogels after gelation, forming QDs in situ within the preformed gel and cross-linking via QDs to form hydrogels. In particularly, biomedical applications as bioimaging,biosensing and drug delivery are also reviewed, followed by a discussion on the inherent challenges of design optimization, biocompatibility and bimodal applications and the prospect of the future development. These results will guide the development of quantum dots-hydrogel composites and provide critical insights to inspire researchers in future. 展开更多
关键词 Quantum dots HYDROGELS BIOIMAGING BIOSENSING Drug delivery
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Spatiotemporal patterns of sediment deposition on the northern slope of the South China Sea in the last 150,000 years 被引量:1
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作者 zhe hu Bao-Qi huang +1 位作者 Le-Jun Liu Na Wang 《Journal of Palaeogeography》 SCIE CSCD 2021年第3期399-415,共17页
The source-to-sink system of the northern South China Sea(SCS) has been widely discussed during the past few decades. Sr–Nd isotope, clay minerals and trace elements were extensively used as the proxies of sediment p... The source-to-sink system of the northern South China Sea(SCS) has been widely discussed during the past few decades. Sr–Nd isotope, clay minerals and trace elements were extensively used as the proxies of sediment provenance, however, still little is known about the transport processes and controlling mechanisms on detailed spatiotemporal scales due to the limitations of these methods. Here we put forward the new provenance proxies RAKand RKCNbased on major element compositions to study the spatiotemporal changes in sediment provenance since 150 ka mainly from four sites, DLW3101, MD12-3429, ZHS-176 and MD12-3432, which are located on the northern SCS continental slope. Our results show that, spatially, the pathways and intensities of contour currents and gravity flows play important roles in sediment transport. For alongslope processes, the South China Sea Branch of Kuroshio Current(SCSBKC) and the Deep Water Current(DWC) transport sediments from southwestern Taiwan,while the Intermediate Water Current(IWC) can carry sediments from Hainan, the Red River or the Indochina Peninsula. For downslope processes, gravity flows transport materials from the Pearl River delta and shelf to the slope. Moreover, seafloor bathymetry influences sediment transport by altering the pathways of ocean currents.Temporally, the impacts of sea level and monsoon rainfall fluctuations are always superimposed over the last 150 ka. Sea level fluctuations could significantly change the distance from the Pearl River estuary to the slope, while variations in the East Asian summer monsoon(EASM) rainfall would affect continental erosion rates in the source regions. 展开更多
关键词 South China Sea Sediment transport Element composition Ocean current Sea level QUATERNARY
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Prevalence and molecular epidemiology of equine piroplasmosis in China:a neglected tick-borne disease 被引量:1
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作者 Kewei Chen zhe hu +6 位作者 Jingkun Li Jingfei Wang Diqiu Liu Ting Qi Wei Guo Cheng Du Xiaojun Wang 《Science China(Life Sciences)》 SCIE CAS CSCD 2022年第2期445-447,共3页
Dear Editor,Equine piroplasmosis(EP)is an infectious,tick-borne dis-ease caused by the hemoprotozoan parasites Theileria equi(T.equi)and Babesia caballi(B.caballi).EP affects all wild and domestic equids,and clinical ... Dear Editor,Equine piroplasmosis(EP)is an infectious,tick-borne dis-ease caused by the hemoprotozoan parasites Theileria equi(T.equi)and Babesia caballi(B.caballi).EP affects all wild and domestic equids,and clinical presentation is related to intravascular hemolysis and associated systemic illness(Scoles and Ueti,2015).This disease has considerable ve-terinary and economic impact on the equine industry worldwide,and is listed as a reportable disease by the World Organization for Animal Health(OIE).Importantly,a ne-gative EP test is mandatory for animals participating in equestrian sports and the horse trade.It is estimated that 90%of the global horse population resides in EP-endemic areas.Many risk factors are associated with the infection rate,in-cluding animal species,age,gender,breed,activities,and environmental factors(Onyiche et al.,2019). 展开更多
关键词 HORSE EPIDEMIOLOGY LISTED
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