Background:The incidence of early-onset colorectal cancer(EOCRC)has increased globally since the early 1990s.Comprehensively examining the risk factors would be helpful for risk stratification and the development of p...Background:The incidence of early-onset colorectal cancer(EOCRC)has increased globally since the early 1990s.Comprehensively examining the risk factors would be helpful for risk stratification and the development of per-sonalized colorectal cancer screening strategies.Methods:We performed a prospective study of the Chinese population aged 30-50 years to identify potential risk factors during a median follow-up of 9.1 years.We compared the distribution of demographic characteris-tics,lifestyle factors,dietary habits,and medical history among 222 EOCRC cases and 87,833 normal controls.Multivariate adjusted Cox hazard models were used for estimating EOCRC risks of each risk factor.Results:Our final analyses indicated that participants with a higher body mass index(HR,1.04;95%CI:1.00,1.08),regular alcohol consumption(HR,1.69;95%CI:1.12,2.91),higher intake of fish(HR,1.64;95%CI:1.01,2.67),hypertension(HR,1.99;95%CI:1.04,3.81),diabetes(HR,2.20;95%CI:1.08,4.49),and first-degree relatives with cancer(HR,1.70;95%CI:1.23,2.36)were at higher risk of EOCRC.Conclusion:We identified several modifiable as well as nonmodifiable risk factors,such as higher BMI,alcohol and fish consumption,hypertension,and diabetes,were associated with EOCRC.展开更多
Polymeric ultralong organic phosphorescence(UOP)with persistent emission is of great importance in practical applications.However,achieving good water-resistance for long-term environmental stability is a formidable c...Polymeric ultralong organic phosphorescence(UOP)with persistent emission is of great importance in practical applications.However,achieving good water-resistance for long-term environmental stability is a formidable challenge.In this contribution,through tailoring the alkyl-chain length of the hardeners and emitters,polymeric UOPs with varying crosslinking density and hydrophobic effect were obtained.Notably,all the polymers show no obvious decrease in UOP emission after high temperature-humidity test(85℃/85%relative humidity for 7 days).Detailed investigations demonstrate that the rigid covalent crosslinking networks suppress the quenching of triplet excitons while the hydrophobic microenvironment affords good water/moisture-resistance ability.Moreover,the polymers with superior processability are successfully applied as optical coatings,prepreg,and afterglow displays.With this work,we provide a new strategy to promote the long-term stability of polymeric UOP materials in high-temperature-humidity conditions.展开更多
基金the CKB study staffs for kindly help to our project(DAR-2020-00106)supported by Guangdong Basic and Applied Basic Research Foundation(grant number:2020A1515110056)Guangzhou Municipal Science&Technology Planning(grant number:202102010172).
文摘Background:The incidence of early-onset colorectal cancer(EOCRC)has increased globally since the early 1990s.Comprehensively examining the risk factors would be helpful for risk stratification and the development of per-sonalized colorectal cancer screening strategies.Methods:We performed a prospective study of the Chinese population aged 30-50 years to identify potential risk factors during a median follow-up of 9.1 years.We compared the distribution of demographic characteris-tics,lifestyle factors,dietary habits,and medical history among 222 EOCRC cases and 87,833 normal controls.Multivariate adjusted Cox hazard models were used for estimating EOCRC risks of each risk factor.Results:Our final analyses indicated that participants with a higher body mass index(HR,1.04;95%CI:1.00,1.08),regular alcohol consumption(HR,1.69;95%CI:1.12,2.91),higher intake of fish(HR,1.64;95%CI:1.01,2.67),hypertension(HR,1.99;95%CI:1.04,3.81),diabetes(HR,2.20;95%CI:1.08,4.49),and first-degree relatives with cancer(HR,1.70;95%CI:1.23,2.36)were at higher risk of EOCRC.Conclusion:We identified several modifiable as well as nonmodifiable risk factors,such as higher BMI,alcohol and fish consumption,hypertension,and diabetes,were associated with EOCRC.
基金Key-Area Research and Development Program of Guangdong Province,Grant/Award Number:2023B0101030002Shenzhen R&D Project,Grant/Award Number:JSGGZD20220822100001002Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2022A1515110927。
文摘Polymeric ultralong organic phosphorescence(UOP)with persistent emission is of great importance in practical applications.However,achieving good water-resistance for long-term environmental stability is a formidable challenge.In this contribution,through tailoring the alkyl-chain length of the hardeners and emitters,polymeric UOPs with varying crosslinking density and hydrophobic effect were obtained.Notably,all the polymers show no obvious decrease in UOP emission after high temperature-humidity test(85℃/85%relative humidity for 7 days).Detailed investigations demonstrate that the rigid covalent crosslinking networks suppress the quenching of triplet excitons while the hydrophobic microenvironment affords good water/moisture-resistance ability.Moreover,the polymers with superior processability are successfully applied as optical coatings,prepreg,and afterglow displays.With this work,we provide a new strategy to promote the long-term stability of polymeric UOP materials in high-temperature-humidity conditions.
