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Acyldesilylation of 5-Trimethylsilyl-2-furancarboxaldehyde
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作者 Hu Ri PIAO zhe shan quan +1 位作者 Kouji NAKAYAMA Akira TANAKA(School of Pharmacy,Yanbian University,Yanji,133000)(Faculty of Pharmaceutical Sciences,Josai University,Saitama,Japan 350-02) 《Chinese Chemical Letters》 SCIE CAS CSCD 1999年第1期11-12,共2页
Acyldesilylation of 5-trimethylsilyl-2-furancarboxaldehyde with acyl chlorides was investigated and the unexpected 5-acyl-2-dichloromethylfuran were obtained as main products. The expected 5-acyl-2-furancarboxaldehyde... Acyldesilylation of 5-trimethylsilyl-2-furancarboxaldehyde with acyl chlorides was investigated and the unexpected 5-acyl-2-dichloromethylfuran were obtained as main products. The expected 5-acyl-2-furancarboxaldehydes were also found after hydrolyzing of the corresponding dichloro-compounds. 展开更多
关键词 2-acyl-5-dichloromethylfuran 5-acyl-2-furancarboxaldehyde 5-trimethyisilyl-2-furancarboxaldehyde acyldesilylation
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Synthesis and positive inotropic evaluation of 1-(benzylamino)-3-(4,5-di-hydro[1,2,4]trizaolo[4,3-a]quinolin-7-yloxy)propan-2-ol derivatives
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作者 Ting Ting Li Ling Zhang +2 位作者 zhe shan quan Hai Bo Zhu Hu Ri Piao 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第2期175-177,共3页
In an attempt to search for more potent positive inotropic agents, a series of 1-(benzylamino)-3-(4,5-dihydro[ 1,2,4]trizaolo[4,3- a]quinolin-7-yloxy)propan-2-ol derivatives was synthesized in four steps using 6-h... In an attempt to search for more potent positive inotropic agents, a series of 1-(benzylamino)-3-(4,5-dihydro[ 1,2,4]trizaolo[4,3- a]quinolin-7-yloxy)propan-2-ol derivatives was synthesized in four steps using 6-hydroxy-3,4-dihydro-2(1H)-quinolinone as a starting material, and their positive inotropic activities were evaluated by measuring the coronary blood flow (CBF) and the left ventricular pressure (LVP) followed by calculating the rate of pressure development (dp/dtmax values) in the preparation of rat Langendorff's heart. Three compounds (5d, 5g, 5j) showed favorable activities, among which 5g was shown the most potent with dp/dtmax value of 9.7% and CBF value of 17.8% at a concentration of 1×10^-5 mol/L in our in vitro study. 展开更多
关键词 3 4-Dihydro[1 2 4]trizaolo[4 3-a]quinoline Positive inotropic activity SYNTHESIS
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