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钯-手性磷酸接力催化的一锅三步串联反应合成手性四氢喹啉
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作者 梁仁校 钟哲 +2 位作者 金张灵 史丽娟 贾义霞 《大学化学》 CAS 2024年第5期209-217,共9页
设计钯-手性磷酸接力催化体系,以邻碘苯胺和苯基烯丙醇为原料,通过“一锅三步”串联反应高效合成手性2-苯基四氢喹啉,实验无需中间体分离,降低了手性四氢喹啉的合成难度并提高反应经济性,与单一催化反应相比,协同接力催化具有操作简单... 设计钯-手性磷酸接力催化体系,以邻碘苯胺和苯基烯丙醇为原料,通过“一锅三步”串联反应高效合成手性2-苯基四氢喹啉,实验无需中间体分离,降低了手性四氢喹啉的合成难度并提高反应经济性,与单一催化反应相比,协同接力催化具有操作简单、反应高效等优点。将协同接力催化的科学前沿引入本科实验教学,融入节能减排和绿色化学等课程思政元素,能拓宽学生的科学视野,激发其学习兴趣并提升创新能力。此外,实验涵盖格氏反应、Heck反应、亚胺缩合反应、不对称氢转移反应等理论知识以及薄层色谱、柱层析色谱、旋转蒸发仪、核磁共振仪、高效液相色谱仪、旋光仪等分析分离设备的操作使用,能综合提升学生的理论水平、实验技能和科学思维能力,促进科研与教学相融合。 展开更多
关键词 接力催化 串联反应 不对称合成 四氢喹啉
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Waking Up Brain with Electrical Stimulation to Boost Memory in Sleep:A Neuroscience Exploration
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作者 zhe zhong Fuling Yan Chunming Xie 《Neuroscience Bulletin》 SCIE CAS CSCD 2024年第6期852-854,共3页
Imagine that,in the future,you could enhance your memory by applying a mild electric current to your brain during sleep.This might sound like science fiction,but it is based on cutting-edge neuroscience research.Sleep... Imagine that,in the future,you could enhance your memory by applying a mild electric current to your brain during sleep.This might sound like science fiction,but it is based on cutting-edge neuroscience research.Sleep is widely recognized as a crucial factor for long-term memory consolidation,but the exact mechanisms by which the brain coordinates neural activity across different regions during sleep to reorganize and integrate memories are unknown[1,2]. 展开更多
关键词 SLEEP INTEGRATE APPLYING
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Thermal stability improvement of sprayable fast-responding pressure-sensitive paint for measurement above 100℃ 被引量:2
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作者 Di PENG Feng GU +1 位作者 zhe zhong Yingzheng LIU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2021年第1期320-326,共7页
The thermal stability of sprayable fast-responding Pressure-Sensitive Paint(fast PSP)was investigated to explore the possibility for application in turbomachinery and hypersonic research with temperature above 100℃.T... The thermal stability of sprayable fast-responding Pressure-Sensitive Paint(fast PSP)was investigated to explore the possibility for application in turbomachinery and hypersonic research with temperature above 100℃.The first part of the study focused on a widely-used Polymer Ceramic PSP(PC-PSP).The effects of thermal degradation on its key sensing properties,including luminescent intensity,pressure sensitivity and response time,were examined for a temperature range from 60 to 100℃.Severe degradation in intensity and pressure sensitivity was found as temperature reached 70℃or higher,which would cause failure of PSP application in these conditions.Subsequently,a fast-responding Mesoporous-Particle PSP(MP-PSP)was developed which did not show degradation effects until 140℃.The greatly improved thermal stability of MP-PSP was attributed to:selection of polymer with higher glass transition temperature(polystyrene)to delay the saturation effect of oxygen quenching as temperature increased;porous and hollow structure of particles for luminophore deposition that minimizes polymer–luminophore interaction.This new paint formulation has significantly raised the upper temperature limit of fast PSP and offers more opportunities for applications in harsh environment. 展开更多
关键词 Dynamic response Polymer–luminophore interaction Pressure sensitivity Pressure-sensitive paint Thermal degradation
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