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Application of mesenchymal stem cells as a vehicle to deliver replication-competent adenovirus for treating malignant glioma 被引量:3
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作者 Cui Hai Yong-Min Jin +6 位作者 Wen-Biao Jin zhe-zhu han Mei-Nv Cui Xue-Zhe Piao Xiong-Hu Shen Song-Nan Zhang Hong-Hua Sun 《Chinese Journal of Cancer》 SCIE CAS CSCD 2012年第5期233-240,共8页
Although gene therapy was regarded as a promising approach for glioma treatment,its therapeutic efficacy was often disappointing because of the lack of efficient drug delivery systems.Mesenchymal stem cells(MSCs) have... Although gene therapy was regarded as a promising approach for glioma treatment,its therapeutic efficacy was often disappointing because of the lack of efficient drug delivery systems.Mesenchymal stem cells(MSCs) have been reported to have a tropism for brain tumors and thus could be used as delivery vehicles for glioma therapy.Therefore,in this study,we attempted to treat glioma by using MSCs as a vehicle for delivering replication-competent adenovirus.We firstly compared the infectivity of type 3,type 5,and type 35 fiber-modified adenoviruses in MSCs.We also determined suitable adenovirus titer in vitro and then used this titer to analyze the ability of MSCs to deliver replication-competent adenovirus into glioma in vivo.Our results indicated that type 35 fiber-modified adenovirus showed higher infectivity than did naked type 3 or type 5 fiber-modified adenovirus.MSCs carrying replication-competent adenovirus significantly inhibited tumor growth in vivo compared with other control groups.In conclusion,MSCs are an effective vehicle that can successfully transport replication-competent adenovirus into glioma,making it a potential therapeutic strategy for treating malignant glioma. 展开更多
关键词 脑胶质瘤 病毒复制 间质干细胞 腺病毒 治疗 能力 骨髓间充质干细胞 车辆
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