With the advancement of new engineering construction,it is urgent to explore the teaching reform of professional courses in the cultivation of landscape architecture professionals in combination with industry needs.In...With the advancement of new engineering construction,it is urgent to explore the teaching reform of professional courses in the cultivation of landscape architecture professionals in combination with industry needs.In order to solve the problems existing in the current Landscape Engineering course,such as traditional teaching methods,insufficient student interest,lack of practical links,and the disconnection between teaching content and industry demand.This study discusses the teaching reform of the Landscape Engineering course based on the CDIO(Conceive-Design-Implement-Operate)concept,aiming at solving the problems mentioned.Through the integration of CDIO mode,the core competencies that students should have are defined,including environmental landscape design and planning,innovative thinking,project management,and so on.The research emphasizes project-driven learning,interdisciplinary knowledge integration,and practical skill training,and puts forward strategies such as teacher training and professional development support to ensure the implementation of the reform.The purpose of the reform was to improve students’professional ability and employment competitiveness,promote the improvement of education quality and the sustainable development of the industry,and exert a positive impact on landscape engineering education and industry progress.展开更多
Wooden buildings play a very important role in China’s construction and landscape architecture industry.In order to explore the weathering characteristics of the surface layer of landscape wooden buildings,the main c...Wooden buildings play a very important role in China’s construction and landscape architecture industry.In order to explore the weathering characteristics of the surface layer of landscape wooden buildings,the main causes of weathering were analyzed on the basis of summarizing the common types of weathering characterization.The results showed that the weathering characterization was mainly reflected in the surface defects of wood structures,such as cracking,discoloration,peeling,wind erosion wear,and so on.The coating technology on the surface of constructions was the main artificial factor affecting the surface defects of constructions.In the case of similar surface decoration conditions,sunlight and moisture were the main natural factors affecting the weathering of wooden buildings,which will promote the process of weathering.展开更多
Developing new high-entropy rare-earth zirconate(HE-RE_(2)Zr_(2)O_(7))ceramics with low thermal conductivity is essential for thermal barrier coating materials.In this work,the average atomic spacings,interatomic forc...Developing new high-entropy rare-earth zirconate(HE-RE_(2)Zr_(2)O_(7))ceramics with low thermal conductivity is essential for thermal barrier coating materials.In this work,the average atomic spacings,interatomic forces,and average atomic masses of 16 rare-earth elements occupying the A site of the cubic A_(2)B_(2)O_(7) crystal structure were calculated by density functional theory.These three physical qualities,as vectors,characterize the corresponding rare-earth elements.The distance between two vectors quantitatively describes the difference between two rare-earth elements.For greater differences between two rare-earth elements,the disorder degree of HE-RE_(2)Zr_(2)O_(7)is greater,and therefore,the thermal conductivity is lower.According to the theoretical calculations,the thermal conductivity of the ceramics gradually increases in the order of(SC_(0.2)Y_(0.2)La_(0.2)Ho_(0.2)Yb_(0.2))_(2)Zr_(2)0_(7),(SC_(0.2)Ce_(0.2)Nd_(0.2)Eu_(0.2)Gd_(0.2))_(2)Zr_(2)0_(7),(SC_(0.2)Y_(0.2)Tm_(0.2)Yb_(0.2)Lu_(0.2))_(2)Zr_(2)0_(7),and(Sc_(0.2)Er_(0.2)Tm_(0.2)Yb_(0.2)Lu_(0.2))_(2)Zr_(2)O_(7).Using the solution precursor plasma spray method and pressureless sintering method,four types of HE-RE2Zr2Oz powder and bulk samples were prepared.The samples all showed a single defective fluorite structure with a uniform distribution of the elements and a stable phase structure.The thermal conductivities of the sintered HE-RE_(2)Zr_(2)0_(7) bulk samples ranged from 1.30 to 1.45 Wm^(-1).K^(-1) at 1400℃,and their differences were consistent with the theoretical calculation results.Among the ceramics,(Sc_(0.2)Y_(0.2)La_(0.2)Ho_(0.2)Yb_(0.2))_(2)Zr_(2)O_(7) had the lowest thermal conductivity(1.30 W·m^(-1)·K^(-1),1400℃),highest thermal expansion coefficient(10.19×10^(-6) K^(-1),200-1400℃),highest fracture toughness(1.69±0.28 MPa·m^(1/2)),and smallest brttleness index(3.03μm^(1/2)).Therefore,(Sc_(0.2)Y_(0.2)La_(0.2)Ho_(0.2)Yb_(0.2))_(2)Zr_(2)0_(7)is considered to be an ideal candidate material for next-generation thermal barrier coating applications.展开更多
Ribonucleic acid(RNA)nanotechnology platforms have the potential of harboring therapeutics for in vivo delivery in disease treatment.However,the nonspecific interaction between the harbored hydrophobic drugs and cells...Ribonucleic acid(RNA)nanotechnology platforms have the potential of harboring therapeutics for in vivo delivery in disease treatment.However,the nonspecific interaction between the harbored hydrophobic drugs and cells or other components before reaching the diseased site has been an obstacle in drug delivery.Here we report an encapsulation strategy to prevent such nonspecific hydrophobic interactions in vitro and in vivo based on a self-assembled three-dimensional(3D)RNA nanocage.By placing an RNA three-way junction(3WJ)in the cavity of the nanocage,the conjugated hydrophobic molecules were specifically positioned within the nanocage,preventing their exposure to the biological environment.The assembly of the nanocages was characterized by native polyacrylamide gel electrophoresis(PAGE),atomic force microscopy(AFM),and cryogenic electron microscopy(cryo-EM)imaging.The stealth effect of the nanocage for hydrophobic molecules in vitro was evaluated by gel electrophoresis,flow cytometry,and confocal microscopy.The in vivo sheathing effect of the nanocage for hydrophobic molecules was assessed by biodistribution profiling in mice.The RNA nanocages with hydrophobic biomolecules underwent faster clearance in liver and spleen in comparison to their counterparts.Therefore,this encapsulation strategy holds promise for in vivo delivery of hydrophobic drugs for disease treatment.展开更多
基金The 2023 Inner Mongolia Agricultural University Offline First-Class Undergraduate Courses Project(Inner Agricultural University Education No.[2023]13,RC2400001250)。
文摘With the advancement of new engineering construction,it is urgent to explore the teaching reform of professional courses in the cultivation of landscape architecture professionals in combination with industry needs.In order to solve the problems existing in the current Landscape Engineering course,such as traditional teaching methods,insufficient student interest,lack of practical links,and the disconnection between teaching content and industry demand.This study discusses the teaching reform of the Landscape Engineering course based on the CDIO(Conceive-Design-Implement-Operate)concept,aiming at solving the problems mentioned.Through the integration of CDIO mode,the core competencies that students should have are defined,including environmental landscape design and planning,innovative thinking,project management,and so on.The research emphasizes project-driven learning,interdisciplinary knowledge integration,and practical skill training,and puts forward strategies such as teacher training and professional development support to ensure the implementation of the reform.The purpose of the reform was to improve students’professional ability and employment competitiveness,promote the improvement of education quality and the sustainable development of the industry,and exert a positive impact on landscape engineering education and industry progress.
基金Science and technology research projects of colleges and universities in Inner Mongolia(NJZY22511)Funds for basic scientific research in universities of Inner Mongolia:Key project of Philosophy and Social Science Foundation of Inner Mongolia Agricultural University(BR220603)。
文摘Wooden buildings play a very important role in China’s construction and landscape architecture industry.In order to explore the weathering characteristics of the surface layer of landscape wooden buildings,the main causes of weathering were analyzed on the basis of summarizing the common types of weathering characterization.The results showed that the weathering characterization was mainly reflected in the surface defects of wood structures,such as cracking,discoloration,peeling,wind erosion wear,and so on.The coating technology on the surface of constructions was the main artificial factor affecting the surface defects of constructions.In the case of similar surface decoration conditions,sunlight and moisture were the main natural factors affecting the weathering of wooden buildings,which will promote the process of weathering.
基金This work is supported by the National Natural Science Foundation of China(Nos.51865044,52062040)Science and Technology Projects of Inner Mongolia Autonomous Region(Nos.2021PT0008,2022ZD02,2022MS05003)Basic Scientific Research Expenses Program of Universities Directly under Inner Mongolia Autonomous Region(Nos.JY20220041,JY20220062).
文摘Developing new high-entropy rare-earth zirconate(HE-RE_(2)Zr_(2)O_(7))ceramics with low thermal conductivity is essential for thermal barrier coating materials.In this work,the average atomic spacings,interatomic forces,and average atomic masses of 16 rare-earth elements occupying the A site of the cubic A_(2)B_(2)O_(7) crystal structure were calculated by density functional theory.These three physical qualities,as vectors,characterize the corresponding rare-earth elements.The distance between two vectors quantitatively describes the difference between two rare-earth elements.For greater differences between two rare-earth elements,the disorder degree of HE-RE_(2)Zr_(2)O_(7)is greater,and therefore,the thermal conductivity is lower.According to the theoretical calculations,the thermal conductivity of the ceramics gradually increases in the order of(SC_(0.2)Y_(0.2)La_(0.2)Ho_(0.2)Yb_(0.2))_(2)Zr_(2)0_(7),(SC_(0.2)Ce_(0.2)Nd_(0.2)Eu_(0.2)Gd_(0.2))_(2)Zr_(2)0_(7),(SC_(0.2)Y_(0.2)Tm_(0.2)Yb_(0.2)Lu_(0.2))_(2)Zr_(2)0_(7),and(Sc_(0.2)Er_(0.2)Tm_(0.2)Yb_(0.2)Lu_(0.2))_(2)Zr_(2)O_(7).Using the solution precursor plasma spray method and pressureless sintering method,four types of HE-RE2Zr2Oz powder and bulk samples were prepared.The samples all showed a single defective fluorite structure with a uniform distribution of the elements and a stable phase structure.The thermal conductivities of the sintered HE-RE_(2)Zr_(2)0_(7) bulk samples ranged from 1.30 to 1.45 Wm^(-1).K^(-1) at 1400℃,and their differences were consistent with the theoretical calculation results.Among the ceramics,(Sc_(0.2)Y_(0.2)La_(0.2)Ho_(0.2)Yb_(0.2))_(2)Zr_(2)O_(7) had the lowest thermal conductivity(1.30 W·m^(-1)·K^(-1),1400℃),highest thermal expansion coefficient(10.19×10^(-6) K^(-1),200-1400℃),highest fracture toughness(1.69±0.28 MPa·m^(1/2)),and smallest brttleness index(3.03μm^(1/2)).Therefore,(Sc_(0.2)Y_(0.2)La_(0.2)Ho_(0.2)Yb_(0.2))_(2)Zr_(2)0_(7)is considered to be an ideal candidate material for next-generation thermal barrier coating applications.
基金The research in P.G.’s lab was supported by NIH grants(Nos.R01EB019036,U01CA151648,and U01CA207946)to Peixuan GuoThe cryo-EM work was supported by NIH grant No.5941GM103832(W.C.)and Office of Naval Research grant No.N00014-20-1-2084(W.C.).P.G.’s Sylvan G.Frank Endowed Chair position in Pharmaceutics and Drug Delivery is funded by the CM Chen Foundation.The authors would like to thank the Nanoimaging Core Facility at UNMC for assistance with AFM imaging.The facility is in part supported by funds received from the Nebraska Research Initiative(NRI).The animal study protocol was approved by the Institutional Animal Care and Use Committee at The Ohio State University.The authors would like to thank Alyssa Castillo for help in sample preparation.
文摘Ribonucleic acid(RNA)nanotechnology platforms have the potential of harboring therapeutics for in vivo delivery in disease treatment.However,the nonspecific interaction between the harbored hydrophobic drugs and cells or other components before reaching the diseased site has been an obstacle in drug delivery.Here we report an encapsulation strategy to prevent such nonspecific hydrophobic interactions in vitro and in vivo based on a self-assembled three-dimensional(3D)RNA nanocage.By placing an RNA three-way junction(3WJ)in the cavity of the nanocage,the conjugated hydrophobic molecules were specifically positioned within the nanocage,preventing their exposure to the biological environment.The assembly of the nanocages was characterized by native polyacrylamide gel electrophoresis(PAGE),atomic force microscopy(AFM),and cryogenic electron microscopy(cryo-EM)imaging.The stealth effect of the nanocage for hydrophobic molecules in vitro was evaluated by gel electrophoresis,flow cytometry,and confocal microscopy.The in vivo sheathing effect of the nanocage for hydrophobic molecules was assessed by biodistribution profiling in mice.The RNA nanocages with hydrophobic biomolecules underwent faster clearance in liver and spleen in comparison to their counterparts.Therefore,this encapsulation strategy holds promise for in vivo delivery of hydrophobic drugs for disease treatment.