BACKGROUND Childhood asthma is a common respiratory ailment that significantly affects preschool children.Effective asthma management in this population is particularly challenging due to limited communication skills ...BACKGROUND Childhood asthma is a common respiratory ailment that significantly affects preschool children.Effective asthma management in this population is particularly challenging due to limited communication skills in children and the necessity for consistent involvement of a caregiver.With the rise of digital healthcare and the need for innovative interventions,Internet-based models can potentially offer relatively more efficient and patient-tailored care,especially in children.AIM To explore the impact of an intelligent Internet care model based on the child respiratory and asthma control test(TRACK)on asthma management in preschool children.METHODS The study group comprised preschoolers,aged 5 years or younger,that visited the hospital's pediatric outpatient and emergency departments between January 2021 and January 2022.Total of 200 children were evenly and randomly divided into the observation and control groups.The control group received standard treatment in accordance with the 2016 Guidelines for Pediatric Bronchial Asthma and the Global Initiative on Asthma.In addition to above treatment,the observation group was introduced to an intelligent internet nursing model,emphasizing the TRACK scale.Key measures monitored over a six-month period included the frequency of asthma attack,emergency visits,pulmonary function parameters(FEV1,FEV1/FVC,and PEF),monthly TRACK scores,and the SF-12 quality of life assessment.Post-intervention asthma control rates were assessed at six-month follow-up.RESULTS The observation group had fewer asthma attacks and emergency room visits than the control group(P<0.05).After six months of treatment,the children in both groups had higher FEV1,FEV1/FVC,and PEF(P<0.05).Statistically significant differences were observed between the two groups(P<0.05).For six months,children in the observation group had a higher monthly TRACK score than those in the control group(P<0.05).The PCS and MCSSF-12 quality of life scores were relatively higher than those before the nursing period(P<0.05).Furthermore,the groups showed statistically significant differences(P<0.05).The asthma control rate was higher in the observation group than in the control group(P<0.05).CONCLUSION TRACK based Intelligent Internet nursing model may reduce asthma attacks and emergency visits in asthmatic children,improve lung function,quality of life,and the TRACK score and asthma control rate.The effect of nursing was significant,allowing for development of an asthma management model.展开更多
In the process of continuous maturity and development of medical imaging diagnosis,it is common to transmit images through public networks.How to ensure the security of transmission,cultivate talents who combine medic...In the process of continuous maturity and development of medical imaging diagnosis,it is common to transmit images through public networks.How to ensure the security of transmission,cultivate talents who combine medical imaging and information security,and explore and cultivate new discipline growth points are difficult problems and challenges for schools and educators.In order to cope with industrial changes,a new round of scientific and technological revolution,and the challenges of the further development of artificial intelligence in medicine,this article will analyze the existing problems in the training of postgraduates in medical imaging information security by combining the actual conditions and characteristics of universities,and put forward countermeasures and suggestions to promote the progress of technology in universities.展开更多
Osteomyelitis is a debilitating bone infection primarily caused by Staphylococcus aureus.Despite advancements in surgery and chemotherapy,the treatment of osteomyelitis remains unsatisfactory,characterized by antibiot...Osteomyelitis is a debilitating bone infection primarily caused by Staphylococcus aureus.Despite advancements in surgery and chemotherapy,the treatment of osteomyelitis remains unsatisfactory,characterized by antibiotic resistance and recurrent relapses.Numerous studies have confirmed that non-coding RNAs could play an emerging role in regulating gene expression,as well as in the differentiation of osteoblasts and osteoclasts,along with bone formation.In this context,we provide an overview of current knowledge regarding the roles of non-coding RNAs in osteomyelitis and explore the potential therapeutic applications of these molecules in disease management,aiming to uncover novel diagnostic and treatment approaches.展开更多
Cancer is a common cause of death worldwide.Despite significant advances in cancer treatments,the morbidity and mortality are still enormous.Tumor heterogeneity,especially intratumoral heterogeneity,is a significant r...Cancer is a common cause of death worldwide.Despite significant advances in cancer treatments,the morbidity and mortality are still enormous.Tumor heterogeneity,especially intratumoral heterogeneity,is a significant reason underlying difficulties in tumor treatment and failure of a number of current therapeutic modalities,even of molecularly targeted therapies.The development of a virtually noninvasive "liquid biopsy" from the blood has been attempted to characterize tumor heterogeneity.This review focuses on cell-free circulating tumor DNA(ctDNA) in the bloodstream as a versatile biomarker.ctDNA analysis is an evolving field with many new methods being developed and optimized to be able to successfully extract and analyze ctDNA,which has vast clinical applications.ctDNA has the potential to accurately genotype the tumor and identify personalized genetic and epigenetic alterations of the entire tumor.In addition,ctDNA has the potential to accurately monitor tumor burden and treatment response,while also being able to monitor minimal residual disease,reducing the need for harmful adjuvant chemotherapy and allowing more rapid detection of relapse.There are still many challenges that need to be overcome prior to this biomarker getting wide adoption in the clinical world,including optimization,standardization,and large multicenter trials.展开更多
Citation network is often used for academic recommendation. However, it is difficult to achieve high recommendation accuracy and low time complexity because it is often very large and sparse and different citations ha...Citation network is often used for academic recommendation. However, it is difficult to achieve high recommendation accuracy and low time complexity because it is often very large and sparse and different citations have different purposes. What's more, some citations include unreasonable information, such as in case of intentional self-citation. To improve the accuracy of citation network-based academic recommendation and reduce the time complexity, we propose an academic recommendation method for recommending authors and papers. In which, an author-paper bilayer citation network is built, then an enhanced topic model, Author Community Topic Time Model(ACTTM) is proposed to detect high quality author communities in the author layer, and a set of attributes are proposed to comprehensively depict the author/paper nodes in the bilayer citation network. Experimental results prove that the proposed ACTTM can detect high quality author communities and facilitate low time complexity, and the proposed academic recommendation method can effectively improve the recommendation accuracy.展开更多
Early Ordovician A-type granites in the northeastern(NE) Songnen Block NE China were studied to better understand the geodynamic settings in this region.This research presents new zircon U–Pb ages and wholerock geoch...Early Ordovician A-type granites in the northeastern(NE) Songnen Block NE China were studied to better understand the geodynamic settings in this region.This research presents new zircon U–Pb ages and wholerock geochemical data for the Early Ordovician granites in the NE Songnen Block. Zircon U–Pb dating indicates that the granite in the Cuibei, Hongxing, and Meixi areas in the NE Songnen Block formed in the Early Ordovician with ages of 471–479 Ma. The granites show geochemical characteristics of high SiO2 and K2 O compositions and low FeOT, MgO, CaO, and P2 O5 compositions. They belong to a high K calc-alkaline series and display a weak peraluminous featurPe with A/CNK values of 0.98–1.14. The rocks have aREE composition of 249.98–423.94 ppm,and are enriched in LREE with(La/Yb)Nvalues of2.87–9.87, and display obvious Eu anomalies(d Eu =0.01–0.29). Trace elements of the studied granites are characterized by enrichment in Rb, Th, U, Pb, Hf, and Sm,and depletion of Ba, Nb, Ta, and Sr. They display geochemical features of high Zr +Y + Nb+Ce values(324–795 ppm) and Ga/Al ratios consistent with A-type granites. Based on particular geochemical features, such as high Rb/Nb(7.98–24.19) and Y/Nb(1.07–3.43), the studied A-type granites can be further classified as an A2-type subgroup. This research indicates that the Early Ordovician A-type granites were formed by the partial melting of ancient crust in an extensional setting. Lower Sr/Y and(Ho/Yb)Nratios indicate that plagioclase and amphibole are residual in the source, and garnet is absent, implying that the magma was generated at low levels of pressure. By contrast, the contemporaneous granites in the SE Xing'an Block suggest a subduction-related tectonic setting, and its adakitic property indicates a thickened continental crust.We suggest that the Paleo-Asian Ocean plate between the Xing'an and Songnen blocks subducted northward during the Early Ordovician. Meanwhile, the NE Songnen Block was exposed to a passive continental margin tectonic setting.展开更多
The application of spray towers for CO_2 capture is a development trend in recent years. However, most of the previous jobs were conducted in a cylindrical tower by using a single spray nozzle, whose configuration and...The application of spray towers for CO_2 capture is a development trend in recent years. However, most of the previous jobs were conducted in a cylindrical tower by using a single spray nozzle, whose configuration and performance is not good enough for industrial application. To solve this problem, the present work proposed a diameter-varying spray tower and a new spray mode of dual-nozzle opposed impinging spray to enhance the heat and mass transfer of CO_2 absorption process. Experiments were performed to investigate the mass transfer performance (in terms of the CO_ 2 removal rate (η) and the overall mass transfer coefficient (K_Ga_e)) of the improved spray tower under various operating conditions. Experimental results showed that the liquid to gas ratio and mole ratio of MEA to CO_2 are major factors, which affect the absorption performance and the maximums of η and (K_Ga_e that are 94.0% and 0.574 kmol·m^(-3)·h^(-1)·kP a^(-1), respectively, under the experimental conditions. Furthermore, new correlations to predict the mass transfer coefficient of the proposed spray tower are developed in various CO_2 concentrations with a Pearson Correlation Coefficient over 90%.展开更多
OBJECTIVE Although it is generally believed that nicotine accounts for the beneficial effect of smoking on ulcerative colitis,the underlying mechanisms remain not well-understood.Our previous finding that nicotine inh...OBJECTIVE Although it is generally believed that nicotine accounts for the beneficial effect of smoking on ulcerative colitis,the underlying mechanisms remain not well-understood.Our previous finding that nicotine inhibits inflammatory responses through inducing miRNA-124 prompted us to ask whether the miRNA is involved in the protective action of nicotine on UC.METHODS Mi R-124 expression in colon tissues and cells was determined by q-PCR and in situ hybridization.The effect of miR-124 on protective role of nicotine in ulcerative colitis was evaluated in DSS-treated mice and IL-6-treated Caco-2 colon epithelial cells.Expression of p-STAT3/STAT3 was detected by immunohistochemistry and Western blot analysis.RESULTS miR-124 expression is upregulated in colon tissues from patients and DSS-induced colitis.Nicotine treatment further elevated miR-124 level in colon tissues of the mice,in infiltrated lymphocytes and epithelial cells,and augmented miR-124 expression in lymphocytes isolated from human ulcerative colon tissues.Administration of nicotine also reduced weight loss,improved DAI and decreased HE score in DSS-induced colitis.Moreover,knockdown of miR-124 in vivo significantly diminished the beneficial effect of nicotine,and in vitro on IL-6-treated Caco-2 colon epithelial cells.Further analysis indicated that nicotine inhibited STAT3 activation in vivo and in IL-6-treated Caco-2 colon epithelial cells and Jurkat human T lymphocytes,in whichmiR-124 knockdown led to increased activation of STAT3.CONCLUSION These data indicated that nicotine exerts its protective action in UC through inducing miR-124 and its effect on STAT3,suggesting that the miR-124/STAT3 system is a potential target for the therapeutic intervention of UC.展开更多
The group recommendation system is a viral requirement for the Internet service provider to provide recommendation services for all the users in a group. Due to the shared or different interests among users in the gro...The group recommendation system is a viral requirement for the Internet service provider to provide recommendation services for all the users in a group. Due to the shared or different interests among users in the group, it is difficult for traditional personal recommendation algorithms to predict items that can meet the requirements of all the users in the group. In this paper, a random group recommendation model is proposed to recommend the top K most appealing items for all the users in a random group. By analyzing item ratings of all the users in the group, the recommendation model can abstract the group as a virtual user. Then a personal recommendation algorithm is applied to suggest the top K most appealing items for the virtual user. And the preference score and fuzzy clustering algorithm based on multiclass are applied to optimize the recommendation result of the group recommendation model. Finally, the Movie Lens-100 K dataset is applied to verify the efficiency of the recommendation model. The experimental results show that the items recommended by the proposed group recommendation model are more popular for all the users in the group than the items recommended by traditional group recommendation algorithms.展开更多
OBJECTIVE Although it is generally believed that nicotine accounts for the beneficial effect of smoking on ulcerative colitis,the underlying mechanisms remain not well understood.Our previous finding that nicotine inh...OBJECTIVE Although it is generally believed that nicotine accounts for the beneficial effect of smoking on ulcerative colitis,the underlying mechanisms remain not well understood.Our previous finding that nicotine inhibits inflammatory responses through inducing miRNA-124 prompted us to ask whether the miRNA is involved in the protective action of nicotine on UC.METHODS MiR-124 expres.sion in colon tissues and cells was determined by q-PCR and in situ hybridization.The effect of miR-124 on protective role of nicotine in ulcerative colitis was evaluated in DSS-treated mice and IL-6-treated Caco-2 colon epithelial cells.Expression of p-STAT3/STAT3 was detected by immunohistochemistry and Western-blot analysis.RESULTS miR-124 expression is upregulated in colon tissues from UC patients and DSS-induced colitis mice.Nicotine treatment further elevated miR-124 level in lympho.cytes isolated from human ulcerative colonic mucosa and ulcerative colon tissues from DSS mice,both in infiltrated lymphocytes and epithelial cells.Administration of nicotine also reduced weight loss,improved DAI and decreased HE score in DSS-induced colitis mice.Moreover,knockdown of miR-124 in vivo significantly diminished the beneficial effect of nicotine on murine colitis,and in vitro on IL-6-treated Caco-2 colon epithelial cells.Further analysis indicated that nicotine inhibited STAT3 activation in vivo and in IL-6-treated Caco-2 colon epithelial cells and Jurkat human T lymphocytes,in which miR-124 knockdown led to increased activation of STAT3.Blocking STAT3 activity alone is beneficial for DSS colitis and also abolished nicotine′s protective effect in this model.CONCLUSION These data indicated that nicotine exerts its protective action in UC through inducing miR-124 and its effect on STAT3,and suggest that the miR-124/STAT3 system is a potential target for the therapeutic intervention of UC.展开更多
In recent years,miR-124 has emerged as a critical modulator of immunity and inflammation.Here,we summarize studies on the function and mechanism of miR-124 in the immune system and immunity-related diseases.They indic...In recent years,miR-124 has emerged as a critical modulator of immunity and inflammation.Here,we summarize studies on the function and mechanism of miR-124 in the immune system and immunity-related diseases.They indicated that miR-124 exerts a crucial role in the development of immune system,regulation of immune responses,and inflammatory disorders.It is evident that miR-124 may serve as an informative diagnostic biomarker and therapeutic target in the future.展开更多
In modern medicine,medical image examination has become an important method and tool to deal with clinical diseases.The inherent defects of artificial analysis of medical images make medical images become the most val...In modern medicine,medical image examination has become an important method and tool to deal with clinical diseases.The inherent defects of artificial analysis of medical images make medical images become the most valuable application scenario of artificial intelligence(AI).This paper aims at how to effectively adapt to economic development and cultivate talents who combine artificial intelligence and medicine,which is a difficult problem and challenge facing schools and educators.A new AI+medical imaging talent training model was proposed,and suggestions for improvement were introduced from the course design,assessment system,faculty team,and course textbooks,and the teaching effect was explained through the training process,supporting conditions,and training mechanism,so as to promote the scientific and technological progress of colleges and universities.and development.展开更多
As an important part of the new generation of information technology,the Internet of Things(IoT)has been widely concerned and regarded as an enabling technology of the next generation of health care system.The fundus ...As an important part of the new generation of information technology,the Internet of Things(IoT)has been widely concerned and regarded as an enabling technology of the next generation of health care system.The fundus photography equipment is connected to the cloud platform through the IoT,so as to realize the realtime uploading of fundus images and the rapid issuance of diagnostic suggestions by artificial intelligence.At the same time,important security and privacy issues have emerged.The data uploaded to the cloud platform involves more personal attributes,health status and medical application data of patients.Once leaked,abused or improperly disclosed,personal information security will be violated.Therefore,it is important to address the security and privacy issues of massive medical and healthcare equipment connecting to the infrastructure of IoT healthcare and health systems.To meet this challenge,we propose MIA-UNet,a multi-scale iterative aggregation U-network,which aims to achieve accurate and efficient retinal vessel segmentation for ophthalmic auxiliary diagnosis while ensuring that the network has low computational complexity to adapt to mobile terminals.In this way,users do not need to upload the data to the cloud platform,and can analyze and process the fundus images on their own mobile terminals,thus eliminating the leakage of personal information.Specifically,the interconnection between encoder and decoder,as well as the internal connection between decoder subnetworks in classic U-Net are redefined and redesigned.Furthermore,we propose a hybrid loss function to smooth the gradient and deal with the imbalance between foreground and background.Compared with the UNet,the segmentation performance of the proposed network is significantly improved on the premise that the number of parameters is only increased by 2%.When applied to three publicly available datasets:DRIVE,STARE and CHASE DB1,the proposed network achieves the accuracy/F1-score of 96.33%/84.34%,97.12%/83.17%and 97.06%/84.10%,respectively.The experimental results show that the MIA-UNet is superior to the state-of-the-art methods.展开更多
With the proliferation of small and mini drones, Drone Small Cells(DSCs) can cooperative multiple drones to provide communication service for ground users as emergency means or supplementary ones of traditional terres...With the proliferation of small and mini drones, Drone Small Cells(DSCs) can cooperative multiple drones to provide communication service for ground users as emergency means or supplementary ones of traditional terrestrial cellular networks. In this paper, we study the fundamental problem of optimizing the deployment density of DSCs to achieve the maximum coverage performance. Most related works do not consider cumulative inter-cell interference when studying the coverage performance of DSCs. First, we derive an approximate and closed-form expression of the cumulative inter-cell interference which comes from both probabilistic Line-of-Sight(Lo S) and Non-Line-of-Sight(NLo S) links. Then, we analyze the coverage performance of DSCs and derive the transcendental function of optimal deployment density to obtain the maximum coverage. Last, we propose an algorithm to get the optimal deployment density with low complexity. We conduct both field experiments and Matlab simulations to verify the correctness of theoretical analysis. In addition, we show the impact of some factors on the relation between the deployment density and coverage performance through extensive numerical simulations.展开更多
Heart failure has become a global public health problem that seriously threatens human health.Due to "multi-target" effect,traditional Chinese medicine has unique advantages in the treat.ment of heart failur...Heart failure has become a global public health problem that seriously threatens human health.Due to "multi-target" effect,traditional Chinese medicine has unique advantages in the treat.ment of heart failure.Astragaloside Ⅳ is one of the main active ingredients of astragalus membrana.ceus.It has the functions of protecting the heart and neovascularization,anti-inflammation,anti-oxida.tion,regulating energy metabolism,neuroprotection and anti-cancer effects.This article reviews the recent progresses of astragaloside Ⅳ in the treatment of heart failure.Data show that astragaloside Ⅳ can inhibit heart fibrosis,attenuate excessively activation of renin-angiotensin system,increase energy metabolism,promote positive inotropic action,inhibit myocardial cell apoptosis,etc,which are all involved in the protective role of astragalosideⅣ in rodents or cellular models of heart failure.Astragalo.side Ⅳ may be a potential active ingredient in traditional Chinese medicine for the treatment of heart failure.展开更多
The slogan of“Combination of medicine and engineering”proposed in“Made in China 2025”has aroused great attention to higher engineering education.However,it is a difficult problem and challenge for schools and educ...The slogan of“Combination of medicine and engineering”proposed in“Made in China 2025”has aroused great attention to higher engineering education.However,it is a difficult problem and challenge for schools and educators to effectively adapt to the economic and social development,train new medical and engineering talents,and explore and cultivate new subject growth points.In order to deal with engineering change and a new round of scientific and technological revolution,facing the challenge of new engineering construction.This paper will combine the reality and characteristics of colleges and universities,analyze the problems existing in the current medical engineering cross-graduate training,and put forward countermeasures and suggestions to promote the progress and development of science and technology in colleges and universities.展开更多
基金Supported by Science and Technology Research Project of Songjiang District,No.2020SJ340.
文摘BACKGROUND Childhood asthma is a common respiratory ailment that significantly affects preschool children.Effective asthma management in this population is particularly challenging due to limited communication skills in children and the necessity for consistent involvement of a caregiver.With the rise of digital healthcare and the need for innovative interventions,Internet-based models can potentially offer relatively more efficient and patient-tailored care,especially in children.AIM To explore the impact of an intelligent Internet care model based on the child respiratory and asthma control test(TRACK)on asthma management in preschool children.METHODS The study group comprised preschoolers,aged 5 years or younger,that visited the hospital's pediatric outpatient and emergency departments between January 2021 and January 2022.Total of 200 children were evenly and randomly divided into the observation and control groups.The control group received standard treatment in accordance with the 2016 Guidelines for Pediatric Bronchial Asthma and the Global Initiative on Asthma.In addition to above treatment,the observation group was introduced to an intelligent internet nursing model,emphasizing the TRACK scale.Key measures monitored over a six-month period included the frequency of asthma attack,emergency visits,pulmonary function parameters(FEV1,FEV1/FVC,and PEF),monthly TRACK scores,and the SF-12 quality of life assessment.Post-intervention asthma control rates were assessed at six-month follow-up.RESULTS The observation group had fewer asthma attacks and emergency room visits than the control group(P<0.05).After six months of treatment,the children in both groups had higher FEV1,FEV1/FVC,and PEF(P<0.05).Statistically significant differences were observed between the two groups(P<0.05).For six months,children in the observation group had a higher monthly TRACK score than those in the control group(P<0.05).The PCS and MCSSF-12 quality of life scores were relatively higher than those before the nursing period(P<0.05).Furthermore,the groups showed statistically significant differences(P<0.05).The asthma control rate was higher in the observation group than in the control group(P<0.05).CONCLUSION TRACK based Intelligent Internet nursing model may reduce asthma attacks and emergency visits in asthmatic children,improve lung function,quality of life,and the TRACK score and asthma control rate.The effect of nursing was significant,allowing for development of an asthma management model.
文摘In the process of continuous maturity and development of medical imaging diagnosis,it is common to transmit images through public networks.How to ensure the security of transmission,cultivate talents who combine medical imaging and information security,and explore and cultivate new discipline growth points are difficult problems and challenges for schools and educators.In order to cope with industrial changes,a new round of scientific and technological revolution,and the challenges of the further development of artificial intelligence in medicine,this article will analyze the existing problems in the training of postgraduates in medical imaging information security by combining the actual conditions and characteristics of universities,and put forward countermeasures and suggestions to promote the progress of technology in universities.
基金supported by National Natural Science Foundation of China(32271177,82003981 to ZQ)President Fund of the 960th Hospital of Joint Logistics Support Force(2017ZX05 to C-LS).
文摘Osteomyelitis is a debilitating bone infection primarily caused by Staphylococcus aureus.Despite advancements in surgery and chemotherapy,the treatment of osteomyelitis remains unsatisfactory,characterized by antibiotic resistance and recurrent relapses.Numerous studies have confirmed that non-coding RNAs could play an emerging role in regulating gene expression,as well as in the differentiation of osteoblasts and osteoclasts,along with bone formation.In this context,we provide an overview of current knowledge regarding the roles of non-coding RNAs in osteomyelitis and explore the potential therapeutic applications of these molecules in disease management,aiming to uncover novel diagnostic and treatment approaches.
基金supported partly by the National Natural Science Foundation of China(No.81227901)the Natural Science Basic Research Plan in Shaanxi Province of China(No.2015JZ019)+1 种基金the Fundamental Research Funds for the Central Universities,National Cancer Institute of the National Institutes of Health(No.R00CA138914)National Natural Science Foundation(No. 81372216)
文摘Cancer is a common cause of death worldwide.Despite significant advances in cancer treatments,the morbidity and mortality are still enormous.Tumor heterogeneity,especially intratumoral heterogeneity,is a significant reason underlying difficulties in tumor treatment and failure of a number of current therapeutic modalities,even of molecularly targeted therapies.The development of a virtually noninvasive "liquid biopsy" from the blood has been attempted to characterize tumor heterogeneity.This review focuses on cell-free circulating tumor DNA(ctDNA) in the bloodstream as a versatile biomarker.ctDNA analysis is an evolving field with many new methods being developed and optimized to be able to successfully extract and analyze ctDNA,which has vast clinical applications.ctDNA has the potential to accurately genotype the tumor and identify personalized genetic and epigenetic alterations of the entire tumor.In addition,ctDNA has the potential to accurately monitor tumor burden and treatment response,while also being able to monitor minimal residual disease,reducing the need for harmful adjuvant chemotherapy and allowing more rapid detection of relapse.There are still many challenges that need to be overcome prior to this biomarker getting wide adoption in the clinical world,including optimization,standardization,and large multicenter trials.
基金supported by the grants from Natural Science Foundation of China (Project No.61471060)
文摘Citation network is often used for academic recommendation. However, it is difficult to achieve high recommendation accuracy and low time complexity because it is often very large and sparse and different citations have different purposes. What's more, some citations include unreasonable information, such as in case of intentional self-citation. To improve the accuracy of citation network-based academic recommendation and reduce the time complexity, we propose an academic recommendation method for recommending authors and papers. In which, an author-paper bilayer citation network is built, then an enhanced topic model, Author Community Topic Time Model(ACTTM) is proposed to detect high quality author communities in the author layer, and a set of attributes are proposed to comprehensively depict the author/paper nodes in the bilayer citation network. Experimental results prove that the proposed ACTTM can detect high quality author communities and facilitate low time complexity, and the proposed academic recommendation method can effectively improve the recommendation accuracy.
基金supported by the research program of Heilongjiang province (Nos. SDKC2017030 and HDKK201701)
文摘Early Ordovician A-type granites in the northeastern(NE) Songnen Block NE China were studied to better understand the geodynamic settings in this region.This research presents new zircon U–Pb ages and wholerock geochemical data for the Early Ordovician granites in the NE Songnen Block. Zircon U–Pb dating indicates that the granite in the Cuibei, Hongxing, and Meixi areas in the NE Songnen Block formed in the Early Ordovician with ages of 471–479 Ma. The granites show geochemical characteristics of high SiO2 and K2 O compositions and low FeOT, MgO, CaO, and P2 O5 compositions. They belong to a high K calc-alkaline series and display a weak peraluminous featurPe with A/CNK values of 0.98–1.14. The rocks have aREE composition of 249.98–423.94 ppm,and are enriched in LREE with(La/Yb)Nvalues of2.87–9.87, and display obvious Eu anomalies(d Eu =0.01–0.29). Trace elements of the studied granites are characterized by enrichment in Rb, Th, U, Pb, Hf, and Sm,and depletion of Ba, Nb, Ta, and Sr. They display geochemical features of high Zr +Y + Nb+Ce values(324–795 ppm) and Ga/Al ratios consistent with A-type granites. Based on particular geochemical features, such as high Rb/Nb(7.98–24.19) and Y/Nb(1.07–3.43), the studied A-type granites can be further classified as an A2-type subgroup. This research indicates that the Early Ordovician A-type granites were formed by the partial melting of ancient crust in an extensional setting. Lower Sr/Y and(Ho/Yb)Nratios indicate that plagioclase and amphibole are residual in the source, and garnet is absent, implying that the magma was generated at low levels of pressure. By contrast, the contemporaneous granites in the SE Xing'an Block suggest a subduction-related tectonic setting, and its adakitic property indicates a thickened continental crust.We suggest that the Paleo-Asian Ocean plate between the Xing'an and Songnen blocks subducted northward during the Early Ordovician. Meanwhile, the NE Songnen Block was exposed to a passive continental margin tectonic setting.
基金Supported by the National Natural Science Foundation of China(51276141)the Natural Science Basic Research Plan in Shaanxi Province of China(2015JQ5192)"Fundamental Research Funds for the Central Universities"
文摘The application of spray towers for CO_2 capture is a development trend in recent years. However, most of the previous jobs were conducted in a cylindrical tower by using a single spray nozzle, whose configuration and performance is not good enough for industrial application. To solve this problem, the present work proposed a diameter-varying spray tower and a new spray mode of dual-nozzle opposed impinging spray to enhance the heat and mass transfer of CO_2 absorption process. Experiments were performed to investigate the mass transfer performance (in terms of the CO_ 2 removal rate (η) and the overall mass transfer coefficient (K_Ga_e)) of the improved spray tower under various operating conditions. Experimental results showed that the liquid to gas ratio and mole ratio of MEA to CO_2 are major factors, which affect the absorption performance and the maximums of η and (K_Ga_e that are 94.0% and 0.574 kmol·m^(-3)·h^(-1)·kP a^(-1), respectively, under the experimental conditions. Furthermore, new correlations to predict the mass transfer coefficient of the proposed spray tower are developed in various CO_2 concentrations with a Pearson Correlation Coefficient over 90%.
基金supported by National Natural Science Foundation of China(81273606,81473259 to XL,81603116 to YS)National Science and Technology Major Project(2014ZX09J14103-08C to XL)
文摘OBJECTIVE Although it is generally believed that nicotine accounts for the beneficial effect of smoking on ulcerative colitis,the underlying mechanisms remain not well-understood.Our previous finding that nicotine inhibits inflammatory responses through inducing miRNA-124 prompted us to ask whether the miRNA is involved in the protective action of nicotine on UC.METHODS Mi R-124 expression in colon tissues and cells was determined by q-PCR and in situ hybridization.The effect of miR-124 on protective role of nicotine in ulcerative colitis was evaluated in DSS-treated mice and IL-6-treated Caco-2 colon epithelial cells.Expression of p-STAT3/STAT3 was detected by immunohistochemistry and Western blot analysis.RESULTS miR-124 expression is upregulated in colon tissues from patients and DSS-induced colitis.Nicotine treatment further elevated miR-124 level in colon tissues of the mice,in infiltrated lymphocytes and epithelial cells,and augmented miR-124 expression in lymphocytes isolated from human ulcerative colon tissues.Administration of nicotine also reduced weight loss,improved DAI and decreased HE score in DSS-induced colitis.Moreover,knockdown of miR-124 in vivo significantly diminished the beneficial effect of nicotine,and in vitro on IL-6-treated Caco-2 colon epithelial cells.Further analysis indicated that nicotine inhibited STAT3 activation in vivo and in IL-6-treated Caco-2 colon epithelial cells and Jurkat human T lymphocytes,in whichmiR-124 knockdown led to increased activation of STAT3.CONCLUSION These data indicated that nicotine exerts its protective action in UC through inducing miR-124 and its effect on STAT3,suggesting that the miR-124/STAT3 system is a potential target for the therapeutic intervention of UC.
基金supported in part by the National Natural Science Foundation of China under Grants No.61672135,No.61502085,No.61272527,and No.61370026the National High Technology Research and Development Program of China under Grant No.2015AA016007the Sichuan Science-Technology Support Plan Program under Grants No.2014GZ0106,No.2015GZ0095,and No.2016JZ0020。
文摘The group recommendation system is a viral requirement for the Internet service provider to provide recommendation services for all the users in a group. Due to the shared or different interests among users in the group, it is difficult for traditional personal recommendation algorithms to predict items that can meet the requirements of all the users in the group. In this paper, a random group recommendation model is proposed to recommend the top K most appealing items for all the users in a random group. By analyzing item ratings of all the users in the group, the recommendation model can abstract the group as a virtual user. Then a personal recommendation algorithm is applied to suggest the top K most appealing items for the virtual user. And the preference score and fuzzy clustering algorithm based on multiclass are applied to optimize the recommendation result of the group recommendation model. Finally, the Movie Lens-100 K dataset is applied to verify the efficiency of the recommendation model. The experimental results show that the items recommended by the proposed group recommendation model are more popular for all the users in the group than the items recommended by traditional group recommendation algorithms.
基金supported by National Natural Science Foundation of China(8147325981603116)
文摘OBJECTIVE Although it is generally believed that nicotine accounts for the beneficial effect of smoking on ulcerative colitis,the underlying mechanisms remain not well understood.Our previous finding that nicotine inhibits inflammatory responses through inducing miRNA-124 prompted us to ask whether the miRNA is involved in the protective action of nicotine on UC.METHODS MiR-124 expres.sion in colon tissues and cells was determined by q-PCR and in situ hybridization.The effect of miR-124 on protective role of nicotine in ulcerative colitis was evaluated in DSS-treated mice and IL-6-treated Caco-2 colon epithelial cells.Expression of p-STAT3/STAT3 was detected by immunohistochemistry and Western-blot analysis.RESULTS miR-124 expression is upregulated in colon tissues from UC patients and DSS-induced colitis mice.Nicotine treatment further elevated miR-124 level in lympho.cytes isolated from human ulcerative colonic mucosa and ulcerative colon tissues from DSS mice,both in infiltrated lymphocytes and epithelial cells.Administration of nicotine also reduced weight loss,improved DAI and decreased HE score in DSS-induced colitis mice.Moreover,knockdown of miR-124 in vivo significantly diminished the beneficial effect of nicotine on murine colitis,and in vitro on IL-6-treated Caco-2 colon epithelial cells.Further analysis indicated that nicotine inhibited STAT3 activation in vivo and in IL-6-treated Caco-2 colon epithelial cells and Jurkat human T lymphocytes,in which miR-124 knockdown led to increased activation of STAT3.Blocking STAT3 activity alone is beneficial for DSS colitis and also abolished nicotine′s protective effect in this model.CONCLUSION These data indicated that nicotine exerts its protective action in UC through inducing miR-124 and its effect on STAT3,and suggest that the miR-124/STAT3 system is a potential target for the therapeutic intervention of UC.
基金supported by National Natural Science Foundation of China(grant number 81273606,81473259 to XL,81603116 to YS)National Science and Technology Major Project(grant number 2014ZX09J14103-08C to XL)
文摘In recent years,miR-124 has emerged as a critical modulator of immunity and inflammation.Here,we summarize studies on the function and mechanism of miR-124 in the immune system and immunity-related diseases.They indicated that miR-124 exerts a crucial role in the development of immune system,regulation of immune responses,and inflammatory disorders.It is evident that miR-124 may serve as an informative diagnostic biomarker and therapeutic target in the future.
文摘In modern medicine,medical image examination has become an important method and tool to deal with clinical diseases.The inherent defects of artificial analysis of medical images make medical images become the most valuable application scenario of artificial intelligence(AI).This paper aims at how to effectively adapt to economic development and cultivate talents who combine artificial intelligence and medicine,which is a difficult problem and challenge facing schools and educators.A new AI+medical imaging talent training model was proposed,and suggestions for improvement were introduced from the course design,assessment system,faculty team,and course textbooks,and the teaching effect was explained through the training process,supporting conditions,and training mechanism,so as to promote the scientific and technological progress of colleges and universities.and development.
基金This work was supported in part by the National Natural Science Foundation of China(Nos.62072074,62076054,62027827,61902054)the Frontier Science and Technology Innovation Projects of National Key R&D Program(No.2019QY1405)+2 种基金the Sichuan Science and Technology Innovation Platform and Talent Plan(No.2020JDJQ0020)the Sichuan Science and Technology Support Plan(No.2020YFSY0010)the Natural Science Foundation of Guangdong Province(No.2018A030313354).
文摘As an important part of the new generation of information technology,the Internet of Things(IoT)has been widely concerned and regarded as an enabling technology of the next generation of health care system.The fundus photography equipment is connected to the cloud platform through the IoT,so as to realize the realtime uploading of fundus images and the rapid issuance of diagnostic suggestions by artificial intelligence.At the same time,important security and privacy issues have emerged.The data uploaded to the cloud platform involves more personal attributes,health status and medical application data of patients.Once leaked,abused or improperly disclosed,personal information security will be violated.Therefore,it is important to address the security and privacy issues of massive medical and healthcare equipment connecting to the infrastructure of IoT healthcare and health systems.To meet this challenge,we propose MIA-UNet,a multi-scale iterative aggregation U-network,which aims to achieve accurate and efficient retinal vessel segmentation for ophthalmic auxiliary diagnosis while ensuring that the network has low computational complexity to adapt to mobile terminals.In this way,users do not need to upload the data to the cloud platform,and can analyze and process the fundus images on their own mobile terminals,thus eliminating the leakage of personal information.Specifically,the interconnection between encoder and decoder,as well as the internal connection between decoder subnetworks in classic U-Net are redefined and redesigned.Furthermore,we propose a hybrid loss function to smooth the gradient and deal with the imbalance between foreground and background.Compared with the UNet,the segmentation performance of the proposed network is significantly improved on the premise that the number of parameters is only increased by 2%.When applied to three publicly available datasets:DRIVE,STARE and CHASE DB1,the proposed network achieves the accuracy/F1-score of 96.33%/84.34%,97.12%/83.17%and 97.06%/84.10%,respectively.The experimental results show that the MIA-UNet is superior to the state-of-the-art methods.
基金supported in part by National NSF of China under Grant No.61472445,No.61631020,No.61702525 and No.61702545in part by the NSF of Jiangsu Province under Grant No.BK20140076.5
文摘With the proliferation of small and mini drones, Drone Small Cells(DSCs) can cooperative multiple drones to provide communication service for ground users as emergency means or supplementary ones of traditional terrestrial cellular networks. In this paper, we study the fundamental problem of optimizing the deployment density of DSCs to achieve the maximum coverage performance. Most related works do not consider cumulative inter-cell interference when studying the coverage performance of DSCs. First, we derive an approximate and closed-form expression of the cumulative inter-cell interference which comes from both probabilistic Line-of-Sight(Lo S) and Non-Line-of-Sight(NLo S) links. Then, we analyze the coverage performance of DSCs and derive the transcendental function of optimal deployment density to obtain the maximum coverage. Last, we propose an algorithm to get the optimal deployment density with low complexity. We conduct both field experiments and Matlab simulations to verify the correctness of theoretical analysis. In addition, we show the impact of some factors on the relation between the deployment density and coverage performance through extensive numerical simulations.
文摘Heart failure has become a global public health problem that seriously threatens human health.Due to "multi-target" effect,traditional Chinese medicine has unique advantages in the treat.ment of heart failure.Astragaloside Ⅳ is one of the main active ingredients of astragalus membrana.ceus.It has the functions of protecting the heart and neovascularization,anti-inflammation,anti-oxida.tion,regulating energy metabolism,neuroprotection and anti-cancer effects.This article reviews the recent progresses of astragaloside Ⅳ in the treatment of heart failure.Data show that astragaloside Ⅳ can inhibit heart fibrosis,attenuate excessively activation of renin-angiotensin system,increase energy metabolism,promote positive inotropic action,inhibit myocardial cell apoptosis,etc,which are all involved in the protective role of astragalosideⅣ in rodents or cellular models of heart failure.Astragalo.side Ⅳ may be a potential active ingredient in traditional Chinese medicine for the treatment of heart failure.
文摘The slogan of“Combination of medicine and engineering”proposed in“Made in China 2025”has aroused great attention to higher engineering education.However,it is a difficult problem and challenge for schools and educators to effectively adapt to the economic and social development,train new medical and engineering talents,and explore and cultivate new subject growth points.In order to deal with engineering change and a new round of scientific and technological revolution,facing the challenge of new engineering construction.This paper will combine the reality and characteristics of colleges and universities,analyze the problems existing in the current medical engineering cross-graduate training,and put forward countermeasures and suggestions to promote the progress and development of science and technology in colleges and universities.
