Copper nanowires(Cu NWs)are considered an excellent alternative to indium tin oxide(ITO)in flexible transparency electrodes(FTEs).However,the mixed particles and surface oxidation of Cu NWs degrade the transmittance a...Copper nanowires(Cu NWs)are considered an excellent alternative to indium tin oxide(ITO)in flexible transparency electrodes(FTEs).However,the mixed particles and surface oxidation of Cu NWs degrade the transmittance and conductivity of the electrodes.Therefore,highly purified Cu NWs without oxidation are vital for high-performance FTEs.Herein,a facile and effective purification process is introduced to purify Cu NWs in a water and n-hexane system,which takes advantage of the differences in hydrophilicity between Cu NWs and Cu NPs caused by their different adsorption affinities to octadecylamine(ODA).At the same sheet resistance,the transmittance of the purified Cu NW-based FTEs improved approximately 2%compared to that of non-purified Cu NW-based FTEs.Immersion of the electrode in glacial acetic acid removed the surface organics and oxides.After only 40 s of treatment,the sheet resistance dramatically decreased from 10^5 Ohm/sq to 31 Ohm/sq with a transmittance of 85%.In addition,the Cu NW-based FTE conductors showed excellent flexibility(remaining stable after 1000 bending cycles).The Cu NW-based FTEs were further applied to fabricate a flexible transparent heater.At a voltage of 10 V,the temperature of the heater reached 73℃,demonstrating the potential applications of this material in various fields.展开更多
The Qiman Tagh W-Sn belt lies in the westernmost section of the East Kunlun Orogen, NW China, and is associated with early Paleozoic monzogranites, tourmaline is present throughout this belt. In this paper we report c...The Qiman Tagh W-Sn belt lies in the westernmost section of the East Kunlun Orogen, NW China, and is associated with early Paleozoic monzogranites, tourmaline is present throughout this belt. In this paper we report chemical and boron isotopic compositions of tourmaline from wall rocks, monzogranites, and quartz veins within the belt, for studying the evolution of ore-forming fluids. Tourmaline crystals hosted in the monzogranite and wall rocks belong to the alkali group, while those hosted in quartz veins belong to both the alkali and X-site vacancy groups. Tourmaline in the walk rocks lies within the schorl-dravite series and becomes increasingly schorlitic in the monzogranite and quartz veins. Detrital tourmaline in the wall rocks is commonly both optically and chemically zoned,with cores being enriched in Mg compared with the rims. In the Al-Fe-Mg and Ca-Fe-Mg diagrams,tourmaline from the wall rocks plots in the fields of Al-saturated and Ca-poor metapelite, and extends into the field of Li-poor granites, while those from the monzogranite and quartz veins lie within the field of Li-poor granites. Compositional substitution is best represented by the MgFe_(-1), Al(NaR)_(-1), and AlO(Fe(OH))_(-1) exchange vectors. A wider range of δ^(11)B values from -11.1‰ to -7.1‰ is observed in the wall-rock tourmaline crystals, the B isotopic values combining with elemental diagrams indicate a source of metasediments without marine evaporates for the wall rocks in the Qiman Tagh belt. The δ^(11)B values of monzogranite-hosted tourmaline range from -10.7‰ and-9.2‰, corresponding to the continental crust sediments, and indicate a possible connection between the wall rocks and the monzogranite. The overlap in δ^(11)B values between wall rocks and monzogranite implies that a transfer of δ^(11)B values by anataxis with little isotopic fractionation between tourmaline and melts. Tourmaline crystals from quartz veins have δ^(11)B values between -11.0‰ and-9.6‰, combining with the elemental diagrams and geological features, thus indicating a common granite-derived source for the quartz veins and little B isotopic fractionation occurred. Tourmalinite in the wall rocks was formed by metasomatism by a granite-derived hydrothermal fluid, as confirmed by the compositional and geological features.Therefore, we propose a single B-rich sedimentary source in the Qiman Tagh belt, and little boron isotopic fractionation occurred during systematic fluid evolution from the wall rocks, through monzogranite, to quartz veins and tourmalinite.展开更多
Ion cyclotron resonance heating(ICRH),which can produce fast ions,is an important auxiliary heating method at EAST.To analyze the effect of ICRH-induced fast ions on the plasma pressure at EAST,simulations are perform...Ion cyclotron resonance heating(ICRH),which can produce fast ions,is an important auxiliary heating method at EAST.To analyze the effect of ICRH-induced fast ions on the plasma pressure at EAST,simulations are performed using TRANSP and TORIC codes.It is found that the ICRF-induced fast ion pressure cannot be negligible when the ICRF power is sufficiently high.The magnitude of the total ion pressure can be raised up to 60%of the total pressure as the input power rises above 3 MW.The pressure profile is also significantly modified when the resonant layer is changed.It is shown that by changing the wave frequency and antenna position,the total ion pressure profile can be broadened,which might provide an option for profile control at EAST.展开更多
The equilibrium reconstruction is important to study the tokamak plasma physical processes.To analyze the contribution of fast ions to the equilibrium,the kinetic equilibria at two time-slices in a typical H-mode disc...The equilibrium reconstruction is important to study the tokamak plasma physical processes.To analyze the contribution of fast ions to the equilibrium,the kinetic equilibria at two time-slices in a typical H-mode discharge with different auxiliary heatings are reconstructed by using magnetic diagnostics,kinetic diagnostics and TRANSP code.It is found that the fast-ion pressure might be up to one-third of the plasma pressure and the contribution is mainly in the core plasma due to the neutral beam injection power is primarily deposited in the core region.The fast-ion current contributes mainly in the core region while contributes little to the pedestal current.A steep pressure gradient in the pedestal is observed which gives rise to a strong edge current.It is proved that the fast ion effects cannot be ignored and should be considered in the future study of EAST.展开更多
In this paper,a novel capacitor-inductor integrated structure was proposed.The dielectric material BaTiO3(BTO)and ferromagnetic material Ni0.5Zn0.5Fe2O4(NZFO)was prepared by sol-gel method.Phase composition and morpho...In this paper,a novel capacitor-inductor integrated structure was proposed.The dielectric material BaTiO3(BTO)and ferromagnetic material Ni0.5Zn0.5Fe2O4(NZFO)was prepared by sol-gel method.Phase composition and morphology of the thin films were characterized by XRD,SEM and AFM.The effect of annealing temperature on film crystallinity,surface morphology,dielectric properties and ferromagnetism was investigated.When the annealing temperature was 700°C,the BTO film and the NZFO film got the better dielectric properties and ferromagnetic properties.Then the BTO thin film was spin-coated on the substrate,and the NZFO thin film was in-situ sintered on the BTO thin film.The composite film possessed both ferromagnetism and dielectric properties.Finally,an inductive coil was fabricated on the BTO/NZFO composite film to produce a capacitance and inductance integrated device.展开更多
Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour metastasis.SIRT6 can promote the migration of pancreatic cancer and could be ...Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour metastasis.SIRT6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic cancer.However,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be discovered.Here,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/L.Moreover,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/L.The allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural analyses.Importantly,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver metastasis.To our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic cancer.It not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer.展开更多
The phenomenon of a target echo peak overlapping with the backscattered echo peak significantly undermines the detection range and precision of underwater laser fuzes.To overcome this issue,we propose a four-quadrant ...The phenomenon of a target echo peak overlapping with the backscattered echo peak significantly undermines the detection range and precision of underwater laser fuzes.To overcome this issue,we propose a four-quadrant dual-beam circumferential scanning laser fuze to distinguish various interference signals and provide more real-time data for the backscatter filtering algorithm.This enhances the algorithm loading capability of the fuze.In order to address the problem of insufficient filtering capacity in existing linear backscatter filtering algorithms,we develop a nonlinear backscattering adaptive filter based on the spline adaptive filter least mean square(SAF-LMS)algorithm.We also designed an algorithm pause module to retain the original trend of the target echo peak,improving the time discrimination accuracy and anti-interference capability of the fuze.Finally,experiments are conducted with varying signal-to-noise ratios of the original underwater target echo signals.The experimental results show that the average signal-to-noise ratio before and after filtering can be improved by more than31 d B,with an increase of up to 76%in extreme detection distance.展开更多
The pandemic of coronavirus disease 2019(COVID-19),caused by a novel severe acute respiratory syndrome(SARS)coronavirus 2(SARS-CoV-2),has caused an enormous impact on the global healthcare.SARS-CoV-2 infec-tion primar...The pandemic of coronavirus disease 2019(COVID-19),caused by a novel severe acute respiratory syndrome(SARS)coronavirus 2(SARS-CoV-2),has caused an enormous impact on the global healthcare.SARS-CoV-2 infec-tion primarily targets the respiratory system.Although most individuals testing positive for SARS-CoV-2 present mild or no upper respiratory tract symptoms,patients with severe COVID-19 can rapidly progress to acute respira-tory distress syndrome(ARDS).ARDS-related pulmonary fibrosis is a recognized sequelae of COVID-19.Whether post-COVID-19 lung fibrosis is resolvable,persistent,or even becomes progressive as seen in human idiopathic pulmonary fibrosis(IPF)is currently not known and remains a matter of debate.With the emergence of effective vaccines and treatments against COVID-19,it is now important to build our understanding of the long-term se-quela of SARS-CoV-2 infection,to identify COVID-19 survivors who are at risk of developing chronic pulmonary fibrosis,and to develop effective anti-fibrotic therapies.The current review aims to summarize the pathogenesis of COVID-19 in the respiratory system and highlights ARDS-related lung fibrosis in severe COVID-19 and the potential mechanisms.It envisions the long-term fibrotic lung complication in COVID-19 survivors,in particular in the aged population.The early identification of patients at risk of developing chronic lung fibrosis and the development of anti-fibrotic therapies are discussed.展开更多
基金the National Natural Science Foundation of China(Grant No.51522503)the Program for New Century Excellent Talents in University(NCET-13-0175).
文摘Copper nanowires(Cu NWs)are considered an excellent alternative to indium tin oxide(ITO)in flexible transparency electrodes(FTEs).However,the mixed particles and surface oxidation of Cu NWs degrade the transmittance and conductivity of the electrodes.Therefore,highly purified Cu NWs without oxidation are vital for high-performance FTEs.Herein,a facile and effective purification process is introduced to purify Cu NWs in a water and n-hexane system,which takes advantage of the differences in hydrophilicity between Cu NWs and Cu NPs caused by their different adsorption affinities to octadecylamine(ODA).At the same sheet resistance,the transmittance of the purified Cu NW-based FTEs improved approximately 2%compared to that of non-purified Cu NW-based FTEs.Immersion of the electrode in glacial acetic acid removed the surface organics and oxides.After only 40 s of treatment,the sheet resistance dramatically decreased from 10^5 Ohm/sq to 31 Ohm/sq with a transmittance of 85%.In addition,the Cu NW-based FTE conductors showed excellent flexibility(remaining stable after 1000 bending cycles).The Cu NW-based FTEs were further applied to fabricate a flexible transparent heater.At a voltage of 10 V,the temperature of the heater reached 73℃,demonstrating the potential applications of this material in various fields.
基金financially supported by the National Basic Research Program of China (No. 2014CB440800)China Geological Survey Bureau (No. 1212011140056)
文摘The Qiman Tagh W-Sn belt lies in the westernmost section of the East Kunlun Orogen, NW China, and is associated with early Paleozoic monzogranites, tourmaline is present throughout this belt. In this paper we report chemical and boron isotopic compositions of tourmaline from wall rocks, monzogranites, and quartz veins within the belt, for studying the evolution of ore-forming fluids. Tourmaline crystals hosted in the monzogranite and wall rocks belong to the alkali group, while those hosted in quartz veins belong to both the alkali and X-site vacancy groups. Tourmaline in the walk rocks lies within the schorl-dravite series and becomes increasingly schorlitic in the monzogranite and quartz veins. Detrital tourmaline in the wall rocks is commonly both optically and chemically zoned,with cores being enriched in Mg compared with the rims. In the Al-Fe-Mg and Ca-Fe-Mg diagrams,tourmaline from the wall rocks plots in the fields of Al-saturated and Ca-poor metapelite, and extends into the field of Li-poor granites, while those from the monzogranite and quartz veins lie within the field of Li-poor granites. Compositional substitution is best represented by the MgFe_(-1), Al(NaR)_(-1), and AlO(Fe(OH))_(-1) exchange vectors. A wider range of δ^(11)B values from -11.1‰ to -7.1‰ is observed in the wall-rock tourmaline crystals, the B isotopic values combining with elemental diagrams indicate a source of metasediments without marine evaporates for the wall rocks in the Qiman Tagh belt. The δ^(11)B values of monzogranite-hosted tourmaline range from -10.7‰ and-9.2‰, corresponding to the continental crust sediments, and indicate a possible connection between the wall rocks and the monzogranite. The overlap in δ^(11)B values between wall rocks and monzogranite implies that a transfer of δ^(11)B values by anataxis with little isotopic fractionation between tourmaline and melts. Tourmaline crystals from quartz veins have δ^(11)B values between -11.0‰ and-9.6‰, combining with the elemental diagrams and geological features, thus indicating a common granite-derived source for the quartz veins and little B isotopic fractionation occurred. Tourmalinite in the wall rocks was formed by metasomatism by a granite-derived hydrothermal fluid, as confirmed by the compositional and geological features.Therefore, we propose a single B-rich sedimentary source in the Qiman Tagh belt, and little boron isotopic fractionation occurred during systematic fluid evolution from the wall rocks, through monzogranite, to quartz veins and tourmalinite.
基金The authors would like to thank Doctors Guosheng Xu,Damao Yao,and Yongliang Li for helpful discussionsThis work was supported by the National Key R&D Program of China(Nos.2017YFE0300400,2017YFE0300406)National Natural Science Foundation of China(Nos.11575239,11775265).
文摘Ion cyclotron resonance heating(ICRH),which can produce fast ions,is an important auxiliary heating method at EAST.To analyze the effect of ICRH-induced fast ions on the plasma pressure at EAST,simulations are performed using TRANSP and TORIC codes.It is found that the ICRF-induced fast ion pressure cannot be negligible when the ICRF power is sufficiently high.The magnitude of the total ion pressure can be raised up to 60%of the total pressure as the input power rises above 3 MW.The pressure profile is also significantly modified when the resonant layer is changed.It is shown that by changing the wave frequency and antenna position,the total ion pressure profile can be broadened,which might provide an option for profile control at EAST.
基金supported by National Key R&D Program of China under Grant No.2017YFE0300400National Natural Science Foundation of China under Grant Nos.11475220,11405218,11575248+1 种基金the National Magnetic Confinement Fusion Science Program of China under Contracts No.2014GB106001sponsored in part by Youth Innovation Promotion Association Chinese Academy of Sciences (Grant No.2016384)
文摘The equilibrium reconstruction is important to study the tokamak plasma physical processes.To analyze the contribution of fast ions to the equilibrium,the kinetic equilibria at two time-slices in a typical H-mode discharge with different auxiliary heatings are reconstructed by using magnetic diagnostics,kinetic diagnostics and TRANSP code.It is found that the fast-ion pressure might be up to one-third of the plasma pressure and the contribution is mainly in the core plasma due to the neutral beam injection power is primarily deposited in the core region.The fast-ion current contributes mainly in the core region while contributes little to the pedestal current.A steep pressure gradient in the pedestal is observed which gives rise to a strong edge current.It is proved that the fast ion effects cannot be ignored and should be considered in the future study of EAST.
文摘In this paper,a novel capacitor-inductor integrated structure was proposed.The dielectric material BaTiO3(BTO)and ferromagnetic material Ni0.5Zn0.5Fe2O4(NZFO)was prepared by sol-gel method.Phase composition and morphology of the thin films were characterized by XRD,SEM and AFM.The effect of annealing temperature on film crystallinity,surface morphology,dielectric properties and ferromagnetism was investigated.When the annealing temperature was 700°C,the BTO film and the NZFO film got the better dielectric properties and ferromagnetic properties.Then the BTO thin film was spin-coated on the substrate,and the NZFO thin film was in-situ sintered on the BTO thin film.The composite film possessed both ferromagnetism and dielectric properties.Finally,an inductive coil was fabricated on the BTO/NZFO composite film to produce a capacitance and inductance integrated device.
基金supported by the National Key R&D Program of China(grant no.2022YFF1203005)the National Natural Science Foundation of China(22237005,81903458,82273425)+1 种基金Innovative research team of high-level local universities in Shanghai(SHSMU-ZDCX20212700,China)China Postdoctoral Science Foundation(2019M660090)。
文摘Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour metastasis.SIRT6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic cancer.However,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be discovered.Here,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/L.Moreover,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/L.The allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural analyses.Importantly,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver metastasis.To our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic cancer.It not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer.
基金supported by the 2021 Open Project Fund of Science and Technology on Electromechanical Dynamic Control Laboratory,grant number 212-C-J-F-QT-2022-0020China Postdoctoral Science Foundation,grant number 2021M701713+1 种基金Postgraduate Research&Practice Innovation Program of Jiangsu Province,grant number KYCX23_0511the Jiangsu Funding Program for Excellent Postdoctoral Talent,grant number 20220ZB245。
文摘The phenomenon of a target echo peak overlapping with the backscattered echo peak significantly undermines the detection range and precision of underwater laser fuzes.To overcome this issue,we propose a four-quadrant dual-beam circumferential scanning laser fuze to distinguish various interference signals and provide more real-time data for the backscatter filtering algorithm.This enhances the algorithm loading capability of the fuze.In order to address the problem of insufficient filtering capacity in existing linear backscatter filtering algorithms,we develop a nonlinear backscattering adaptive filter based on the spline adaptive filter least mean square(SAF-LMS)algorithm.We also designed an algorithm pause module to retain the original trend of the target echo peak,improving the time discrimination accuracy and anti-interference capability of the fuze.Finally,experiments are conducted with varying signal-to-noise ratios of the original underwater target echo signals.The experimental results show that the average signal-to-noise ratio before and after filtering can be improved by more than31 d B,with an increase of up to 76%in extreme detection distance.
基金This work was supported in part by NIH grants HL139584,HL156973,and EY027924.
文摘The pandemic of coronavirus disease 2019(COVID-19),caused by a novel severe acute respiratory syndrome(SARS)coronavirus 2(SARS-CoV-2),has caused an enormous impact on the global healthcare.SARS-CoV-2 infec-tion primarily targets the respiratory system.Although most individuals testing positive for SARS-CoV-2 present mild or no upper respiratory tract symptoms,patients with severe COVID-19 can rapidly progress to acute respira-tory distress syndrome(ARDS).ARDS-related pulmonary fibrosis is a recognized sequelae of COVID-19.Whether post-COVID-19 lung fibrosis is resolvable,persistent,or even becomes progressive as seen in human idiopathic pulmonary fibrosis(IPF)is currently not known and remains a matter of debate.With the emergence of effective vaccines and treatments against COVID-19,it is now important to build our understanding of the long-term se-quela of SARS-CoV-2 infection,to identify COVID-19 survivors who are at risk of developing chronic pulmonary fibrosis,and to develop effective anti-fibrotic therapies.The current review aims to summarize the pathogenesis of COVID-19 in the respiratory system and highlights ARDS-related lung fibrosis in severe COVID-19 and the potential mechanisms.It envisions the long-term fibrotic lung complication in COVID-19 survivors,in particular in the aged population.The early identification of patients at risk of developing chronic lung fibrosis and the development of anti-fibrotic therapies are discussed.
