Ten 3,5-dimethylcoumarins(1-6 and 8‒11)involving six new ones(1-6),together with a known 3-methylcoumarin(7),were isolated from the aerial parts of three Chelonopsis plants,C.praecox,C.odontochila,and C.pseudobracteat...Ten 3,5-dimethylcoumarins(1-6 and 8‒11)involving six new ones(1-6),together with a known 3-methylcoumarin(7),were isolated from the aerial parts of three Chelonopsis plants,C.praecox,C.odontochila,and C.pseudobracteata.The struc-tures of the new compounds were determined by extensive HRESIMS,1D and 2D NMR spectroscopic analyses.According to the substitution at C-5,these coumarins were classified into 5-methyl,5-hydroxymethyl,5-formyl,and 5-nor types.All the isolates were assayed for their inhibition onα-glucosidase,protein tyrosine phosphatase 1B,and T-cell protein tyrosine phosphatase in vitro.展开更多
基金the Yunnan Wanren Project(YNWR-QNBJ-2018-061)the Natural Science Foundation of Yunnan Province(2019FI017)the Reserve Talents of Young and Middle-Aged Academic and Technical Leaders in Yunnan Province.
文摘Ten 3,5-dimethylcoumarins(1-6 and 8‒11)involving six new ones(1-6),together with a known 3-methylcoumarin(7),were isolated from the aerial parts of three Chelonopsis plants,C.praecox,C.odontochila,and C.pseudobracteata.The struc-tures of the new compounds were determined by extensive HRESIMS,1D and 2D NMR spectroscopic analyses.According to the substitution at C-5,these coumarins were classified into 5-methyl,5-hydroxymethyl,5-formyl,and 5-nor types.All the isolates were assayed for their inhibition onα-glucosidase,protein tyrosine phosphatase 1B,and T-cell protein tyrosine phosphatase in vitro.
