A facile and efficient strategy has been developed to fabricate a multifunctional,theranostic anticancer drug delivery platform featuring active targeting,controlled drug release and fluorescence imaging for real-time...A facile and efficient strategy has been developed to fabricate a multifunctional,theranostic anticancer drug delivery platform featuring active targeting,controlled drug release and fluorescence imaging for real-time control of delivery.To this end,thermo sensitive poly(N-isopropyl acrylamide)(PNIPAM)nanospheres are decorated with peptide-Au cluster conjugates as a smart nanomedicine platform.A sophisticated trifunctional peptide is designed to release the anticancer drug doxorubicin(DOX),target cells and reduce Au^3+ions to form luminescent Au cluste rs.Importantly,the peptide-Au cluster moieties are attached to the PNIPAM nanospheres via amide bonds rather than noncovalent interactions,significantly improving their stability in biological medium and drug release efficiency.The in vitro experiments showed that DOX was released in an efficient and controlled manner under physiological conditions.展开更多
A periodical composite material pipe is proposed based on the Bragg scattering mechanism of phononic crystals (PCs). The band gap (BG) properties of the flexural wave in this PC pipe under axial load and hydro-pressur...A periodical composite material pipe is proposed based on the Bragg scattering mechanism of phononic crystals (PCs). The band gap (BG) properties of the flexural wave in this PC pipe under axial load and hydro-pressure are calculated using the transfer matrix (TM) method. The frequency response functions (FRFs) of the PC pipe under axial load and hydro-pressure are calculated using the finite element approach, and the mechanism is elucidated to illustrate the phenomenon. The results show that axial load and hydro-pressure and their combination all have a great influence on the flexural vibration proper ties. This research offers theoretical support for research on PC pipes with complex conditions and is of great significance in solving the problem of high pressure.展开更多
基金financial support from the National Natural Science Foundation of China(NSFC,Nos.51573013,51873016)support from the Shaanxi Natural Science Foundation(No.2018JM2004)+1 种基金NSFC(No.21705129)funded by the Helmholtz association,program Science and Technology of Nanosystems(STN)。
文摘A facile and efficient strategy has been developed to fabricate a multifunctional,theranostic anticancer drug delivery platform featuring active targeting,controlled drug release and fluorescence imaging for real-time control of delivery.To this end,thermo sensitive poly(N-isopropyl acrylamide)(PNIPAM)nanospheres are decorated with peptide-Au cluster conjugates as a smart nanomedicine platform.A sophisticated trifunctional peptide is designed to release the anticancer drug doxorubicin(DOX),target cells and reduce Au^3+ions to form luminescent Au cluste rs.Importantly,the peptide-Au cluster moieties are attached to the PNIPAM nanospheres via amide bonds rather than noncovalent interactions,significantly improving their stability in biological medium and drug release efficiency.The in vitro experiments showed that DOX was released in an efficient and controlled manner under physiological conditions.
基金the National Natural Science Foundation of China (Grant Nos. 51275519 and 11372346).
文摘A periodical composite material pipe is proposed based on the Bragg scattering mechanism of phononic crystals (PCs). The band gap (BG) properties of the flexural wave in this PC pipe under axial load and hydro-pressure are calculated using the transfer matrix (TM) method. The frequency response functions (FRFs) of the PC pipe under axial load and hydro-pressure are calculated using the finite element approach, and the mechanism is elucidated to illustrate the phenomenon. The results show that axial load and hydro-pressure and their combination all have a great influence on the flexural vibration proper ties. This research offers theoretical support for research on PC pipes with complex conditions and is of great significance in solving the problem of high pressure.
