Treatment of 3-acetylpseudaconie 6 and 3. 13-diacetylyunnaconitine 9 withNBS/acetone-H2O(2:1) at room temperature produced corresponding imine derivatives & and 10.respectively. in good yields. This is a novel si...Treatment of 3-acetylpseudaconie 6 and 3. 13-diacetylyunnaconitine 9 withNBS/acetone-H2O(2:1) at room temperature produced corresponding imine derivatives & and 10.respectively. in good yields. This is a novel simple and convenient method for preparation of theimine compounds.展开更多
Oxidation of 1 with KMnO_4 in acetone-H_2O (1:1) for 1h gave nevadenine 2 (38%). But. 3 was formed in 98% yield when prolonging time and raising temperature (40℃). Reaction of 1 and 10 with Conforth reagent afforded ...Oxidation of 1 with KMnO_4 in acetone-H_2O (1:1) for 1h gave nevadenine 2 (38%). But. 3 was formed in 98% yield when prolonging time and raising temperature (40℃). Reaction of 1 and 10 with Conforth reagent afforded the ketones 11 (55%), 12 (30%), and 13 (13%), 14 (20%). respectively. While oxidation of 7 and 15 with a variety of the oxidizing agents gave 17 only in low 20% of yield besides the minor 16. In addition. 1 was converted to 2 by the fungi Curvularia lunata.展开更多
文摘Treatment of 3-acetylpseudaconie 6 and 3. 13-diacetylyunnaconitine 9 withNBS/acetone-H2O(2:1) at room temperature produced corresponding imine derivatives & and 10.respectively. in good yields. This is a novel simple and convenient method for preparation of theimine compounds.
基金We thank the National Natural Science Foundation of China !(No. 393707) the Chengdu Diao Pharmaceutical Company for support
文摘Oxidation of 1 with KMnO_4 in acetone-H_2O (1:1) for 1h gave nevadenine 2 (38%). But. 3 was formed in 98% yield when prolonging time and raising temperature (40℃). Reaction of 1 and 10 with Conforth reagent afforded the ketones 11 (55%), 12 (30%), and 13 (13%), 14 (20%). respectively. While oxidation of 7 and 15 with a variety of the oxidizing agents gave 17 only in low 20% of yield besides the minor 16. In addition. 1 was converted to 2 by the fungi Curvularia lunata.
