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乳腺癌患者的D型人格特征与生存质量及预后的相关性分析 被引量:4
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作者 张宁 刘媛媛 +6 位作者 郑桂兰 苏楠 赵月 冀东 宋翠萍 窦雅琳 娄秀娟 《现代肿瘤医学》 CAS 2019年第15期2694-2698,共5页
目的:探讨分析乳腺癌患者的D型人格特征与生存质量及预后的相关性。方法:选取本院收治的112例乳腺癌患者作为研究对象,对所选患者均进行问卷调查,采用14项D型人格量表(DS14)进行D型人格特征的测量,将合并有D型人格特征的患者纳入合并组... 目的:探讨分析乳腺癌患者的D型人格特征与生存质量及预后的相关性。方法:选取本院收治的112例乳腺癌患者作为研究对象,对所选患者均进行问卷调查,采用14项D型人格量表(DS14)进行D型人格特征的测量,将合并有D型人格特征的患者纳入合并组,未合并D型人格特征的患者纳入未合并组。采用癌症患者生活质量评价量表(QLQ-C30)进行患者生存质量状况评估,研究分析所选患者D型人格特征与生存质量及预后的相关性。结果:所选112例乳腺癌患者中,D型人格特征的发生率为19.64%。在生活水平、医疗保险、合并基础疾病方面,合并组与未合并组对比存在明显差异(P<0.05)。术前,两组患者的功能指标与症状指标对比均无明显差异(P>0.05);术后6个月,合并组患者的功能指标均明显低于未合并组患者,症状指标均明显高于未合并组患者,两组对比存在明显差异(P<0.05)。合并组患者的躯体功能、角色功能、认知功能、情绪功能及总健康状况与NA存在明显负相关性(P<0.05),疲倦、失眠、食欲丧失、经济困难与NA存在明显正相关性(P<0.05);合并组患者的角色功能、认知功能、情绪功能、社会功能及总健康状况与SI存在明显负相关性(P<0.05),疲倦、疼痛、失眠、食欲丧失、经济困难与SI存在明显正相关性(P<0.05)。两组患者术后1年及2年的生存率对比无差异(P>0.05),但合并组患者术后5年的生存率明显低于未合并组患者,对比存在明显差异(P<0.05)。结论:D型人格特征与乳腺癌患者生存质量存在明显相关性,可作为预测乳腺癌患者生存质量恶化及不良预后的重要因素。 展开更多
关键词 乳腺癌 D型人格特征 生存质量 相关性
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三阴性乳腺癌BRCA1的表达与临床病理特征及预后的相关性 被引量:10
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作者 张宁 郑桂兰 +6 位作者 冀东 宋翠萍 窦雅琳 刘媛媛 苏楠 赵月 李建梅 《实用癌症杂志》 2019年第4期534-536,共3页
目的探讨三阴性乳腺癌(TNBC) BRCA1的表达与临床病理特征及预后的关系。方法收集190例TNBC患者为研究对象,同时选择190例非三阴性乳腺癌患者纳入对照组。患者均接受手术治疗,采用免疫组化方法检测肿瘤组织p53及BRCA1的表达情况;同时对T... 目的探讨三阴性乳腺癌(TNBC) BRCA1的表达与临床病理特征及预后的关系。方法收集190例TNBC患者为研究对象,同时选择190例非三阴性乳腺癌患者纳入对照组。患者均接受手术治疗,采用免疫组化方法检测肿瘤组织p53及BRCA1的表达情况;同时对TNBC进行随访,观察记录其生存率。结果 TNBC组p53阳性表达率明显高于对照组,BRCA1阳性表达率则低于对照组,差异有统计学意义(P <0. 05)。年龄<35岁、无淋巴结转移、TNM T1+T2及p53阳性与TNBC患者BRCA1阳性表达有关(P <0. 05); BRCA1指标阳性者较阴性者有较高的5年生存率,差异均有统计学意义(P <0. 05)。结论 BRCA1的表达与三阴性乳腺癌患者年龄、淋巴结转移,TNM临床分期及p53有关,并且可以影响患者的预后。 展开更多
关键词 三阴性乳腺癌 乳腺癌易感基因1 病理特征 预后
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Stochastic back analysis of permeability coefficient using generalized Bayesian method
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作者 zheng guilan Wang Yuan +1 位作者 Wang Fei Yang Jian 《Water Science and Engineering》 EI CAS 2008年第3期83-92,共10页
Owing to the fact that the conventional deterministic back analysis of the permeability coefficient cannot reflect the uncertainties of parameters, including the hydraulic head at the boundary, the permeability coeffi... Owing to the fact that the conventional deterministic back analysis of the permeability coefficient cannot reflect the uncertainties of parameters, including the hydraulic head at the boundary, the permeability coefficient and measured hydraulic head, a stochastic back analysis taking consideration of uncertainties of parameters was performed using the generalized Bayesian method. Based on the stochastic finite element method (SFEM) for a seepage field, the variable metric algorithm and the generalized Bayesian method, formulas for stochastic back analysis of the permeability coefficient were derived. A case study of seepage analysis of a sluice foundation was performed to illustrate the proposed method. The results indicate that, with the generalized Bayesian method that considers the uncertainties of measured hydraulic head, the permeability coefficient and the hydraulic head at the boundary, both the mean and standard deviation of the permeability coefficient can be obtained and the standard deviation is less than that obtained by the conventional Bayesian method. Therefore, the present method is valid and applicable. 展开更多
关键词 permeability coefficient stochastic back analysis generalized Bayesian method variable metric algorithm
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Erosion of the prismatic layer by the organic matrix during the formation of the nacre-prism transition layer in the shell of Pinctada fucata (Bivalvia, Mollusca) 被引量:3
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作者 LIU XiaoJun LIU Chang +6 位作者 SUN Juan ZHOU YuJuan zheng guilan ZHANG GuiYou WANG HongZhong XIE LiPing ZHANG RongQing 《Chinese Science Bulletin》 SCIE EI CAS 2011年第9期869-876,共8页
Three variants of the sequence of formation of the nacre-prism transition layer were observed in Pinctada fucata (Bivalvia, Mollusca) shells. In each case, the layer was formed by the organic matrix secreted by the ma... Three variants of the sequence of formation of the nacre-prism transition layer were observed in Pinctada fucata (Bivalvia, Mollusca) shells. In each case, the layer was formed by the organic matrix secreted by the mantle, together with the interprismatic organic envelope. The continuity of the organic phase throughout the shell was maintained as the new nacreous layer was formed on the nacre-prism transition layer. Changes in the interprismatic organic envelopes on either side of the nacre-prism transition zone indicated that the organic matrix of the nacre-prism transition layer becomes embedded into the organic phase of the prismatic layer. It is concluded that penetration and erosion of the prisms by the organic matrix generates a strong bond between the prismatic and nacreous layers. 展开更多
关键词 有机基质 珍珠层 过渡层 双壳类 棱镜 软体动物 侵蚀 棱柱
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A possible mechanism for the formation of annual growth lines in bivalve shells 被引量:1
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作者 LIU XiaoJun YAN zhenguang +4 位作者 zheng guilan ZHANG GuiYou WANG HongZhong XIE LiPing ZHANG RongQing 《Science China(Life Sciences)》 SCIE CAS 2011年第2期175-180,共6页
We report a unique shell margin that differed from the usual shell structure of Pinctada fucata.We observed empty organic envelopes in the prismatic layer and the formation of the nacreous layer in the shell margin.Al... We report a unique shell margin that differed from the usual shell structure of Pinctada fucata.We observed empty organic envelopes in the prismatic layer and the formation of the nacreous layer in the shell margin.All the characteristics of the growing margin indicated that the shell was growing rapidly.To explain this anomaly,we propose the concept of "jumping development".During jumping development,the center of growth in the bivalve shell jumps forward over a short time interval when the position of the mantle changes.Jumping development explains the unusual structure of the anomalous shell and the development of annual growth lines in typical shells.Annual growth lines are the result of a discontinuity in the shell microstructure induced by jumping development. 展开更多
关键词 生长纹 双壳类 可能机制 贝壳 跨越式发展 核壳结构 合浦珠母贝 时间间隔
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