Magnesium cylindrical parts have relatively poor mechanical properties and distinct anisotropy of microstructure,which hinder their application as structural components.To improve the performance of WE71 cylindrical p...Magnesium cylindrical parts have relatively poor mechanical properties and distinct anisotropy of microstructure,which hinder their application as structural components.To improve the performance of WE71 cylindrical parts,multi-direction forging(MDF)was introduced before back extrusion,and the microstructure and mechanical properties were investigated.Results of microstructure show that the grain size in the outer of the cylindrical bottom is refined from 30.1 to 27.7μm,the micro structure is more uniform and the dislocation density is higher.The bimodal grain structure is formed in the outer of the cylindrical wall,which is ascribed to the formation of MgsRE phases along grain boundaries.These phases result in the Zener pinning effect on grain boundaries and the reduction of DRX volume fraction.The texture type of the cylindrical bottom is<0001>‖ED and the cylindrical wall is<1010>‖ED,and the maximum pole intensity is 1.986 and 1.664,respectively.Results of the tensile test at room temperature show that combined improved strength and ductility of the cylindrical part is attained after introducing the MDF process.The ultimate tensile strength(UTS),yield strength(YS)and elongation are279 MPa,185 MPa and 12%at the bottom and 299 MPa,212 MPa and 20%at the wall.展开更多
To the Editor:Mycobacterium marinum is a nontuberculous mycobacterium that can cause opportunistic infections in humans,ranging from a single cutaneous lesion to disseminated disease.[1]It was first isolated from a fi...To the Editor:Mycobacterium marinum is a nontuberculous mycobacterium that can cause opportunistic infections in humans,ranging from a single cutaneous lesion to disseminated disease.[1]It was first isolated from a fish in 1926 and identified as a cause of human infection in 1951.[1]The estimated annual incidence ranges from 0.04 to 0.27 per 100,000 persons in different countries.Outbreaks of M.marinum infections related to handling fish are not common,but have also been reported.展开更多
Phenuiviridae,a member of the Bunyavirales order,can lead to significant human morbidity and mortality.Various phenuiviruses target specific cellular proteins and have strategies to counteract the effects of type I in...Phenuiviridae,a member of the Bunyavirales order,can lead to significant human morbidity and mortality.Various phenuiviruses target specific cellular proteins and have strategies to counteract the effects of type I interferon(IFN).Previous studies have shown that phenuiviruses infection inhibits the synthesis of type I IFNs,and viral nonstructural proteins(NSs)had been further identified as an IFN antagonist.This study found that the NSs proteins of Dabie bandavirus(DBV),Sandfly fever Sicilian virus(SFSV),and Uukuniemi virus(UUKV)can inhibit Sendai virus-induced activation of IFN-βpromoter and phosphorylation of IFN regulatory factor 3(IRF3).Moreover,detailed analysis revealed that the phenuivirus NSs protein could directly interact with retinoic acid inducible gene-I(RIG-I)and degrade it via a proteasome-dependent pathway.In short,this study demonstrate a novel mechanism of phenuiviruses to resist host antiviral immunity,which may help understand these pathogens and suggest novel therapeutic approaches.展开更多
基金Projects(51871195,51501015)supported by the National Natural Science Foundation of ChinaProject(TC170A5SU-1)supported by Ministry of Industry and Information Technology of China。
基金Project supported by the General Program of National Natural Science Foundation of China(51871195,51501015)。
文摘Magnesium cylindrical parts have relatively poor mechanical properties and distinct anisotropy of microstructure,which hinder their application as structural components.To improve the performance of WE71 cylindrical parts,multi-direction forging(MDF)was introduced before back extrusion,and the microstructure and mechanical properties were investigated.Results of microstructure show that the grain size in the outer of the cylindrical bottom is refined from 30.1 to 27.7μm,the micro structure is more uniform and the dislocation density is higher.The bimodal grain structure is formed in the outer of the cylindrical wall,which is ascribed to the formation of MgsRE phases along grain boundaries.These phases result in the Zener pinning effect on grain boundaries and the reduction of DRX volume fraction.The texture type of the cylindrical bottom is<0001>‖ED and the cylindrical wall is<1010>‖ED,and the maximum pole intensity is 1.986 and 1.664,respectively.Results of the tensile test at room temperature show that combined improved strength and ductility of the cylindrical part is attained after introducing the MDF process.The ultimate tensile strength(UTS),yield strength(YS)and elongation are279 MPa,185 MPa and 12%at the bottom and 299 MPa,212 MPa and 20%at the wall.
基金Academic promotion program of Shandong First Medical University(Nos. 2019LJ002, 2019RC007, and 2020RC001)Innovation Project of Shandong Academy of Medical Sciences+2 种基金the Shandong Province Taishan Scholar Project(Nos. tsqn201812124 and tspd20150214)Youth Technology Innovation Support Project of Shandong Colleges and Universities(No. 2019KJL003)Natural Science Foundation of Shandong Province(No. ZR2018BC020)
文摘To the Editor:Mycobacterium marinum is a nontuberculous mycobacterium that can cause opportunistic infections in humans,ranging from a single cutaneous lesion to disseminated disease.[1]It was first isolated from a fish in 1926 and identified as a cause of human infection in 1951.[1]The estimated annual incidence ranges from 0.04 to 0.27 per 100,000 persons in different countries.Outbreaks of M.marinum infections related to handling fish are not common,but have also been reported.
基金We thank Liu Yang for assistance in the confocal microscopy studies.We also thank Lishu Zheng for providing Sendai virus.This work was supported by the National Science Foundation of China(grant numbers 31270201)the National Basic Research Program(973 Program)of China(grant numbers 2011CB504700).
文摘Phenuiviridae,a member of the Bunyavirales order,can lead to significant human morbidity and mortality.Various phenuiviruses target specific cellular proteins and have strategies to counteract the effects of type I interferon(IFN).Previous studies have shown that phenuiviruses infection inhibits the synthesis of type I IFNs,and viral nonstructural proteins(NSs)had been further identified as an IFN antagonist.This study found that the NSs proteins of Dabie bandavirus(DBV),Sandfly fever Sicilian virus(SFSV),and Uukuniemi virus(UUKV)can inhibit Sendai virus-induced activation of IFN-βpromoter and phosphorylation of IFN regulatory factor 3(IRF3).Moreover,detailed analysis revealed that the phenuivirus NSs protein could directly interact with retinoic acid inducible gene-I(RIG-I)and degrade it via a proteasome-dependent pathway.In short,this study demonstrate a novel mechanism of phenuiviruses to resist host antiviral immunity,which may help understand these pathogens and suggest novel therapeutic approaches.
