A model specimen with a single boundary of theα/βphase simulating Mg-Al alloys was successfully fabricated by spark plasma sintering.A small electrode area ofαphase orβphase was prepared using the model specimen,a...A model specimen with a single boundary of theα/βphase simulating Mg-Al alloys was successfully fabricated by spark plasma sintering.A small electrode area ofαphase orβphase was prepared using the model specimen,and the OCPs(open-circuit potentials)of each phase and a small electrode area containing theα/βphase boundary in 0.1 M NaCl at pH 8.0 were compared:theβphase exhibited a higher potential,and theαphase showed a lower potential.The OCP of the small area containing theα/βphase boundary was the intermediate value of these phases.In a small area containingα/βphase boundary,discoloration and gas bubbles were observed on theαphase,but no bubble generation was detected on theβphase.The gas bubbles were initially generated on theαphase near theβphase,but as the discoloration(corrosion)of theαphase approached theβphase,the bubbles were generated on theβphase.In micro-galvanic corrosion of theαandβphases,theβphase did not always function as the preferred cathode.Theαphase partially corroded(or discolored)and became the anodes,so that the surrounding areas were most likely to be the cathodes.When corroded areas(anodes)in theαphase approached theβphase,theβphase would become cathodes.In addition to the micro-galvanic corrosion mechanism,the role of Al in corrosion resistance at theα/βphase boundary was determined by surface analysis.展开更多
Objective:To identify novel drug targets for treatment of Plasmodium falciparum.Methods: Local BT.ASTP were used to find the proteins non-homologous to human essential proteins as novel drug targets.Functional domains...Objective:To identify novel drug targets for treatment of Plasmodium falciparum.Methods: Local BT.ASTP were used to find the proteins non-homologous to human essential proteins as novel drug targets.Functional domains of novel drug targets were identified by InterPro and Pfam.3D structures of potential drug targets were predicated by the SWISS-MODEL workspace. Ligands and ligand-binding sites of the proteins were searched by Ef-seek.Results:Three essential proteins were identified that might be considered as potential drug targets.AAN37254.1 belonged to 1-deoxy-D-xylulose 5-phosphate reductoisomerase,CAD50499.1 belonged to chorismale synthase,CAD51220.1 belonged to FAD binging 3 family,but the function of CAD51220.1 was unknown.The 3D structures,ligands and ligand-binding sites of AAM37254.1 and CAD50499.1 were successfully predicated.Conclusions:Two of these potential drug targets are key enzymes in 2-C-methyl-d-erythritol 4-phosphate pathway and shikimate pathway, which are absent in humans,so these two essential proteins are good potential drug targets.The function and 3D structures of CAD50499.1 is still unknown,it still need further study.展开更多
基金supported by JSPS KAKENHI Grant Numbers JP17H01331 and JP21K18804supported by The Light Metal Educational Foundation Inc.of Japansupported by Amano Institute of Technology and China Scholarship Council。
文摘A model specimen with a single boundary of theα/βphase simulating Mg-Al alloys was successfully fabricated by spark plasma sintering.A small electrode area ofαphase orβphase was prepared using the model specimen,and the OCPs(open-circuit potentials)of each phase and a small electrode area containing theα/βphase boundary in 0.1 M NaCl at pH 8.0 were compared:theβphase exhibited a higher potential,and theαphase showed a lower potential.The OCP of the small area containing theα/βphase boundary was the intermediate value of these phases.In a small area containingα/βphase boundary,discoloration and gas bubbles were observed on theαphase,but no bubble generation was detected on theβphase.The gas bubbles were initially generated on theαphase near theβphase,but as the discoloration(corrosion)of theαphase approached theβphase,the bubbles were generated on theβphase.In micro-galvanic corrosion of theαandβphases,theβphase did not always function as the preferred cathode.Theαphase partially corroded(or discolored)and became the anodes,so that the surrounding areas were most likely to be the cathodes.When corroded areas(anodes)in theαphase approached theβphase,theβphase would become cathodes.In addition to the micro-galvanic corrosion mechanism,the role of Al in corrosion resistance at theα/βphase boundary was determined by surface analysis.
基金supported by Science and Technology Innovation Fund of Guangdong Medical College(No.STIF 201107)
文摘Objective:To identify novel drug targets for treatment of Plasmodium falciparum.Methods: Local BT.ASTP were used to find the proteins non-homologous to human essential proteins as novel drug targets.Functional domains of novel drug targets were identified by InterPro and Pfam.3D structures of potential drug targets were predicated by the SWISS-MODEL workspace. Ligands and ligand-binding sites of the proteins were searched by Ef-seek.Results:Three essential proteins were identified that might be considered as potential drug targets.AAN37254.1 belonged to 1-deoxy-D-xylulose 5-phosphate reductoisomerase,CAD50499.1 belonged to chorismale synthase,CAD51220.1 belonged to FAD binging 3 family,but the function of CAD51220.1 was unknown.The 3D structures,ligands and ligand-binding sites of AAM37254.1 and CAD50499.1 were successfully predicated.Conclusions:Two of these potential drug targets are key enzymes in 2-C-methyl-d-erythritol 4-phosphate pathway and shikimate pathway, which are absent in humans,so these two essential proteins are good potential drug targets.The function and 3D structures of CAD50499.1 is still unknown,it still need further study.
