By using the iterative method in functional theory, an analytic expression of the Poisson-Boltzmann equation (PB eq.), which describes the distribution of the potential of electrical double layer of a spherical micell...By using the iterative method in functional theory, an analytic expression of the Poisson-Boltzmann equation (PB eq.), which describes the distribution of the potential of electrical double layer of a spherical micelle, has been carried out under the general potential condition for the first time. The method also can give the radius, the surface potential, and the thickness of the layer.展开更多
The synthesis and labeling of ^(99m)Tc-N^3-(N'-[2-sulfanyl-ethylamino)acetyl]-2-aminoethyl-sulfanyl-1-hexanamide}thymidine (^(99m)Tc-NHT) were studied.In the presence of sodium glucoheptonate(GH) and ethyle...The synthesis and labeling of ^(99m)Tc-N^3-(N'-[2-sulfanyl-ethylamino)acetyl]-2-aminoethyl-sulfanyl-1-hexanamide}thymidine (^(99m)Tc-NHT) were studied.In the presence of sodium glucoheptonate(GH) and ethylene diamine tetraacetic acid(EDTA),^(99m)Tc-NHT was obtained by using bisaminoethanethiol(N_2S_2) as a bifunctional coupling agent.The radiochemical purity of the ^(99m)Tc-NHT was over 95%.Biodistribution of ^(99m)Tc-NHT was performed in hepatoma HepA tumor-bearing mice.At 2 h p.i.,the ratios of tumor-to-muscle,tumor-to-bone and tumor-to-blood were 4.41±0.32,2.45±0.24 and 1.51±0.18,respectively.展开更多
基金We wish to thank to the National Natural Science Foundation of China(to grant No,29903006 and 29973023)the Visiting Scholar Foundation of Key Laboratory in University of China for financial suppor.
文摘By using the iterative method in functional theory, an analytic expression of the Poisson-Boltzmann equation (PB eq.), which describes the distribution of the potential of electrical double layer of a spherical micelle, has been carried out under the general potential condition for the first time. The method also can give the radius, the surface potential, and the thickness of the layer.
基金provided by Natural Science Foundation of Jiangsu Province(NoBK2008112)Department of Health of Jiangsu Province(NoH200624)
文摘The synthesis and labeling of ^(99m)Tc-N^3-(N'-[2-sulfanyl-ethylamino)acetyl]-2-aminoethyl-sulfanyl-1-hexanamide}thymidine (^(99m)Tc-NHT) were studied.In the presence of sodium glucoheptonate(GH) and ethylene diamine tetraacetic acid(EDTA),^(99m)Tc-NHT was obtained by using bisaminoethanethiol(N_2S_2) as a bifunctional coupling agent.The radiochemical purity of the ^(99m)Tc-NHT was over 95%.Biodistribution of ^(99m)Tc-NHT was performed in hepatoma HepA tumor-bearing mice.At 2 h p.i.,the ratios of tumor-to-muscle,tumor-to-bone and tumor-to-blood were 4.41±0.32,2.45±0.24 and 1.51±0.18,respectively.