Organ-associated pseudosarcomatous myofibroblastic proliferation with ossification in the lower pole of the kidney mimicking renal pelvic carcinoma: A case report

BACKGROUND Organ-associated pseudosarcomatous myofibroblastic proliferation (PMP) is a very rare disorder.In the urogenital tract,PMP preferentially involves the urinary bladder;kidney involvement is rare.Here,we report a rare case of PMP with ossification in the lower pole of the kidney,which mimics urothelial carcinoma or an osteogenic tumor.CASE SUMMARY A Chinese man was admitted to our hospital due to intermittent hematuria for more than 1 mo.Enhanced renal computed tomography revealed a mass in the left renal pelvis and upper ureter.The preoperative clinical diagnosis was renal pelvic carcinoma,determined by imaging examination and biopsy.After a standard preparation for surgery,the patient underwent retroperitoneoscopic radical nephroureterectomy.The operative findings were an extensive renal tumor (6 cm × 4.5 cm × 4.5 cm) invading the lower pole of the kidney and upper ureter.The final pathological diagnosis was organ-associated PMP with ossification.After 6-mo follow-up,no recurrence or metastasis was found.CONCLUSION This case of PMP was unusual for its mimicking renal pelvic carcinoma in imaging examinations,making biopsy necessary.

Tailoring mechanical heterogeneity,nanoscale creep deformation and optical properties of nanostructured Zr-based metallic glass

Metallic glasses are spatially heterogeneous at the nanometer scale.However,the effects of external excitation on their structural and mechanical heterogeneity and the correlation to their properties are still unresolved.Nanoindentation,atomic force microscopy(AFM) and high-resolution transmis sion elec tron micro scopy(HRTEM) were carried out to explore the effects of cryogenic thermal cycling(CTC) on mechanical/structural heterogeneity,nano sc ale creep deformation and optical properties of nano structured metallic glass thin films(MGTFs).The results indicate that CTC treatment alters the distribution fluctuations of hardness/modulus and energy dissipation and results in an increase-then-decrease variation in mechanical heterogeneity.By applying Maxwell-Voigt model,it can be shown that CTC treatment results in a remarkable activation of more defects with longer relaxation time in soft regions but has only a slight effect on defects in hard regions.In addition,CTC treatment increases the transition time from primary-state stage to steady-state stage during creep deformation.The enhanced optical reflectivity of the MGTFs after 15 thermal cycles can be attributed to increased aggregation of Cu and Ni elements.The results of this study shed new light on understanding mechanical/structural heterogeneity and its influence on nanoscale creep deformation and optical characteristics of nanostructured MGTFs,and facilitate the design of high-performance nanostructured MGTFs.