Reductive Coupling of Aryl Halides via C-H Activation of Indene

This paper describes the first case of a reductive coupling reaction with indene,a non-heteroatom olefin used as a reducing agent.The scope of the substrate is wide.The homo-coupling,cross-coupling,and synthesis of 12 and 14-membered rings were realized.The control experiment,indene-product curve and density functional theory calculations showed that the η^(3)-palladium indene intermediate was formed by C-H activation in the presence of cesium carbonate.We speculate that the final product was obtained through a Pd(IV)intermediate or aryl ligand exchange.In addition,we excluded the formation of palladium anion(Pd(0)^(-))intermediates.

PEG-SO_3H as an efficient and reusable catalyst for chemoselective synthesis of 1,1-diacetates

Received 20 November 2012 Received in revised form 13 December 2012 Accepted 21 December 2012 Available online 29 January 2013

Visible light promoted polyhalomethylation of alkenes: alkylation and cyclization

We report a visible light promoted carbochloromethylation of 2-bromomethyl acrylate and N-arylmethacrylamide,and a series of trihalomethyl substituted allylic acid esters and indolone derivatives were synthesized.The reaction used common and inexpensive chloroform and tribromomethane as tri-halomethyl reagents,iodobenzene diacetate(PIDA)as an oxidant and Eosin Y as a photocatalyst.The reaction conditions are mild and the substrate scope is wide.

Direct amination of pyrimidin-2-yl tosylates with aqueous ammonia under metal-free and mild conditions

A metal-flee synthesis of pyrimidine functionalized primary amines via direct amination of pyrimidin-2- yl tosylate with aqueous ammonia has been developed under mild conditions. The desired products pyrimidin-2-amines can be generated in excellent yields in PEG-400, without any catalysts or other additives.