Objective:To investigate the influencing factors of chronic hepatitis B with nonalcoholic fatty liver disease,and to provide a reference for screening and clinical treatment of high-risk groups.Methods:A case-control ...Objective:To investigate the influencing factors of chronic hepatitis B with nonalcoholic fatty liver disease,and to provide a reference for screening and clinical treatment of high-risk groups.Methods:A case-control study was conducted.According to the inclusion and exclusion criteria,133 cases of newly diagnosed patients with CHB combined with NAFLD were enrolled in the Affiliated Hospital of North China University of Technology and Tangshan Infectious Disease Hospital from January 2015 to January 2018.139 cases of newly diagnosed patients with CHB diagnosed in the same period were selected as the control group.The clinical data,initial laboratory examination and imaging findings of the two groups of patients were compared to analyze the influencing factors of chronic hepatitis B combined with nonalcoholic fatty liver disease.Results:1 The BMI,ALT,AST,GGT,FBG,TG and CAP in the case group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).The control group HDL-C,HBcAb,type III procollagen amino terminal peptide,The type IV collagen,laminin and LSM were higher than the case group,the difference was statistically significant(P<0.05).The case group was more likely to be associated with complications,and the difference was statistically significant(P=0.01).2 Univariate analysis showed that About the author:Zhang Guoshun,male,chief physician,professor,master's tutor,doctoral,mainly engaged in research and prevention of liver diseases,13930565676,zguoshun@sina.com.Fund Project:China Hepatitis Prevention Foundation Funded Project(No.:TQGB20170015);Hebei Province Medical Science Research Key Project(No.20170933);North China University of Technology Graduate Innovation Project(No.2019S49)patients in the case group had BMI≥25Kg/m2,GGT>45U/L,type IV collagen≤140ng/ml,laminin≤140ng/ml,CAP≥283dB/m,hyperglycemia,high glycerol The proportion of patients with lipemia was significantly higher than that of the control group,the difference was statistically significant(P<0.05);3 binary logistic regression analysis showed that GGT,FBG,BMI,laminin,CAP were predictive of chronic hepatitis B combined with non-An effective indicator of alcoholic fatty liver disease.Conclusion 1GGT,BMI,FBG,laminin and CAP are the influencing factors of CHB combined with NAFLD.The occurrence of 2NAFLD is closely related to obesity,hyperglycemia and hypertriglyceridemia.The HBcAb and liver fibrosis indexes are decreased when CHB combined with NAFLD,and the mechanism is still unclear.展开更多
文摘Objective:To investigate the influencing factors of chronic hepatitis B with nonalcoholic fatty liver disease,and to provide a reference for screening and clinical treatment of high-risk groups.Methods:A case-control study was conducted.According to the inclusion and exclusion criteria,133 cases of newly diagnosed patients with CHB combined with NAFLD were enrolled in the Affiliated Hospital of North China University of Technology and Tangshan Infectious Disease Hospital from January 2015 to January 2018.139 cases of newly diagnosed patients with CHB diagnosed in the same period were selected as the control group.The clinical data,initial laboratory examination and imaging findings of the two groups of patients were compared to analyze the influencing factors of chronic hepatitis B combined with nonalcoholic fatty liver disease.Results:1 The BMI,ALT,AST,GGT,FBG,TG and CAP in the case group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).The control group HDL-C,HBcAb,type III procollagen amino terminal peptide,The type IV collagen,laminin and LSM were higher than the case group,the difference was statistically significant(P<0.05).The case group was more likely to be associated with complications,and the difference was statistically significant(P=0.01).2 Univariate analysis showed that About the author:Zhang Guoshun,male,chief physician,professor,master's tutor,doctoral,mainly engaged in research and prevention of liver diseases,13930565676,zguoshun@sina.com.Fund Project:China Hepatitis Prevention Foundation Funded Project(No.:TQGB20170015);Hebei Province Medical Science Research Key Project(No.20170933);North China University of Technology Graduate Innovation Project(No.2019S49)patients in the case group had BMI≥25Kg/m2,GGT>45U/L,type IV collagen≤140ng/ml,laminin≤140ng/ml,CAP≥283dB/m,hyperglycemia,high glycerol The proportion of patients with lipemia was significantly higher than that of the control group,the difference was statistically significant(P<0.05);3 binary logistic regression analysis showed that GGT,FBG,BMI,laminin,CAP were predictive of chronic hepatitis B combined with non-An effective indicator of alcoholic fatty liver disease.Conclusion 1GGT,BMI,FBG,laminin and CAP are the influencing factors of CHB combined with NAFLD.The occurrence of 2NAFLD is closely related to obesity,hyperglycemia and hypertriglyceridemia.The HBcAb and liver fibrosis indexes are decreased when CHB combined with NAFLD,and the mechanism is still unclear.
