期刊文献+

二次检索

题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

年份

共找到3篇文章
< 1 >
每页显示 20 50 100
Identification and analysis of core target genes of miR-29b-3p in glioma
1
作者 Sheng-Hua Zhuo liang-Wang Yang +4 位作者 Shen-Bo Chen Jin-Ben Zhang Zhao-Teng Zhang zheng-zheng li Kun Yang 《Journal of Hainan Medical University》 2022年第4期17-21,共5页
Objective:To investigate the core target genes of miR-29b-3p,and analyze the clinical significance of the core target genes in glioma.Methods:Bioinformatics analysis was used to predict and screen the target genes of ... Objective:To investigate the core target genes of miR-29b-3p,and analyze the clinical significance of the core target genes in glioma.Methods:Bioinformatics analysis was used to predict and screen the target genes of miR-29b-3p.STRING and Cytoscape software were used to analyze the protein-protein interaction(PPI)of target genes.the differences expression and survival prognosis in glioma were analyzed by GEPIA and CGGA.Independent prognostic factors analyzed by univariate and multivariate Cox proportional hazards regression model.Results:22 target genes of miR-29b-3p were predicted using LinkedOmics,miRDB,miRTarBase,TargetScan,and starbase databases.Through the construction of the PPI network,genes out of the network were removed,and a total of 16 genes were screened for further study of their clinical significance.Based on analysis of GEPIA and CGGA databases,COL2A1,DNMT3A,and DNMT3B were excluded.Through further analysis of the univariate and multivariate Cox proportional hazard regression model,finally identified three core target genes:SERPINH1,LOXL2,CDK6.Conclusion:Bioinformatics analysis showed that miR-29b-3p targeted three core genes such as SERPINH1,LOXL2,and CDK6 in glioma.The expression of these genes was different between brain normal tissues and gliomas,between different grades of tumor,IDH mutation status and 1p/19q codeletion status.Its high expression had adverse effects on overall survival and recurrence-free survival.These core target genes can be used as an independent prognostic factor. 展开更多
关键词 GLIOMA miR-29b-3p Target gene PROGNOSIS BIOINFORMATICS
下载PDF
血尿酸、MMP-3水平与银杏达莫注射液治疗大动脉粥样硬化型缺血性脑卒中疗效的相关性 被引量:7
2
作者 张楠 郦铮铮 +2 位作者 潘思培 郑晓露 祁晓媛 《中国现代医学杂志》 CAS 北大核心 2021年第9期7-12,共6页
目的分析血尿酸、基质金属蛋白酶-3(MMP-3)水平与银杏达莫注射液辅助治疗大动脉粥样硬化型缺血型脑卒中疗效的相关性,并评估血清各项指标预测疗效的价值。方法回顾性分析2018年2月—2019年11月于沧州市中心医院接受银杏达莫注射液辅助... 目的分析血尿酸、基质金属蛋白酶-3(MMP-3)水平与银杏达莫注射液辅助治疗大动脉粥样硬化型缺血型脑卒中疗效的相关性,并评估血清各项指标预测疗效的价值。方法回顾性分析2018年2月—2019年11月于沧州市中心医院接受银杏达莫注射液辅助治疗的82例大动脉粥样硬化型缺血性脑卒中患者的临床资料,根据疗效分为A组(基本治愈)、B组(显效)、C组(有效)和D组(无效)。检测并比较各组血尿酸、MMP-3、同型半胱氨酸(Hcy)、白细胞介素-10(IL-10)水平,分析血清各项指标与疗效的相关性,绘制受试者工作特征(ROC)曲线,检验各指标用于预测疗效的价值。结果血尿酸、MMP-3、Hcy水平D组>C组>B组>A组(P<0.05);IL-10水平D组<C组<B组<A组(P<0.05)。血尿酸、MMP-3及Hcy与疗效呈负相关(r=-0.524、-0.486和-0.245,均P<0.05);IL-10与疗效呈正相关(r=0.781,P<0.05)。ROC曲线结果显示,血尿酸、MMP-3、Hcy、IL-10预测银杏达莫注射液辅助治疗大动脉粥样硬化型缺血性脑卒中疗效的敏感性分别为0.902、0.845、0.713、0.685,特异性分别为0.785、0.781、0.684、0.684。结论血尿酸、MMP-3水平可作为预测银杏达莫注射液辅助治疗大动脉粥样硬化型缺血性脑卒中疗效的血清学指标,且两者水平与疗效呈负相关,故临床治疗时需积极调节患者血尿酸、MMP-3水平。 展开更多
关键词 大动脉粥样硬化型缺血性脑卒中 银杏达莫注射液 血尿酸 基质金属蛋白酶-3 疗效 相关性
下载PDF
Restoration of pseudo-spin symmetry in N = 32 and N = 34 isotones described by relativistic Hartree-Fock theory
3
作者 zheng-zheng li Shi-Yao Chang +2 位作者 Qiang Zhao Wen-Hui Long Yi-Fei Niu 《Chinese Physics C》 SCIE CAS CSCD 2019年第7期79-85,共7页
The restoration of pseudo-spin symmetry(PSS) along the N = 32 and N = 34 isotonic chains and the physics behind are studied by applying the relativistic Hartree-Fock theory with the effective Lagrangian PKA1. Taking... The restoration of pseudo-spin symmetry(PSS) along the N = 32 and N = 34 isotonic chains and the physics behind are studied by applying the relativistic Hartree-Fock theory with the effective Lagrangian PKA1. Taking the proton pseudo-spin partners(π2s1/2, π1d3/2) as candidates, the systematic restoration of PSS along both isotonic chains is found from sulphur(S) to nickel(Ni), while an obvious PSS violation from silicon(Si) to sulphur is discovered near the drip lines. The effects of the tensor force components are investigated, introduced naturally by the Fock terms, which can only partially interpret the systematics from calcium to nickel, whereas they fail for the overall trends. Further analysis following the Schr?dinger-like equation of the lower component of Dirac spinor shows that contributions from the Hartree terms dominate the overall systematics of the PSS restoration. Such effects can be self-consistently interpreted by the evolution of the proton central density profiles along both isotonic chains. In particular, the PSS violation is found to tightly relate to the dramatic changes from the bubble-like density profiles in silicon to the central-bumped ones in sulphur. 展开更多
关键词 pseudo-spin SYMMETRY RELATIVISTIC HARTREE-FOCK theory TENSOR force bubble-like structure
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部