Summary of main observation and con elusion In this work,a new simple and readily synthesized turn-on probe 2-(4-anthracene-9-yl-phenyl)-2H-[l,2,3]triazole-4-carbaldehyde(APTC)was legitimately designed towards homocys...Summary of main observation and con elusion In this work,a new simple and readily synthesized turn-on probe 2-(4-anthracene-9-yl-phenyl)-2H-[l,2,3]triazole-4-carbaldehyde(APTC)was legitimately designed towards homocysteine(Hcy).Moreover,APTC has excellent optical properties such as intramolecular charge transfer(ICT)and aggregation induced emission enhancement(AIEE)characteristics,indicating its extensive application potentiality.What's more,APTC displayed rapid,high selectivity and specificity towards homocysteine over cysteine/glutathione.The detection limit of APTC for Hcy was as low as 2.198×10^-8 mol·L^-1,and the response time was only 5 min.APTC has been successfully applied to detect Hcy in silica gel plates and living cells,which indicates that APTC has good stability and biocompatibility as a selective probe for Hcy.Finally,the mechanism was studied using 1H NMR titration experiments and mass spectrometry.展开更多
基金The authors are extremely grateful to the National Nature Science Foundation of China for supporting this research （No.20962018, No20862015, No.20762009 and No.20562011）.
基金The author is grateful to SWPU's Youth Science and Technology Innovation Team(No.2017CXTD05)。
文摘Summary of main observation and con elusion In this work,a new simple and readily synthesized turn-on probe 2-(4-anthracene-9-yl-phenyl)-2H-[l,2,3]triazole-4-carbaldehyde(APTC)was legitimately designed towards homocysteine(Hcy).Moreover,APTC has excellent optical properties such as intramolecular charge transfer(ICT)and aggregation induced emission enhancement(AIEE)characteristics,indicating its extensive application potentiality.What's more,APTC displayed rapid,high selectivity and specificity towards homocysteine over cysteine/glutathione.The detection limit of APTC for Hcy was as low as 2.198×10^-8 mol·L^-1,and the response time was only 5 min.APTC has been successfully applied to detect Hcy in silica gel plates and living cells,which indicates that APTC has good stability and biocompatibility as a selective probe for Hcy.Finally,the mechanism was studied using 1H NMR titration experiments and mass spectrometry.
