Frequency Domain Goodness of Fit Test Based Spectrum Sensing Method with Dynamically Varying Noise

In cognitive radio networks,spectrum sensing under circumstances of dynamically varying noise and lacking prior information is a key challenge to the conventional spectrum sensing algorithms.Since the necessary information is rather difficult to obtain practically,most existing spectrum sensing methods are fettered in applications.Motivated by these,in this paper,a Frequency domain Goodness of Fit Test(FGoF)based spectrum sensing method is proposed.The FGoF makes full use of underlying information in Guard-Bands and the advantages of GoF test works for any distribution.Analytical and simulated results show that the FGoF is a robust spectrum sensing method in cognitive radio with the inherent advantages of invulnerability to dynamically varying noise.

Tildrakizumab for moderate-to-severe plaque psoriasis in Chinese patients:A 12-week randomized placebo-controlled phase III trial with long-term extension

Background:There is a need for effective and safe therapies for psoriasis that provide sustained benefits.The aim of this study was to assess the efficacy and safety of tildrakizumab,an anti-interleukin-23p19 monoclonal antibody,for treating moderate-to-severe plaque psoriasis in Chinese patients.Methods:In this multi-center,double-blind,phase III trial,patients with moderate-to-severe plaque psoriasis were enrolled and randomly assigned(1:1)to receive subcutaneous tildrakizumab 100 mg or placebo at weeks 0 and 4.Patients initially assigned to placebo were switched to receive tildrakizumab at weeks 12,16,and every 12 weeks thereafter.Patients in the tildrakizumab group continued with tildrakizumab at week 16,and every 12 weeks until week 52.The primary endpoint was the Psoriasis Area and Severity Index(PASI 75)response rate at week 12.Results:At week 12,tildrakizumab demonstrated significantly higher PASI 75 response rates(66.4%[73/110]vs.12.7%[14/110];difference,51.4%[95%confidence interval(CI),40.72,62.13];P<0.001)and Physician’s Global Assessment(60.9%[67/110]vs.10.0%[11/110];difference,49.1%[95%CI,38.64,59.62];P<0.001)compared to placebo.PASI 75 response continued to improve over time in both tildrakizumab and placebo-switching to tildrakizumab groups,reaching maximal efficacy after 28 weeks(86.8%[92/106]vs.82.4%[89/108])and maintained up to 52 weeks(91.3%[95/104]vs.87.4%[90/103]).Most treatment-emergent adverse events were mild and not related to tildrakizumab.Conclusion:Tildrakizumab demonstrated durable efficacy through week 52 and was well tolerated in Chinese patients with moderate-to-severe plaque psoriasis.Trial registration:ClinicalTrials.gov,NCT05108766.

Prevalence of psoriatic arthritis in Chinese population with psoriasis:A multicenter study conducted by experienced rheumatologists

Background:Reports on the prevalence of psoriatic arthritis(PsA)among Chinese patients with psoriasis are very limited.This study,conducted by rheumatologists,estimated the prevalence of PsA in a large number of Chinese patients with psoriasis.Methods:Consecutive patients with a confirmed diagnosis of psoriasis attending nine dermatology clinics in five hospitals were recruited.All psoriasis patients were asked to complete a questionnaire comprising 16 questions to identify possible cases of PsA.All patients with one or more positive answers to the questionnaire were evaluated by two experienced rheumatologists.Results:A total of 2434 psoriasis patients,including 1561 males and 873 females,were enrolled.Both the questionnaire and rheumatologists’examinations were completed in the dermatology clinics.The results identified 252 patients with PsA,comprising 168 males and 84 females.The overall prevalence of PsA among psoriasis patients was 10.4%(95%confidence interval[95%CI],9.1%-11.7%).By sex,the prevalence was 10.8%(95%CI,9.2%-12.5%)for males and 9.6%(95%CI,7.7%-11.9%)for females and there was no significant sex difference in the prevalence of PsA(P=0.38).Of the 252 PsA patients,125(49.6%,95%CI,41.3%-59.1%)were newly diagnosed by rheumatologists.Consequently,the prevalence of undiagnosed PsA among psoriasis patients was 5.2%(95%CI,4.4%-6.2%).Conclusion:The prevalence of PsA in the Chinese population with psoriasis is about 10.4%,which is almost double that of previous reports in the Chinese population,but lower than that in Caucasians.

High-frequency MnZn soft magnetic ferrite by engineering grain boundaries with multiple-ion doping

MnZn soft magnetic ferrites have been widely utilized in power electronics,owing to the combined merits of high permeability and low energy loss.However,their deployment would result in a drastic increase in power dissipation at>3 MHz,thus limiting the scope extent of miniaturization,together with their efficiency.Here,we report a high-performance MnZn ferrite by doping multiple ions(La,Ti,Si,Ca)at grain boundaries,achieving the most optimized power loss of 267 kW/m^(3) at 5 MHz(10 m T,100℃)and initial permeability of 644,which is much better than the previously reported results and commercial products.Such an improvement is attributed to weakened magnetic exchange coupling at grain-boundary regions,associated with a significant transition from the multi-to mono-domain structures,originating physically from large crystallographic mis-orientations(>25°).The present study bears important significance in understanding the intrinsic correlation between the crystallographic mis-orientation and magnetic domain structure,and provides an alternative way for optimizing high-frequency soft magnetic ferrites.

Fenton cleaning strategy for ceramic membrane fouling in wastewater treatment

Membrane fouling is an obstacle impeding the wide applications of ceramic membranes and organics are responsible for most of the membrane fouling issues in wastewater treatment.In this study,Fenton cleaning strategy was firstly proposed to clean ceramic membrane fouling in wastewater treatment.Fe2+ efficiently catalyzed fouling cleaning with H2O2 (1.5%) to recover the filterability of ceramic membrane.The maximum ΔTMP recovery (over 99%) was achieved at an optimal Fe2+ dosage of 124 mg/L after 6 hr of immersion cleaning.The total residual membrane fouling resistance decreased gradually from this optimum value as the Fe2+ dosage increased above 124 mg/L.The residual hydraulically reversible fouling resistance accounted for most of the membrane fouling and was basically removed (≤3.0 × 109 m-1) when Fe2+ dosages higher than 124 mg/L were used.The foulants responsible for the formation of a residual hydraulically reversible fouling layer (DOC (dissolved organic carbon),proteins,polysaccharides,EEM (fluorescence excitationemission matrix spectra),SS (suspended solids),and VSS (volatile suspended solids)) were gradually removed as the Fe2+ dosage increased.These residual organic foulants were degraded from biopolymers (10-200 kDa) to low molecular weight substances (0.1-1 kDa),and the particle size of these residual foulants decreased significantly as a result.The strong oxidation power of hydrogen peroxide/hydroxy radicals towards organic foulants was enhanced by Fe2+.Fe2+ played a significant role in the removal of hydraulically reversible fouling and irreversible fouling from the ceramic membrane.However,Fe2+(≥124 mg/L) increased the likelihood of forming secondary iron-organics aggregates.