Design of Medical Rehabilitation Experience System Based on Extended Reality

This project integrates Extended Reality technology with medical rehabilitation,integrating cloud rendering.interactive experience systems,adaptation platforms,and digital scene resources.It is a innovative application research in the era of metaverset medical rehabilitation.The project uses the Maya engine for the creation of digital assets,with Unity as the main functional development platform and PICO4 as the core device,to achieve interactive and fun experience effects for various rehabilitation training devices.It solves the problems of patients being dull,low participation,lack of confidence in traditional rehabilitation training.as well as the inability of medical staff to monitor patient progress in real time and adjust rehabilitation plans better.

Novel graphene enhancement nanolaser based on hybrid plasmonic waveguides at optical communication wavelength

Surface plasmon polariton （SPP） nanolaser, which can achieve an all-optical circuit, is a major research topic in the field of micro light source. In this study, we examine a novel SPP graphene nanolaser in an optoelectronic integration field. The proposed nanolaser consists of metallic silver, two-dimensional （2D） graphene and high refractive index semiconductor of indium gallium arsenide phosphorus. Compared with other metals, Ag can reduce the threshold and propagation loss. The SPP field, excited by coupling Ag and InGaAsE can be enhanced by the 2D material of graphene. In the proposed nanolaser, the maximum value of propagation loss is approximately 0.055 dB/~tm, and the normalized mode area is con- stantly less than 0.05, and the best threshold can achieve 3380 cm l simultaneously. Meanwhile, the proposed nanolaser can be fabricated by conventional materials and work in optical communication （1550 nm）, which can be easily achieved with current nanotechnology. It is also an important method that will be used to overcome the challenges of high speed, miniaturization, and integration in optoelectronic integrated technology.

Potential Action Mechanism of Baicalin on COVID-19 Based on Network Pharmacology

[Objectives]To collect the main active components and targets of baicalein,and to explore the relationship between their targets and COVID-19 and the treatment mechanism of potential unknown targets.[Methods]The 2D and 3D structures of baicalein(CAS:491-67-8)were obtained by searching Pubchem.The predicted target of baicalein was obtained through the Pharmapper website,and the species specific target was obtained by SEA search server.The COVID-19 related genes were obtained in Genecards and OMIM.The Draw Venny Diagram online program was used to establish the visualized network map of“drug-disease-target”with baicalein monomer target and disease common target and Cytoscape(3.7.2)software.The COVID-19 gene was constructed by using Cytoscape plug-in Bisogenet,and protein-protein interaction(PPI)network was constructed by using the baicalein COVID-19 gene.The CytoNCA topology was used to analyze the network topology and construct the core network.The core network genes were analyzed by GO and KEGG.[Results]Through screening,a total of 358 effective target genes of baicalein,23 common targets of baicalein-COVID-19,and 80 genes of PPI core network were obtained.The total of 1648 GO biological processes including DNA metabolism,positive regulation,intracellular receptor signaling pathway,transforming growth factorβreceptor signaling pathway,regulation of apoptotic signaling pathway,RNA polymerase II transcription factor binding,and 115 KEGG-related signaling pathways involving cell cycle pathways,viral oncogenic pathways,Hepatitis B pathway,Hepatitis C pathway,PI3K-Akt pathway,and ubiquitin-mediated proteolysis,etc.[Conclusions]The effect of baicalein on COVID-19 reflects the characteristics of multiple targets,and it can also regulate the occurrence and development of COVID-19 through various channels.This study is expected to provide a certain basis for subsequent experiments.

4例具有挑战性且不寻常的视网膜病例临床精粹讨论

3位国际视网膜专家在中山眼科中心(Zhongshan Ophthalmic Center,ZOC)眼底病中心进行临床查房并讨论了4例具有挑战性且不寻常的视网膜病例:1)VHL病合并视网膜血管母细胞瘤的11年随访观察;2)半剂量光动力疗法(photodynamic therapy,PDT)或微脉冲激光光凝治疗中心性浆液性视网膜病变(central serous chorioretinopathy,CSC)的观察;3)视神经缺陷儿童的诊断与治疗;4)合并虹膜晶状体脉络膜缺损的视网膜脱离(retinal detachment,RD)的治疗选择。通过讨论有助于我们更好地了解这四例视网膜疾病的发病机制和治疗方法,及其与全身疾病的关系。

Case 02-2017-Discussion of clinical pearls derived from 4 challenging and unusual retinal cases

Four challenging and unusual retinal cases:(I)11-year follow-up for retinal hemangioblastoma with von Hippel-Lindau(VHL)disease;(II)treatment for central serous chorioretinopathy(CSC)-observation,half does photodynamic therapy(PDT)or micropulse laser photocoagulation;(III)diagnosis and treatment for a child with optic nerve defect;(IV)the optional treatment for retinal detachment(RD)with iridolenticular choroidal coloboma,were presented and discussed by three international retinal specialists at a retinal clinical round in Fundus Diseases Center of Zhongshan Ophthalmic Center(ZOC).The discussion helps us a better understanding of the pathogenesis and managements of these four retinal diseases and their association with systemic conditions.

Laser Spot Center Detection and Comparison Test

High efficiency and precision of the pot center detection are the foundations of avionics instrument navigation and optics measurement basis for many applications.It has noticeable impact on overall system performance.Among them,laser spot detection is very important in the optical measurement technology.In order to improve the low accuracy of the spot center position,the algorithm is improved on the basis of the circle fitting.The pretreatment is used by circle fitting,and the improved adaptive denoising filter for TV repair technology can effectively improves the accuracy of the spot center position.At the same time,the pretreatment and de-noising can effectively reduce the influence of Gaussian white noise,which enhances the anti-jamming capability.

A flexible adhesive with a conductivity of 5240 S/cm

Conductive adhesives(CAs)providing reliable connectionsbetween electronic components.have been widely used in solarcells[1],light emitting diodes(LED5)[2],radio frequency compo-nents[3],and printed&wearable circuits.etc.[4-6].Basically,CAs are mainly composed of conductive fillers and resin,whichgive the mechanical.adhesive function.and the conductive path,respectively[7].Among conductive fillers with high conductivity,such as carbon materials[7,8].and metals[4,5.9.10],are the keycomponent[9,10],determining the feature and cost of the CAs.