Mutations in CYBB,encoding gp91^(phox)subunit of NADPH oxidase in phagocytes,impair the respiratory burst of neutrophils and result in X-linked chronic granulomatous disease(CGD).While inflammatory response and NETosi...Mutations in CYBB,encoding gp91^(phox)subunit of NADPH oxidase in phagocytes,impair the respiratory burst of neutrophils and result in X-linked chronic granulomatous disease(CGD).While inflammatory response and NETosis are important modalities employed by neutrophils for pathogen clearance,variants in these cell functions in CGD neutrophils(CGD-PMN)could possibly explain the insufficient defense and accumulation of phagocytes in the sites of infection.展开更多
基金supported by grants from the National Natural Science Foundation of China (No.82173084,82002637).
文摘Mutations in CYBB,encoding gp91^(phox)subunit of NADPH oxidase in phagocytes,impair the respiratory burst of neutrophils and result in X-linked chronic granulomatous disease(CGD).While inflammatory response and NETosis are important modalities employed by neutrophils for pathogen clearance,variants in these cell functions in CGD neutrophils(CGD-PMN)could possibly explain the insufficient defense and accumulation of phagocytes in the sites of infection.
