We propose an integrative self-organizing map (iSOM) for exploring differential expression patterns across multiple microarray experiments. The algorithm is based on the assumption that observed differential expressio...We propose an integrative self-organizing map (iSOM) for exploring differential expression patterns across multiple microarray experiments. The algorithm is based on the assumption that observed differential expressions are random samples of a mean pattern model which is unknowna priori. The learning mechanism of iSOM is similar to the conventional SOM. The mean pattern model which underlies the proposed iSOM models mean differential expressions using a one-dimension of mean differential expressions for the mean differential expressions. The feature map of an iSOM model can be used to reveal correlation between multiple medically/biologically related disease types or multiple platform experiments for one disease. We illustrate applications of iSOM using simulated data and real data.展开更多
Summary What is already known about this topic?Unprotected oral sex carries a risk of the transmission of sexually transmitted infections(STIs),especially if the individual has poor oral health.What is added by this r...Summary What is already known about this topic?Unprotected oral sex carries a risk of the transmission of sexually transmitted infections(STIs),especially if the individual has poor oral health.What is added by this report?Most human immunodeficiency virus(HIV)infected men who have sex with men(MSM)had never used a condom when giving oral sex(89.30%,718/804)or receiving oral sex(90.32%,709/785).Among MSM with detectable viral loads who had ever received oral sex without a condom,40.00%reported ejaculation in their partner’s mouth.展开更多
文摘We propose an integrative self-organizing map (iSOM) for exploring differential expression patterns across multiple microarray experiments. The algorithm is based on the assumption that observed differential expressions are random samples of a mean pattern model which is unknowna priori. The learning mechanism of iSOM is similar to the conventional SOM. The mean pattern model which underlies the proposed iSOM models mean differential expressions using a one-dimension of mean differential expressions for the mean differential expressions. The feature map of an iSOM model can be used to reveal correlation between multiple medically/biologically related disease types or multiple platform experiments for one disease. We illustrate applications of iSOM using simulated data and real data.
基金Supported by the Natural Science Foundation of China Excellent Young Scientists Fund(82022064)Natural Science Foundation of China International/Regional Research Collaboration Project(72061137001)+7 种基金Natural Science Foundation of China Young Scientist Fund(81703278)the National Science and Technology Major Project of China(2018ZX10721102)the Sanming Project of Medicine in Shenzhen(SZSM201811071)the High Level Project of Medicine in Longhua,Shenzhen(HLPM201907020105)the National Key Research and Development Program of China(2020YFC0840900)the Shenzhen Science and Technology Innovation Commission Basic Research Program(JCYJ20190807155409373)Special Support Plan for High-Level Talents of Guangdong Province(2019TQ05Y230)the Fundamental Research Funds for the Central Universities(58000-31620005).
文摘Summary What is already known about this topic?Unprotected oral sex carries a risk of the transmission of sexually transmitted infections(STIs),especially if the individual has poor oral health.What is added by this report?Most human immunodeficiency virus(HIV)infected men who have sex with men(MSM)had never used a condom when giving oral sex(89.30%,718/804)or receiving oral sex(90.32%,709/785).Among MSM with detectable viral loads who had ever received oral sex without a condom,40.00%reported ejaculation in their partner’s mouth.
