Electrochemical mass spectrometry(EC-MS)is a powerful tool to capture and analyze the intermediates and products during elec-trochemical reactions.This hyphenated technique combines electrochemistry with mass spectrom...Electrochemical mass spectrometry(EC-MS)is a powerful tool to capture and analyze the intermediates and products during elec-trochemical reactions.This hyphenated technique combines electrochemistry with mass spectrometry using specific apparatuses,which helps researchers study mechanisms of redox reactions by in situ detecting chemical composition changes.Recently,various EC-MS methods have been applied in a series of electrochemical reactions to reveal the mechanisms,mainly in the areas of electro-chemical sensors,organic electrochemistry,and electrocatalysis.In this review,we intend to summarize the recent advances in re-al-time analysis of different types of electrochemical reactions by EC-MS and offer an outlook on the perspectives in these areas.展开更多
Simplicity and stability of an analytical method are the key to practical applications.In order to achieve such a goal,a molecule with multifunction could be one of the strategies.In this work,the multifunctional char...Simplicity and stability of an analytical method are the key to practical applications.In order to achieve such a goal,a molecule with multifunction could be one of the strategies.In this work,the multifunctional characteristics of branched polyethylenemine(bPEI)were employed for verification of this hypothesis.Three types of amines in the bPEI can be used to synthesize core-shell nanostructures(bPEI@Au and SiO_(2)@bPEI@Au)in a simple one-pot process within 1 h,and as coreactants with over 500-fold enhancement for electrochemiluminescent(ECL)detection.Based on the remarkable performance of bPEI,a label-free ECL immunosensor and its array with the same assembly strategy were constructed for the simple and rapid determination of three acute myocardial infarction(AMI)biomarkers:cardiac troponin I(cTnI),human-type fatty acid binding protein(hFABP)and copeptin.Both methods exhibited excellent stability and sensitivity with wide linear range and low limits of detection down to fg/mL level by the photomultiplier tube and pg/mL level by the electron-multiplying charge-coupled device.展开更多
基金This work was supported by the Beijing National Laboratory for Molecular Sciences(BNLMS-CXXM-202008)the National Science Foundation of China(22034001)the National Key Research and Development Program of China(2016YFA0201300).
文摘Electrochemical mass spectrometry(EC-MS)is a powerful tool to capture and analyze the intermediates and products during elec-trochemical reactions.This hyphenated technique combines electrochemistry with mass spectrometry using specific apparatuses,which helps researchers study mechanisms of redox reactions by in situ detecting chemical composition changes.Recently,various EC-MS methods have been applied in a series of electrochemical reactions to reveal the mechanisms,mainly in the areas of electro-chemical sensors,organic electrochemistry,and electrocatalysis.In this review,we intend to summarize the recent advances in re-al-time analysis of different types of electrochemical reactions by EC-MS and offer an outlook on the perspectives in these areas.
基金supported by the National Key Research and Development Program of China(2016YFA0201300)the National Natural Science Foundation of China(22034001)Beijing National Laboratory for Molecular Sciences(BNLMS-CXXM-202008)。
文摘Simplicity and stability of an analytical method are the key to practical applications.In order to achieve such a goal,a molecule with multifunction could be one of the strategies.In this work,the multifunctional characteristics of branched polyethylenemine(bPEI)were employed for verification of this hypothesis.Three types of amines in the bPEI can be used to synthesize core-shell nanostructures(bPEI@Au and SiO_(2)@bPEI@Au)in a simple one-pot process within 1 h,and as coreactants with over 500-fold enhancement for electrochemiluminescent(ECL)detection.Based on the remarkable performance of bPEI,a label-free ECL immunosensor and its array with the same assembly strategy were constructed for the simple and rapid determination of three acute myocardial infarction(AMI)biomarkers:cardiac troponin I(cTnI),human-type fatty acid binding protein(hFABP)and copeptin.Both methods exhibited excellent stability and sensitivity with wide linear range and low limits of detection down to fg/mL level by the photomultiplier tube and pg/mL level by the electron-multiplying charge-coupled device.
