Importance:In children,anesthesia dosages are based on population pharmacokinetics and patient hemodynamics rather than patient-specific brain activity.Brain function is highly susceptible to the effects of anesthetic...Importance:In children,anesthesia dosages are based on population pharmacokinetics and patient hemodynamics rather than patient-specific brain activity.Brain function is highly susceptible to the effects of anesthetics.Objective:The primary objective of this retrospective pilot study was to assess the prevalence of electroencephalography(EEG)burst suppression-a sign of deep anesthesia-in children undergoing general anesthesia.Methods:We analyzed EEG in patients aged 1-36 months who received sevoflurane or propofol as the primary anesthetic.Patient enrollment was stratified into two age groups:1-12 months and 13-36 months.Burst suppression(voltage≤5.0 mV,lasting>0.5 seconds)was characterized by occurrence over anesthesia time.Associations with patient demographics and anesthetics were determined.Results:In total,54 patients(33 males and 21 females)were included in the study[age 11.0(5.0-19.5)months;weight 9.2(6.5-11.0)kg].The total prevalence of burst suppression was 56%(30/54).Thirty-three percent of patients experienced burst suppression during the surgical phase.The greatest proportion of burst suppression occurred during the induction phase.More burst suppression event occurrences(18/30)were observed in the patient under sevoflurane anesthesia(P=0.024).Virtually all patients who received propofol boluses had burst suppression(P=0.033).More burst suppression occurred in patients with hypotension(P<0.001).During the surgical phase,a younger age was associated with more burst suppression(P=0.002).Interpretation:EEG burst suppression was associated with younger age,inhalation anesthetics,propofol bolus,and lower arterial pressure.展开更多
文摘Importance:In children,anesthesia dosages are based on population pharmacokinetics and patient hemodynamics rather than patient-specific brain activity.Brain function is highly susceptible to the effects of anesthetics.Objective:The primary objective of this retrospective pilot study was to assess the prevalence of electroencephalography(EEG)burst suppression-a sign of deep anesthesia-in children undergoing general anesthesia.Methods:We analyzed EEG in patients aged 1-36 months who received sevoflurane or propofol as the primary anesthetic.Patient enrollment was stratified into two age groups:1-12 months and 13-36 months.Burst suppression(voltage≤5.0 mV,lasting>0.5 seconds)was characterized by occurrence over anesthesia time.Associations with patient demographics and anesthetics were determined.Results:In total,54 patients(33 males and 21 females)were included in the study[age 11.0(5.0-19.5)months;weight 9.2(6.5-11.0)kg].The total prevalence of burst suppression was 56%(30/54).Thirty-three percent of patients experienced burst suppression during the surgical phase.The greatest proportion of burst suppression occurred during the induction phase.More burst suppression event occurrences(18/30)were observed in the patient under sevoflurane anesthesia(P=0.024).Virtually all patients who received propofol boluses had burst suppression(P=0.033).More burst suppression occurred in patients with hypotension(P<0.001).During the surgical phase,a younger age was associated with more burst suppression(P=0.002).Interpretation:EEG burst suppression was associated with younger age,inhalation anesthetics,propofol bolus,and lower arterial pressure.
