Gastric cancer(GC)ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide.Reactive oxygen species(ROS)are highly oxidative oxygen-derived products that have crucial roles in cell signaling reg...Gastric cancer(GC)ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide.Reactive oxygen species(ROS)are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal balance.ROS are closely associated with the occurrence,development,and treatment of GC.This review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS induction.In addition,the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is summarized.The aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.展开更多
基金This study was supported by The National Key Research and Development Program of China(Grant No.2021YFA0910100)Healthy Zhejiang One Million People Cohort(Grant No.K-20230085)+11 种基金Post-doctoral Innovative Talent Support Program(Grant No.BX2023375)Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer(Grant No.JBZX-202006)Medical Science and Technology Project of Zhejiang Province(Grant No.WKJ-ZJ-2202 and WKJ-ZJ-2104)National Natural Science Foundation of China(Grant Nos.823049468207424581973634and 81903842)Natural Science Foundation of Zhejiang Province(Grant No.LR21H280001)Science and Technology Projects of Zhejiang Province(Grant No.2019C03049)Program of Zhejiang Provincial TCM Scitech Plan(Grant Nos.2018ZY0062020ZZ005)China Postdoctoral Science Foundation(Grant No.2023M733563).
文摘Gastric cancer(GC)ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide.Reactive oxygen species(ROS)are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal balance.ROS are closely associated with the occurrence,development,and treatment of GC.This review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS induction.In addition,the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is summarized.The aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.
